#myocardial — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #myocardial, aggregated by home.social.
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Myocardial infarction: self amplifying RNA for heart protective hormone delivered by intramuscular injection of lipid nanoparticles. Encouraging results in animal trials. https://www.science.org/doi/abs/10.1126/science.adu9394?af=R
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Why Does COVID-19 Cause Severe Illness in Some Patients but Not Others?
Factors linked to disease outcomes included viral load, frequencies of certain cell types such as #cytotoxic #natural #killer (#NK) cells, various #inflammatory #states, and markers of #myocardial #damage.
In participants who died of the infection, #viral #loads persisted and even started to rise over time. By contrast, viral loads steadily declined in those with milder infections.
The activation of cell types such as cytotoxic NK cells increased in the milder cases as participants’ immune systems ramped up in response to the infection, while these cells decreased in the more severe groups.
Furthermore, participants who were sickest had higher levels of inflammatory markers upon hospitalization that increased over time, while patients in the milder groups showed an opposite pattern
< Yale School of Medicine
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A common cause of #myocardial #infarction and #stroke is the rupture of #atherosclerotic plaques. The exact location of plaque ruptures has previously been unknown, but now researchers at Lund University have mapped this.
#Medical #sflorg
https://www.sflorg.com/2023/06/med06122302.html -
A short news story I wrote reporting on a study that found the shape of your #heart can help predict risk for atrial fibrillation.
The first few paragraphs (most of the story):Rounder hearts predict future heart failure, a-fib
Greater left ventricular sphericity showed 47% greater incidence of #cardiomyopathyMAY 2023 -- Not everyone’s heart is quite the same shape and its shape changes over time – but this could help predict who’s at risk for #cardiomyopathy.
A study in CellPress, where researchers analysed cardiac MRIs of over 30,000 people, found that variations in left ventricle sphericity in normal hearts predicted risk for cardiomyopathy and related outcomes.
Researchers hypothesized that beyond size and function, the shape of hearts might carry extra details about heart health. To study this, they used data from a large biobank with cardiac imaging data to help analyze variation in cardiac morphology in normal populations.
They noted “Cardiomyopathies of different etiologies often result in a similar end-stage phenotype of a more round, spherical ventricle. Among individuals with known cardiac disease, increased sphericity of the left ventricle (LV) has been associated with adverse outcomes, including ventricular arrhythmias and death.”
It also stated that “within the spectrum of normal LV chamber size and systolic function, there exists variation in LV sphericity, and this variation may be a marker of cardiac risk with genetic underpinnings.”
The researchers turned to artificial intelligence to help analyze 38,897 cardiac MRIs from the U.K. Biobank database. The cohort had undergone cardiac MRIs and had normal LV end-diastolic volume, normal LV end-systolic volume, and normal LV ejection fraction.
The team looked at LV sphericity and whether it predicted incident cardiomyopathy as well as clinical manifestations such as atrial fibrillation, heart failure, and #cardiac arrest. Other factors were taken into account such as body mass index, pulse rate, #hypertension, diabetes, and prior #myocardial infarction.
“We found that individuals with spherical hearts were 31% more likely to develop atrial fibrillation and 24% more likely to develop cardiomyopathy,” said Dr. David Ouyang in a press release. He is coauthor of the study and a cardiologist at Cedars Sinai in California....
The full story is online. Sorry, its password protected. It's accessible, free to #doctors and #pharmacists #myocardial #medicine #MedicalPost #MedMastodon #cardiology @medmastodon
MY NEWS REPORT: https://www.canadianhealthcarenetwork.ca/rounder-hearts-predict-future-heart-failure-fib
THE STUDY: https://www.cell.com/action/showPdf?pii=S2666-6340%2823%2900069-7
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Inflammation associated with invasive pneumococcal disease the unifying mechanism? #sepsis #infection #MI #myocardial #infarction #medicine #IDMastodon
Risk of acute myocardial infarction among patients with laboratory-confirmed invasive pneumococcal disease: a self-controlled case series study | Clinical Infectious Diseases | Oxford Academic
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad065/7030946
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It's been described in the past, but I'm always a bit astonished to see that sub-gingival #pathobionts 🦷 associate with #myocardial infarction risk 💔.
Testing 160 acute MI patients with varying degrees of clinical #periodontitis enrolled in this cross-sectional study, authors link increased abundance of subgingival #Porphyromonas gingivalis and overexpression of virulence factors to worse cardiac outcomes and CAD burden.