#escmidglobal2026 — Public Fediverse posts

Of note, TB helps here - turnaround time not THAT fast (still 16 days from positive culture to WGS guided treatment recommendations), but it's a slow disease. Not easily applicable to all other infections #TBSky #IDSky #ESCMIDGlobal2026 (2/3)

Quite impressive to see a new diagnostic intervention (whole genome sequencing for rifampicin-resistant TB) to be superior to SOC. Giving better drugs quicker works! Though note this was vs old standard of care for MDR-TB. (ie SOC now likely would do better anyway) #ESCMIDGlobal2026 #TBSky (1/3)

RE: https://bsky.app/profile/did:plc:4xb2h7na3qzshqu2yxtiylwj/post/3mjwgmuchfc24

SCOUT UTI study great. N=768 👍. Interesting observations: 👉 clearly nitro great 👉 pivm also great (held back vs ESBL, but not inferior) 👉 fosfo not great *even with 2 doses*. Were these the non-E coli? 👉 better clinical resolution if micro +ve. Some are not actually UTI? #ESCMIDGlobal2026 #UTISky

RE: https://bsky.app/profile/did:plc:4xb2h7na3qzshqu2yxtiylwj/post/3mjwfev2sxk24

There is definitely a sweet spot of playback speed. Go too fast you have to keep going back (with low accuracy) to catch bits you've missed and then you take even longer overall to watch the video! (and then spend more time posting here about the experience! 🤦) #ESCMIDGlobal2026

RE: https://bsky.app/profile/did:plc:dmy36y7p2lwmdc54fjis4uez/post/3mjubkj4wos2z

Bit perplexed by this dalbavancin PK-PD data from DOTS study. Modest association higher dalbavancin exposure & better outcome in Staph aureus bacteraemia. Hard to know if giving more drug (3rd dose) would increase exposure when it matters (early?). Host drug metabolism factors? #ESCMIDGlobal2026

Due to work commitments yesterday, today is my #ESCMIDGlobal2026 catch up day. Question is... Do I live post talks I watch in replay?! I'm assuming crowd are screaming "please no" 📢 so maybe this opens up space for slower summary posts 🤔 Maybe this is the way to make some useful CPD notes! 😉 👇

RE: https://bsky.app/profile/did:plc:dmy36y7p2lwmdc54fjis4uez/post/3mjubkj4wos2z

UTI field on 🔥 - so much happening - case (re-)definitions, diagnosis & treatment #UTISky #ESCMIDGlobal2026

New(ish) diagnostics in UTI diagnosis Rapid culture in nano format - results in <1hr Promising for fast turnaround results - impact on clinical care? #UTIsky #ESCMIDGlobal2026

Interesting idea from @[email protected] data - using urine metabolomics (from bacteria) to predict risk of UTI recurrence. Needs validation and even if it validates, interesting to think what one could do with that information! #ESCMIDGlobal2026 #UTISky

The answer to previous question.... Check out Lactobacillus in healthy but also that oestrogen replacement makes rUTI group look like healthy. Question is whether the increased Lactobacillus are the mechanims through UTI prevention with oestrogen @[email protected] #UTISky #ESCMIDGlobal2026

RE: https://bsky.app/profile/did:plc:dmy36y7p2lwmdc54fjis4uez/post/3mjucjgme6k2z

Differences in the urinary microbiome at the time of UTI (not surprising) and when not having an active infection. But what's different in the rUTI remission group vs healthy? (next slide...) @[email protected] #ESCMIDGlobal2026

RE: https://bsky.app/profile/did:plc:dmy36y7p2lwmdc54fjis4uez/post/3mjuc2xm5zc2z

Normal urine is not sterile! Urine microbiome being introduced by @[email protected] #ESCMIDGlobal2026 #UTISky

Warning to all those remote attending and looking to accrue CME points via #ESCMIDGlobal2026. You can't claim to be able to take in information twice as fast as in person attendees!!! 🤣

A post applicable way beyond just #ESCMIDGlobal2026! 👇 #MedSky #AcademicSky

RE: https://bsky.app/profile/did:plc:vcmyw2jthzh5tcbviee25zda/post/3mjsi3jblks2d

And an excellent summary. It's all go in the world of TB treatment! #ESCMIDGlobal2026 #TBSky #IDSky

RE: https://bsky.app/profile/did:plc:dmy36y7p2lwmdc54fjis4uez/post/3mjrsbtiov22v

Nice vision by Nicholas Paton for TB treatment in the future. 8 week oral treatment followed by long-acting injectable that could be antimicrobial +/- host-directed. Definitely a post to come back to in 5-10 years' time! #ESCMIDGlobal2026 #IDSky #TBSky

Recent nice paper @[email protected] looked at this: radiolgical changes (not culture) in asymptomatic contacts predictive of risk of TB disease development. PET-CT best but CXR not bad and feasible. @[email protected] www.thelancet.com/journals/lan... #IDSky #TBSky #ESCMIDGlobal2026 (2/2)

Excellent talk from Hanif Esmail on asymptomatic TB. Around half of M tuberculosis culture positive patients have no symptoms & probably contributes to transmission. Who should we offer treatment to? #TBSky #IDSky #ESCMIDGlobal2026 (1/2)

For those that don't know (included me!), Gremubamab binds specifically to the Pseudomonas aeruginosa PcrV protein and the Psl exopolysaccharide. Both are virulence factors used for adhesion and biofilm stability. Thanks @[email protected] ! #ESCMIDGlobal2026 #IDSky #ClinMicro

RE: https://bsky.app/profile/did:plc:jh6ykfvllrvxnubjpzazm2vb/post/3mjr55jvdxc2u

Finally, biggest question of all - do we want an oral carbapenem out in the wild? (especially once it then eventually goes generic and cheap!) #ESCMIDGlobal2026

a man standing in front of a w...

Tebipenem (oral carbapenem) hasn't gone away. Subgroup analyses from PIVOT-PO study suggests non-inferiority of tebipenem. Plots below are clinical response. Interest to note: - post-treatmemt bacteriuria rates higher in tebipenem - still general lean away from tebipenem (1/3) #ESCMIDGlobal2026

Difficult to know what to say about tebipenem for pyelonephritis. Small sample sizes but tebipenem looks worrying for use in pyelonephritis with bacteraemia - problem is you never know who does / does not have bacteraemia (and we probably miss many) #ESCMIDGlobal2026

Definitely one thing I'm not sad to be missing by not being in person at #ESCMIDGlobal2026!! (human meetings I do wish I was there for)

RE: https://bsky.app/profile/did:plc:vt7cbqjs4l4jcic6opl7jpmy/post/3mjqzt2gcgf2t

Liking this style of summary video from #ESCMIDGlobal2026 by @[email protected] Hopefully more to come...

RE: https://bsky.app/profile/did:plc:vcmyw2jthzh5tcbviee25zda/post/3mjovpire5k2v

This could actually be quite handy for following the massive programme at #ESCMIDGlobal2026 Instructions are a bit technical, and availability is not yet universal amongst LLMs, so this year it may not be ready for mass adoption. However this could become a v useful bit of #AI at large conferences!

RE: https://bsky.app/profile/did:plc:vt7cbqjs4l4jcic6opl7jpmy/post/3mjmpt3svl62u

Getting serious FOMO with both @[email protected] #microbio26 and @[email protected] #ESCMIDGlobal2026 happening this week! Hope everyone at both conferences has a great time and can't wait to hear about the great science being reported!