#idmastodon — Public Fediverse posts

May have shared this before. Some evidence of IL-6 hyperinflammation in people living with #HIV
#tocilizumab #IDMastodon #infectiousdiseases #microbiology #medicine

Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection https://academic.oup.com/cid/article/77/2/272/7100622?login=true

Steroids are very effective immunomodulating drugs. BUT they do increase the risk of some infections.

This is a nice review describing what infections steroids make you susceptible. The immunology affected is discussed but harder to pin down, as likely context dependent.
#corticosteroids #steroids #medicine #infections #infectiousdiseases #IDMastodon #immunology #opportunisticinfections #PCP #HBV #VZV #zoster #CMV
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad474/7260874?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner#415942086

Pretty exciting to see oral amphotericin behaving comparably to IV amphotericin for #HIV associated #Cryptococcus #meningitis

Phase 2 open label #RCT, so not quite there yet, but big potential win in simplicity and access to treatment for
#Cryptococcusneoformans & other #fungal diseases, potentially even #mucor

#infectiousdiseases #mycology #IDMastodon #MedMastodon #medicine @infectiousdiseases

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad440/7246927

Open access eBook from the VALIDATE vaccine network:

#Vaccines for neglected pathogens: strategies, achievements and challenges: focus on #Leprosy, #Leishmaniasis, #Melioidosis and #Tuberculosis

#IDMastodon #NTDs

https://link.springer.com/book/10.1007/978-3-031-24355-4

I had never heard of melatonin as a way to prevent renal injury with colistin!

Didn't work in this RCT, although stopped early as ran out of colistin during #COVID19! 😔

#IDMastodon #AMR #antibiotics #antimicrobialstewardship #Renal #Colistin #PolymixinB

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00641-3/fulltext?dgcid=raven_jbs_aip_email