#utisky — Public Fediverse posts

Interesting description of heteroresistance to piptaz, but from a highly monitored patient in a clinical trial. And was not associated with treatment failure Most patients don't have post-antibiotic microbiology samples, so maybe this happens commonly (& inconsequentially) #IDSky #ClinMicro #UTISky

RE: https://bsky.app/profile/did:plc:l7hoy6b4k4tuwysko34jriwi/post/3mko2f3cdxc2i

Interesting data, including how presence of the stents alters the pathogens identifed. #UTISky

RE: https://bsky.app/profile/did:plc:l7hoy6b4k4tuwysko34jriwi/post/3mjyyrupoj22n

SCOUT UTI study great. N=768 👍. Interesting observations: 👉 clearly nitro great 👉 pivm also great (held back vs ESBL, but not inferior) 👉 fosfo not great *even with 2 doses*. Were these the non-E coli? 👉 better clinical resolution if micro +ve. Some are not actually UTI? #ESCMIDGlobal2026 #UTISky

RE: https://bsky.app/profile/did:plc:4xb2h7na3qzshqu2yxtiylwj/post/3mjwfev2sxk24

UTI field on 🔥 - so much happening - case (re-)definitions, diagnosis & treatment #UTISky #ESCMIDGlobal2026

New(ish) diagnostics in UTI diagnosis Rapid culture in nano format - results in <1hr Promising for fast turnaround results - impact on clinical care? #UTIsky #ESCMIDGlobal2026

Interesting idea from @[email protected] data - using urine metabolomics (from bacteria) to predict risk of UTI recurrence. Needs validation and even if it validates, interesting to think what one could do with that information! #ESCMIDGlobal2026 #UTISky

The answer to previous question.... Check out Lactobacillus in healthy but also that oestrogen replacement makes rUTI group look like healthy. Question is whether the increased Lactobacillus are the mechanims through UTI prevention with oestrogen @[email protected] #UTISky #ESCMIDGlobal2026

RE: https://bsky.app/profile/did:plc:dmy36y7p2lwmdc54fjis4uez/post/3mjucjgme6k2z

Normal urine is not sterile! Urine microbiome being introduced by @[email protected] #ESCMIDGlobal2026 #UTISky

Normal urine is not sterile! Urine microbiome being introduced by @[email protected] #ESCMIDGlobal2026 #UTISky

Normal urine is not sterile! Urine microbiome being introduced by @[email protected] #ESCMIDGlobal2026 #UTISky

Well, that was effective use of social media time! Had totally forgotten about this webinar next Monday! Look forward to hearing from @[email protected] & @[email protected] #IDSky #ClinMicro #UTISky @[email protected]

RE: https://bsky.app/profile/did:plc:iuu7h4phnqvxwkiv36wbu4ll/post/3mgakcgctmc2w

Important letter in @[email protected] on use of cefalexin in treating pyelonephritis. Is it effective? What's the right dose? 🤷‍♂️ Key quote... 👉 "Critically, there are no EUCAST breakpoints for cefalexin for systemic infection including acute pyelonephritis." #IDSky #ClinMicro #AMR #UTISky

Cefalexin use in UK acute pyel...

Plasma cell free metagenomic sequencing to predict / diagnose blood stream infections. Neat & promising observational data. Even if unsurprising, remarkable to see increased detection of microbial genomic material as diagnosis nears. @[email protected] #IDSky #ClinMicro #UTISky #MedSky

Predicting bloodstream infecti...

Good overview of an increasingly rapid-evolving field, including newly updated guidelines, non-antibiotic treatments and focus on quality of life. #UTISky academic.oup.com/cid/advance-...

Uncomplicated Urinary Tract In...

Microbiology in space aboard the International Space Station!!! Surely astronauts contributed enough to get authorship?! #science #MicroSky #ClinMicro #phages #UTISky

RE: https://bsky.app/profile/did:plc:5522ztebtekoor5efelihqhb/post/3mcfm5qyhep2c

Microbiology in space aboard the International Space Station!!! Surely astronauts contributed enough to get authorship?! #science #MicroSky #ClinMicro #phages #UTISky

RE: https://bsky.app/profile/did:plc:5522ztebtekoor5efelihqhb/post/3mcfm5qyhep2c

Microbiology in space aboard the International Space Station!!! Surely astronauts contributed enough to get authorship?! #science #MicroSky #ClinMicro #phages #UTISky

RE: https://bsky.app/profile/did:plc:5522ztebtekoor5efelihqhb/post/3mcfm5qyhep2c

Microbiology in space aboard the International Space Station!!! Surely astronauts contributed enough to get authorship?! #science #MicroSky #ClinMicro #phages #UTISky

RE: https://bsky.app/profile/did:plc:5522ztebtekoor5efelihqhb/post/3mcfm5qyhep2c

Microbiology in space aboard the International Space Station!!! Surely astronauts contributed enough to get authorship?! #science #MicroSky #ClinMicro #phages #UTISky

RE: https://bsky.app/profile/did:plc:5522ztebtekoor5efelihqhb/post/3mcfm5qyhep2c

test #UTISky feed (anyone else please ignore this message!)

Gepotidacin provides #UTI symptomatic relief comparably to nitrofurantoin (in people with uncomplicated UTI in trials) #UTISky #IDSky #ClinMicro #MedSky @[email protected] academic.oup.com/cid/advance-...

Early symptom response in pati...

Great to see this out: new IDSA guidelines on management of complicated UTI. Listened to excellent @[email protected] podcast with @[email protected] @[email protected] @[email protected] & Valéry Lavergne earlier this year explaining how it was put together! #UTISky #IDSky

Clinical Practice Guideline by...

Still trying to get my head round what this model is predicting, as usually at least some clinical information is provided with microbiology samples. #AI #IDSky #ClinMicro #UTISky #AMR @[email protected] academic.oup.com/jac/advance-...

Machine learning for personali...

Can't say I've even ever heard of cefdinir, probably cos we can't get it. But maybe we don't want it anyway! 😉 👇 #IDSky #ClinMicro #UTISky

RE: https://bsky.app/profile/did:plc:hczgnomn6gxwalzjrskgl4hc/post/3m3vl2y7n5c2y

This popped up in my @cmijournal.bsky.social email today. Had read but forgotten about the ImpresU study. Methenamine reduces recurrent UTI but its cessation results in a paradoxical rebound beyond control. Mechanism? 🤔 #IDSky #UTISky www.clinicalmicrobiologyandinfection.org/article/S119...

Methenamine hippurate as proph...

Somehow forgot to share this post this week. Was fun event, well attended (70+ people!), honour to be asked to present, and expertly chaired by @anniejoseph.bsky.social Onto the next one! 👏 #IDSky #UTISky @escmid.bsky.social

RE: https://bsky.app/profile/did:plc:iuu7h4phnqvxwkiv36wbu4ll/post/3m33lim74xk27

There's going to be more and more of this kind of stuff coming through - #AI (a.k.a. machine learning?) algorithms going up against humans. What's the gold standard though? #UTISky #IDSky academic.oup.com/cid/advance-...

Comparing generative artificia...

Good study even if the effective intervention not intuitive at first (to me, anyway). Basically, "conditional reflex urine culturing" = not culturing urine samples with WCC <10 👉 less antibiotic use and urine culture requests overall. #IDSky #ClinMicro #AMR #MedSky #UTISky @cidjournal.bsky.social

Implementation of Diagnostic S...

🎯 Interesting recurrent UTI study with intriguing results: Methenamine (Hiprex): - Starting 👉 ⤵️ frequency of rUTIs in older women -Stopping 👉 ⤴️ risk of UTI relapses Many questions: - mechanism? - change symptom perception? - rebound seen also in other Rx? #UTISky #IDSky @cmijournal.bsky.social

Methenamine hippurate as proph...

V nice study this. VRE growth in gut microbiome relies on different short chain fatty acids, which are themselves modulated by antibiotic exposure. Complex but important to understand how antibiotic resistant bacteria persist in microbiome @natcomms.nature.com 🧪 #AMR #ClinMicro #IDSky #UTISky

RE: https://bsky.app/profile/did:plc:rqryxquav4uac63sfn4qdmqh/post/3ltn7s3yzz22v

Vancomycin-resistant enterococ...

A bit similar to the way fosfomycin can be used, as in in this RCT by @marcbonten.bsky.social (2/2) #IDSky #UTISky

Fosfomycin Vs Ciprofloxacin as...

Pivmecillinam role in treating uncomplicated UTI is established (esp for many AmpC/ ESBL bacteria). I wonder if it also has a place in pyelonephritis care. Perhaps as an oral step down once bacillary burden has fallen? (1/2) #IDSky #UTISky #MedSky #AMR

Pivmecillinam for Treatment of...

Annoying that I negated to paste in the key antibiotic resistance over time plots!🤦‍♂️ #DSky #ClinMicro #UTISky #AMR #medsky

Nice data. To me the coolest, tho also most alarming, is slope of antibiotic resistance declining over time - gradient is shallow! So that means if UTIs recur frequently, you can see how you burn through antibiotic options quickly! #UTISky #IDSky #ClinMicro #AMR academic.oup.com/jac/advance-...