#immunosky — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #immunosky, aggregated by home.social.
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Fascinating paper. Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease. But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link? #immunosky #MedSky www.nejm.org/doi/full/10....
Interleukin-10 Autoantibodies ... -
this is cool - haematopoietic stem cell subsets that remember inflammatory cues. Link to human disease mortality a bit loose, personally, and not much functional readout of progenitor cells. Still, paper concept interesting, and yet another single cell popn to hunt in own datasets.... #ImmunoSky
RE: https://bsky.app/profile/did:plc:vt765hjdontyunsxk7bslksv/post/3mn3dyhzm7s2h -
Nice demonstration by @[email protected] et al that some, but not all, non tuberculous mycobacteria (NTM) intracellular growth in macrophages is pH sensitive #TBSky #immunosky onlinelibrary.wiley.com/doi/10.1111/...
Acidic pH Restricts Non‐Tuberc... -
This is really rather cool - macrophages nibbling live cells to maintain immune tolerance. A must for journal club soon... #immunosky
RE: https://bsky.app/profile/did:plc:px3rjj3utp3bkfchk2vmqm5p/post/3mknf2p62rs2c -
Love this - all marketing is good marketing. Even immune markers have an age and significant milestones. CD40 - important molecule - not to be sniffed at! #ImmunoSky
RE: https://bsky.app/profile/did:plc:czhpd6buktkiv23zghhohq22/post/3mk3kkino7m2n -
Great progress on vaccines & host-directed therapies (HDT) in TB. Our review on IL-17👇 🎯protective early on & post-vaccine in animal models 👉desirable for vaccines? 🎯Drive pathology in TB disease👉target for HDT to limit post-TB lung damage? With @[email protected] @[email protected] #TBSky #ImmunoSky
Context-specific roles for IL-... -
Epithelial host pathogen interactions are complex! Happy to have contributed to this work, showing how mutations in Streptococcus pneumoniae biosynthesis genes results in divergent phenotyoic effects and host transcriptional responses (the bit I did!) #IDSky #immunosky @[email protected]
Disease-Attenuated Pneumococca... -
More adjunctive immunomodulation for an infectious disease! Here it's dupilumab (IL-4/13 blockade) in coccidioidomycosis. Case series only, but not overtly harmful and maybe even helpful. #IDSky #immunosky academic.oup.com/cid/advance-...
Immunomodulation in the Treatm... -
Love this kind of science. Human integrin LFA-1 considered important for T cell skin homing. But how important is it really? Looking at genetic deficient individuals, turns out LFA-1 essential for clearing commensal papillomaviruses, but redundant for most else! @[email protected] #ImmunoSky
Human LFA-1 governs T cell imm... -
This is a very appealing meeting in Paris later this year... "The complexity of mycobacterial infections: from research to real-world impact" #EMBOComplexInfections #TBSky for the tuberculosis research, but also #NTM #Leprosy #IDSky #ImmunoSky meetings.embo.org/event/26-myc...
The complexity of mycobacteria... -
IL-23 is a highly targeted cytokine vs autoimmune disease. But here with an oral agent! @nejm.org #ImmunoSky #MedSky www.nejm.org/doi/full/10....
Oral Icotrokinra for Plaque Ps... -
Host-directed therapies for infectious disease are here & coming! Simple equation proposed to consider best interventions: ⭐ Microorganism + immune response = clinical presentation/status ⭐ Will require futuristic-sounding real-time diagnostics = exciting! #IDSky #MedSky #ImmunoSky #TBSky
The Changing Paradigm in Infec... -
There you go - TB shaping the immune system (MHC class II) of meerkats! #TBSky #ImmunoSky 🧪 www.nature.com/articles/s41...
Twenty years of tuberculosis-d... -
Speed conference dating @ #IUIS2025! 😅 #ImmunoSky
RE: https://bsky.app/profile/did:plc:lejmggi35is2bys7mwc5pjc2/post/3lwqkgfmjmt2f -
I think someone accidentally copied and pasted "Manuscript title:" into the title field! 🤭 (also quite an interesting #malaria immunology study!) #IDSky #ClinMicro #medsky #immunosky #AcademicSky academic.oup.com/jid/advance-...
Manuscript title: Cytokines As... -
Another immune mechanism in TB in which a seemingly host protective response (immunothrombosis) may get out of hand and drive tissue pathology. @jidjournal.bsky.social #IDSky #TBSky #ImmunoSky 🧪
The emerging role of immunothr... -
As paper titles involving TB go, this one using the rhyming Fc is not bad... (also a good synopsis of an important paper) #IDSky #TBSky #immunosky www.science.org/doi/10.1126/...
TB or not TB: That depends on ... -
This is good news. Comparable immune responses (IgA & neutralising antibodies) with new oral polio vaccine compared to Sabin vaccine - hopefully can help interrupt circulating vaccine-derived poliovirus outbreaks. @lancetmicrobe.bsky.social #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Intestinal mucosal immune resp... -
I honestly thought it was a given that neutrophil elastase was important in controlling Staph aureus infection! @jidjournal.bsky.social #immunosky academic.oup.com/jid/advance-...
Neutrophil elastase limits spr... -
And TBH @europepmc.org has more & better features, like @altmetric.com integration for one! #MedSky #immunosky #IDSky #AcademicSky
RE: https://bsky.app/profile/did:plc:a4mdbabyn4u3yxzh5o7hzlxl/post/3ljdh7ckzs22q -
The evidence is overwhelming. Denying viruses is denying reality. Science works. If you’re unsure, follow experts in virology, immunology, molecular biology, and epidemiology, not conspiracy theories.
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Immune evasion through mitochondrial transfer in the tumour microenvironment
Identification of mitochondrial DNA (mtDNA) mutations in TILs that are shared with cancer cells, and are derived from the tumour cells.
#ImmunoSky #MedSky -
Precursors of exhausted T cells are preemptively formed in acute infection
At that stage early precursors show diversity; memory T cells but also cells with a phenotype, gene-expression, and epigenetic profile that resembles precursors of exhausted T cells. #ImmunoSky
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🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)
Altered IL-6 signalling and ri... -
Cool new paper - lockdowns have indirect immunological consequences on disease susceptibility 👏 @apsmunro.bsky.social & @tah-sci.bsky.social #IDSky 🩺 #virology #MicroSky #ImmunoSky academic.oup.com/cid/advance-...
Cycles of susceptibility: Immu... -
MicroRNAs won the Nobel — will they ever be useful as medicines? #Science #MedSky #ImmunoSky www.nature.com/artic...
MicroRNAs won the Nobel — will... -
'Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α, -β, and/or -ω can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition.'
