#tbsky — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tbsky, aggregated by home.social.
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"As longevity increases in Southern Africa, healthy-ageing interventions for tuberculosis survivors could improve function and survival into older age." #TBSky #IDSky by @[email protected] & team academic.oup.com/jid/advance-...
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"In this proof-of-concept study, 4 months of delamanid, bedaquiline, and quabodepistat showed a promising end-of-treatment non-inferiority signal versus 6 months of RHEZ and was generally well tolerated." @[email protected] #IDSky #TBSky www.thelancet.com/journals/lan...
Efficacy and safety of a 4-mon... -
Without fail, lack of time drifts me away from this platform, then I return and spot lots of good work content, and then rue not being here more and wonder what I've missed! 🤦♂️🤷♂️ #IDSky #ClinMicro #UTISky #TBSky #AcademicSky
Danny McNamara Says Everytime -
Nice demonstration by @[email protected] et al that some, but not all, non tuberculous mycobacteria (NTM) intracellular growth in macrophages is pH sensitive #TBSky #immunosky onlinelibrary.wiley.com/doi/10.1111/...
Acidic pH Restricts Non‐Tuberc... -
Agree re potentially practice changing. Will be interesting to see if/when its performance gets tested in identifying asymptomatic (but probably infectious) TB cases. Could have even bigger impact on transmission and lowering case numbers. #IDSky #TBSky
RE: https://bsky.app/profile/did:plc:skpxj6dpacrxznfvwrpfdiw4/post/3mkqrvxs26c2w -
i should add, finding it was triggered by this very good commentary (with a good title) #TBSky #IDSky www.nature.com/articles/s41...
The ghost of tuberculosis past... -
I think i'd missed this. Generates many hypotheses (in my head anyway) on the biological pathways that may be underlying this increased risk of death for many years after TB diagnosis & treatmnent. #IDSky #TBSky www.nature.com/articles/s41...
Long-term risk of death after ... -
Great progress on vaccines & host-directed therapies (HDT) in TB. Our review on IL-17👇 🎯protective early on & post-vaccine in animal models 👉desirable for vaccines? 🎯Drive pathology in TB disease👉target for HDT to limit post-TB lung damage? With @[email protected] @[email protected] #TBSky #ImmunoSky
Context-specific roles for IL-... -
Great progress on vaccines & host-directed therapies (HDT) in TB. Our review on IL-17👇 🎯protective early on & post-vaccine in animal models 👉desirable for vaccines? 🎯Drive pathology in TB disease👉target for HDT to limit post-TB lung damage? With @[email protected] @[email protected] #TBSky #ImmunoSky
Context-specific roles for IL-... -
Great progress on vaccines & host-directed therapies (HDT) in TB. Our review on IL-17👇 🎯protective early on & post-vaccine in animal models 👉desirable for vaccines? 🎯Drive pathology in TB disease👉target for HDT to limit post-TB lung damage? With @[email protected] @[email protected] #TBSky #ImmunoSky
Context-specific roles for IL-... -
Great progress on vaccines & host-directed therapies (HDT) in TB. Our review on IL-17👇 🎯protective early on & post-vaccine in animal models 👉desirable for vaccines? 🎯Drive pathology in TB disease👉target for HDT to limit post-TB lung damage? With @[email protected] @[email protected] #TBSky #ImmunoSky
Context-specific roles for IL-... -
Of note, TB helps here - turnaround time not THAT fast (still 16 days from positive culture to WGS guided treatment recommendations), but it's a slow disease. Not easily applicable to all other infections #TBSky #IDSky #ESCMIDGlobal2026 (2/3)
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Quite impressive to see a new diagnostic intervention (whole genome sequencing for rifampicin-resistant TB) to be superior to SOC. Giving better drugs quicker works! Though note this was vs old standard of care for MDR-TB. (ie SOC now likely would do better anyway) #ESCMIDGlobal2026 #TBSky (1/3)
RE: https://bsky.app/profile/did:plc:4xb2h7na3qzshqu2yxtiylwj/post/3mjwgmuchfc24 -
And an excellent summary. It's all go in the world of TB treatment! #ESCMIDGlobal2026 #TBSky #IDSky
RE: https://bsky.app/profile/did:plc:dmy36y7p2lwmdc54fjis4uez/post/3mjrsbtiov22v -
Nice vision by Nicholas Paton for TB treatment in the future. 8 week oral treatment followed by long-acting injectable that could be antimicrobial +/- host-directed. Definitely a post to come back to in 5-10 years' time! #ESCMIDGlobal2026 #IDSky #TBSky
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Recent nice paper @[email protected] looked at this: radiolgical changes (not culture) in asymptomatic contacts predictive of risk of TB disease development. PET-CT best but CXR not bad and feasible. @[email protected] www.thelancet.com/journals/lan... #IDSky #TBSky #ESCMIDGlobal2026 (2/2)
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Excellent talk from Hanif Esmail on asymptomatic TB. Around half of M tuberculosis culture positive patients have no symptoms & probably contributes to transmission. Who should we offer treatment to? #TBSky #IDSky #ESCMIDGlobal2026 (1/2)
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Revisiting tuberculosis diagnostics: progress, pitfalls, and future directions #IDSky #TBSky @[email protected] www.clinicalmicrobiologyandinfection.org/article/S119...
Revisiting tuberculosis diagno... -
Played a small part in this cool study @[email protected]. Identifies myofibroblasts as sources of tissue damaging enzymes (MMP1) in TB granuloma, probably responding to cytokine cues from nearby macrophages. Question now is: can we target therapeutically to prevent post-TB lung damage? #TBSky #IDSky
Single-cell and spatial profil... -
Unsurprising yet still depressing #TBSky #IDSky
RE: https://bsky.app/profile/did:plc:ijpuo3dixtusb2p3vmqfkjkg/post/3mflxwwwauc2z -
Quite clever how you can detect Mycobacterial antigens in extracellular vehicles in blood during asymptomatic TB. Useful as biomarkers but maybe also to work out in vivo what are early / most abundant Mtb antigens produced. #TBSky academic.oup.com/jid/advance-...
Optimized Mass Spectrometry to... -
Mycobacterium tuberculosis is so evolved at surviving environmental stresses! By @[email protected] & team #TBSky #MicroSky @[email protected] link.springer.com/article/10.1...
Membrane-associated effluxosom... -
TB transmission in healthcare is thankfully rare. Good to get some metrics of what are the highest risk exposures (that are worth following up). #IDSky #TBSky @[email protected] academic.oup.com/cid/advance-...
Mycobacterium tuberculosis Tra... -
This is a very appealing meeting in Paris later this year... "The complexity of mycobacterial infections: from research to real-world impact" #EMBOComplexInfections #TBSky for the tuberculosis research, but also #NTM #Leprosy #IDSky #ImmunoSky meetings.embo.org/event/26-myc...
The complexity of mycobacteria... -
If interested in meta-analysis of TB patient data from trials, do get in touch with colleagues at UCL below! 👇 #IDSky #MedSky #TBSky
RE: https://bsky.app/profile/did:plc:cvxu4bmctgte2kxb6awtem2z/post/3mbh2pl26b22a -
This is a noble idea for the #TBSky research community. TBH could aim for this in any research field - studies often collect and bank far more material than is used. Question though is: how do you police access, MTAs, contracts, IP etc.. 🤯 #IDSky #MedSky #AcademicSky @[email protected]
The need for interconnected gl... -
Post-TB lung disease - the impact of TB on patients does not end with the course of antibiotics, characterised by substantial long-term pulmonary impairment. Proposed case definition to support assessments and interventions in research studies 👇 #TBSky #IDSky @[email protected]
Post-tuberculosis lung disease... -
Ok, I've learned something new - acid fast stains bind nucleic acids and not mycolic acid on mycobacterial cell wall. The lipid-rich cell wall simply prevents acid-alcohol decolourisation, hence acid -fast. #TBSky #IDSky @lancetmicrobe.bsky.social www.thelancet.com/journals/lan...
Fluorescent acid-fast stains f... -
Interesting different levels of virulence comparing organisms across a broad range of the Mycobacterium tuberculosis complex (MTBC). @pnas.org @mbehr-mcgill.bsky.social #TBSky www.pnas.org/doi/10.1073/...
Virulence hierarchies within t... -
Interesting idea / biology potentially but this feels unlikely to be highly discriminatory and thus converted to a useful diagnostic! #IDSky #TBSky #MedSky
Distinguishing tuberculosis fr... -
Great job @sarasuliman.bsky.social on discussing the evolution of Mycobacterium tuberculosis in human populations over time #TBSky #IDSky #MedSky 🧪 #genetics www.nature.com/articles/s41...
The evolution of Mycobacterium... -
Great job @sarasuliman.bsky.social on discussing the evolution of Mycobacterium tuberculosis in human populations over time #TBSky #IDSky #MedSky 🧪 #genetics www.nature.com/articles/s41...
The evolution of Mycobacterium... -
Great job @sarasuliman.bsky.social on discussing the evolution of Mycobacterium tuberculosis in human populations over time #TBSky #IDSky #MedSky 🧪 #genetics www.nature.com/articles/s41...
The evolution of Mycobacterium... -
Host-directed therapies for infectious disease are here & coming! Simple equation proposed to consider best interventions: ⭐ Microorganism + immune response = clinical presentation/status ⭐ Will require futuristic-sounding real-time diagnostics = exciting! #IDSky #MedSky #ImmunoSky #TBSky
The Changing Paradigm in Infec... -
There you go - TB shaping the immune system (MHC class II) of meerkats! #TBSky #ImmunoSky 🧪 www.nature.com/articles/s41...
Twenty years of tuberculosis-d... -
This is quite cool! "the AveloMask Kit, a user-friendly, non-invasive face mask that captures exhaled aerosols and transfers them into a buffer tube for molecular detection of respiratory tract infections" #IDSky #ClinMicro #TBSky journals.asm.org/doi/10.1128/...
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Another immune mechanism in TB in which a seemingly host protective response (immunothrombosis) may get out of hand and drive tissue pathology. @jidjournal.bsky.social #IDSky #TBSky #ImmunoSky 🧪
The emerging role of immunothr... -
As paper titles involving TB go, this one using the rhyming Fc is not bad... (also a good synopsis of an important paper) #IDSky #TBSky #immunosky www.science.org/doi/10.1126/...
TB or not TB: That depends on ... -
V interesting step forward in discovering generalisable / public human T cell metaclones reactive to Mycobacterium tuberculosis antigens in vivo. Potential impact for: 👉 Risk stratification 👉 Vaccine design Do read more details in preprint 👇 #IDSky #TBSky #tuberculosis #immunosky
RE: https://bsky.app/profile/did:plc:jbailtwiei4sp5o4a2efvo2z/post/3lndotheskv22 -
V interesting step forward in discovering generalisable / public human T cell metaclones reactive to Mycobacterium tuberculosis antigens in vivo. Potential impact for: 👉 Risk stratification 👉 Vaccine design Do read more details in preprint 👇 #IDSky #TBSky #tuberculosis #immunosky
RE: https://bsky.app/profile/did:plc:jbailtwiei4sp5o4a2efvo2z/post/3lndotheskv22 -
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)
Altered IL-6 signalling and ri... -
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)
Altered IL-6 signalling and ri... -
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)
Altered IL-6 signalling and ri... -
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)
Altered IL-6 signalling and ri... -
And just in time for #UnionConf2024 delighted to be joined here by colleagues @ucltb.bsky.social. Do give them a follow for all the cool TB work coming out of our university! #IDSky #TBSky #tuberculosis
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And just in time for #UnionConf2024 delighted to be joined here by colleagues @ucltb.bsky.social. Do give them a follow for all the cool TB work coming out of our university! #IDSky #TBSky #tuberculosis