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#idsky — Public Fediverse posts

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  1. New paper out in @[email protected]

    Children born during the pandemic were exposed to a lesser degree to respiratory infections, we have investigated what happened to them.

    #episky #idsky #publichealth #epidemiology

    Post-pandemic respiratory infe...

  2. Disappointing data on meningitis vaccine preventing Neisseria gonorrhoea infections

    Then again negative trial data is as useful as positive findings, so that we focus resources most effectively
    #IDSky www.nejm.org/doi/full/10....

    Meningococcal B Vaccine to Pre...

  3. "As longevity increases in Southern Africa, healthy-ageing interventions for tuberculosis survivors could improve function and survival into older age." #TBSky #IDSky by @[email protected] & team academic.oup.com/jid/advance-...

  4. The fine balance of prophylactic antibiotics. Prevent infections but are these infections significant and at what cost (resistance)? Here in stem cell transplants, but also relevant to other settings #IDSky #UTISky #AMR #ClinMicro academic.oup.com/ofid/advance...

    Effect of quinolone prophylaxi...

  5. "In this proof-of-concept study, 4 months of delamanid, bedaquiline, and quabodepistat showed a promising end-of-treatment non-inferiority signal versus 6 months of RHEZ and was generally well tolerated." @[email protected] #IDSky #TBSky www.thelancet.com/journals/lan...

    Efficacy and safety of a 4-mon...

  6. Without fail, lack of time drifts me away from this platform, then I return and spot lots of good work content, and then rue not being here more and wonder what I've missed! 🤦‍♂️🤷‍♂️ #IDSky #ClinMicro #UTISky #TBSky #AcademicSky

    Danny McNamara Says Everytime

  7. So good. Have spent years fighting this fight, with hand tied behind my back by lack of great evidence. This study is going to get quoted and cited in microbiology MDTs the world over +++ #IDSky #ClinMicro #AMR

    RE: https://bsky.app/profile/did:plc:klwvdtksagcziyylwqukjgal/post/3mlsq453bqk2e

  8. Agree re potentially practice changing. Will be interesting to see if/when its performance gets tested in identifying asymptomatic (but probably infectious) TB cases. Could have even bigger impact on transmission and lowering case numbers. #IDSky #TBSky

    RE: https://bsky.app/profile/did:plc:skpxj6dpacrxznfvwrpfdiw4/post/3mkqrvxs26c2w

  9. Interesting description of heteroresistance to piptaz, but from a highly monitored patient in a clinical trial. And was not associated with treatment failure Most patients don't have post-antibiotic microbiology samples, so maybe this happens commonly (& inconsequentially) #IDSky #ClinMicro #UTISky

    RE: https://bsky.app/profile/did:plc:l7hoy6b4k4tuwysko34jriwi/post/3mko2f3cdxc2i

  10. i should add, finding it was triggered by this very good commentary (with a good title) #TBSky #IDSky www.nature.com/articles/s41...

    The ghost of tuberculosis past...

  11. I think i'd missed this. Generates many hypotheses (in my head anyway) on the biological pathways that may be underlying this increased risk of death for many years after TB diagnosis & treatmnent. #IDSky #TBSky www.nature.com/articles/s41...

    Long-term risk of death after ...

  12. Important piece of work that guides much of our OPAT practice in UK. It's also impressive in its acceptance of the evidence. Literally the guideline for use of IV antibiotics is advocating for use of oral antibiotics instead! 👏 #IDSky #ClinMicro #AMR #OPAT

    RE: https://bsky.app/profile/did:plc:l7hoy6b4k4tuwysko34jriwi/post/3mk62wkqymc27

  13. Of note, TB helps here - turnaround time not THAT fast (still 16 days from positive culture to WGS guided treatment recommendations), but it's a slow disease. Not easily applicable to all other infections #TBSky #IDSky #ESCMIDGlobal2026 (2/3)

  14. I need to print this and frame it in my office!!! And then look at it before I reply to some emails... 🫣😞😂 #IDSky #AcademicSky

    RE: https://bsky.app/profile/did:plc:cchjsgmpzt7k2uiz3tqvscoy/post/3mjvurtobks2p

  15. Nice vision by Nicholas Paton for TB treatment in the future. 8 week oral treatment followed by long-acting injectable that could be antimicrobial +/- host-directed. Definitely a post to come back to in 5-10 years' time! #ESCMIDGlobal2026 #IDSky #TBSky

  16. Recent nice paper @[email protected] looked at this: radiolgical changes (not culture) in asymptomatic contacts predictive of risk of TB disease development. PET-CT best but CXR not bad and feasible. @[email protected] www.thelancet.com/journals/lan... #IDSky #TBSky #ESCMIDGlobal2026 (2/2)

  17. Excellent talk from Hanif Esmail on asymptomatic TB. Around half of M tuberculosis culture positive patients have no symptoms & probably contributes to transmission. Who should we offer treatment to? #TBSky #IDSky #ESCMIDGlobal2026 (1/2)

  18. For those that don't know (included me!), Gremubamab binds specifically to the Pseudomonas aeruginosa PcrV protein and the Psl exopolysaccharide. Both are virulence factors used for adhesion and biofilm stability. Thanks @[email protected] ! #ESCMIDGlobal2026 #IDSky #ClinMicro

    RE: https://bsky.app/profile/did:plc:jh6ykfvllrvxnubjpzazm2vb/post/3mjr55jvdxc2u

  19. "Among 5121 participants assessed, 1573 (30.7%) underwent DOC, of which 1502 (95.5%) were delabeled." - that's a lot of penicillin allergy mislabelling out there! 😲 However... DOC.. more likely to be prescribed penicillin and less likely WHO “Watch” or “Reserve” antibiotics #IDSky #ClinMicro #AMR

    Direct Oral Challenge for Peni...