#clinmicro — Public Fediverse posts

The fine balance of prophylactic antibiotics. Prevent infections but are these infections significant and at what cost (resistance)? Here in stem cell transplants, but also relevant to other settings #IDSky #UTISky #AMR #ClinMicro academic.oup.com/ofid/advance...

Effect of quinolone prophylaxi...

Without fail, lack of time drifts me away from this platform, then I return and spot lots of good work content, and then rue not being here more and wonder what I've missed! 🤦‍♂️🤷‍♂️ #IDSky #ClinMicro #UTISky #TBSky #AcademicSky

Danny McNamara Says Everytime

So good. Have spent years fighting this fight, with hand tied behind my back by lack of great evidence. This study is going to get quoted and cited in microbiology MDTs the world over +++ #IDSky #ClinMicro #AMR

RE: https://bsky.app/profile/did:plc:klwvdtksagcziyylwqukjgal/post/3mlsq453bqk2e

Interesting description of heteroresistance to piptaz, but from a highly monitored patient in a clinical trial. And was not associated with treatment failure Most patients don't have post-antibiotic microbiology samples, so maybe this happens commonly (& inconsequentially) #IDSky #ClinMicro #UTISky

RE: https://bsky.app/profile/did:plc:l7hoy6b4k4tuwysko34jriwi/post/3mko2f3cdxc2i

Impressive - @[email protected] now has 10,000 members worldwide! #ClinMicro #AMR #IDSky @[email protected]

Important piece of work that guides much of our OPAT practice in UK. It's also impressive in its acceptance of the evidence. Literally the guideline for use of IV antibiotics is advocating for use of oral antibiotics instead! 👏 #IDSky #ClinMicro #AMR #OPAT

RE: https://bsky.app/profile/did:plc:l7hoy6b4k4tuwysko34jriwi/post/3mk62wkqymc27

A sobering but very important observation about war and antibiotic resistance #IDSky #ClinMicro #AMR

RE: https://bsky.app/profile/did:plc:l7hoy6b4k4tuwysko34jriwi/post/3mjyl3hct3k26

For those that don't know (included me!), Gremubamab binds specifically to the Pseudomonas aeruginosa PcrV protein and the Psl exopolysaccharide. Both are virulence factors used for adhesion and biofilm stability. Thanks @[email protected] ! #ESCMIDGlobal2026 #IDSky #ClinMicro

RE: https://bsky.app/profile/did:plc:jh6ykfvllrvxnubjpzazm2vb/post/3mjr55jvdxc2u

"Among 5121 participants assessed, 1573 (30.7%) underwent DOC, of which 1502 (95.5%) were delabeled." - that's a lot of penicillin allergy mislabelling out there! 😲 However... DOC.. more likely to be prescribed penicillin and less likely WHO “Watch” or “Reserve” antibiotics #IDSky #ClinMicro #AMR

Direct Oral Challenge for Peni...

Some real works of art here!!! #MicroSky #ClinMicro

RE: https://bsky.app/profile/did:plc:bzoexbcy5cvljh2npflko4ow/post/3mi3dbu3auc2z

We do quite a lot of antibiotic self administration in OPAT. Massive win if it can be achieved - lower requirements on hospital / community nurses & big autonomy win for the patients and their families. #OPAT #IDSky #ClinMicro

RE: https://bsky.app/profile/did:plc:ihlofya6s7dijxbv242tjam6/post/3mhq73irnj22b

The Widal test drives typhoid over diagnosis and, by extension, unnecessary antibiotic prescriptions. Good piece in @[email protected] #IDSky #ClinMicro #AMR

The diagnostic void: how typho...

Well, that was effective use of social media time! Had totally forgotten about this webinar next Monday! Look forward to hearing from @[email protected] & @[email protected] #IDSky #ClinMicro #UTISky @[email protected]

RE: https://bsky.app/profile/did:plc:iuu7h4phnqvxwkiv36wbu4ll/post/3mgakcgctmc2w

Important letter in @[email protected] on use of cefalexin in treating pyelonephritis. Is it effective? What's the right dose? 🤷‍♂️ Key quote... 👉 "Critically, there are no EUCAST breakpoints for cefalexin for systemic infection including acute pyelonephritis." #IDSky #ClinMicro #AMR #UTISky

Cefalexin use in UK acute pyel...

Plasma cell free metagenomic sequencing to predict / diagnose blood stream infections. Neat & promising observational data. Even if unsurprising, remarkable to see increased detection of microbial genomic material as diagnosis nears. @[email protected] #IDSky #ClinMicro #UTISky #MedSky

Predicting bloodstream infecti...

I was enjoying this bit of trivia about the origins of name sakazakii, but then the backstory on Cronos was .... 😲 #IDSky #ClinMicro

RE: https://bsky.app/profile/did:plc:ao7ykaoap23gbmrggv4ytobn/post/3mfqscw2c7v2r

Unexpected Friday bonus - new paper out (NOT peer reviewed)! Standardised antibiotic spectrum scores to: - quantify impact of antimicrobial stewardship rounds - prioritise patients for stewardship review Co-lead @[email protected] #IDSky #AMS #ClinMicro wellcomeopenresearch.org/articles/11-...

Cheery and scary title popped into my inbox. Not even disinfectants working?! 😨 "Molecular mechanisms of disinfectant resistance in Klebsiella pneumoniae" #ClinMicro #IDSky @[email protected] #MedSky #IPC academic.oup.com/jacamr/artic...

Molecular mechanisms of disinf...

Microbiology in space aboard the International Space Station!!! Surely astronauts contributed enough to get authorship?! #science #MicroSky #ClinMicro #phages #UTISky

RE: https://bsky.app/profile/did:plc:5522ztebtekoor5efelihqhb/post/3mcfm5qyhep2c

Gepotidacin provides #UTI symptomatic relief comparably to nitrofurantoin (in people with uncomplicated UTI in trials) #UTISky #IDSky #ClinMicro #MedSky @[email protected] academic.oup.com/cid/advance-...

Early symptom response in pati...

The kind of question to keep Infection doctors up at night! #IDSky #AMR #ClinMicro #MedSky

RE: https://bsky.app/profile/did:plc:krpxejciqiuk7vqttm5s7doq/post/3mbnfgjettc25

This is an interesting scheme - making compelling journal submissions is hard, and early rejections are often met with little to no feedback. Nice to see a journal offering to make this a learning process for early career researchers. @[email protected] #IDSky #MedSky #ClinMicro #AcademicSky

RE: https://bsky.app/profile/did:plc:6peijvvlgjki2rrxitoa65sv/post/3mbi3mp6cvi2v

Other than jumbling up what acronyms like OPAT and COPATusually stand for in my world, this was a good study with a clear, if expected, message on safety benefit of oral antibiotics. #IDSky #ClinMicro #medsky

RE: https://bsky.app/profile/did:plc:xm2upaaxj6vztbiu2tom75aq/post/3malgvkvxd22v

I like this v much. Learning from radiation safety to minimise harm (personal & societal) of antibiotics #IDSky #MedSky #ClinMicro #AMR "ALARA in Antimicrobial Stewardship: Adapting Radiation Safety Principles to Address Antibiotic Overuse" @[email protected] academic.oup.com/cid/advance-...

Errr... What?! Am I?! #IDSky #ClinMicro #AMR #WAAW Great doodles @[email protected] 👏

RE: https://bsky.app/profile/did:plc:gpmq5w5m7wx4cpph3yqsdhge/post/3m5wufjcpdk2g

Still trying to get my head round what this model is predicting, as usually at least some clinical information is provided with microbiology samples. #AI #IDSky #ClinMicro #UTISky #AMR @[email protected] academic.oup.com/jac/advance-...

Machine learning for personali...

Can't say I've even ever heard of cefdinir, probably cos we can't get it. But maybe we don't want it anyway! 😉 👇 #IDSky #ClinMicro #UTISky

RE: https://bsky.app/profile/did:plc:hczgnomn6gxwalzjrskgl4hc/post/3m3vl2y7n5c2y

Clever use of two Greek mythological metaphors to talk about cefiderocol mechanism of action and resistance. #IDSky #ClinMicro #AMR academic.oup.com/jac/advance-...

The Achilles’ heel of the Troj...

Love this. 😍 BLING randomised trials showed benefit of continuous antibiotic infusion, and there you go, change in practice is delivered! 👏 @ics-updates.bsky.social @biainfection.bsky.social #IDSky #ClinMicro #sepsis

RE: https://bsky.app/profile/did:plc:x34ddhklxbv74q5ac2aub77f/post/3m3rfqngea22j

At first seems like comparing apples and oranges: moxifloxacin vs vancomycin?! Results a bit surprising ("narrow spectrum" vancomycin change microbiome more), but this is just helicopter view. More broadly, 👏 to these experimental medicine approaches for discovery science #IDSky #ClinMicro #AMR

A randomized phase 1 study inv...