#idmastodon — Public Fediverse posts

This sounds like a really interesting book.
"A HISTORY OF THE WORLD IN SIX PLAGUES: HOW CONTAGION, CLASS, AND CAPTIVITY SHAPED US,
FROM CHOLERA TO COVID-19."

It focuses on six disease crises from the 19th century to the present—cholera, HIV/AIDS, the Spanish flu, sleeping sickness, Ebola, and #COVID-19.

#history #medicine #medmastodon @medmastodon #IDmastodon #infectious #pandemic #endemic #lockdown #quarantine
https://www.nasw.org/member_article/edna-bonhomme-history-world-six-plagues-how-contagion-class-and-captivity-shaped-us

A nasty, rare mosquito-borne disease popped up in a human case #Massachusetts. Not West Nile but a different one. (But #WestNile is around too)

@medmastodon #Medmastodon #IDmastodon #infectiousdiseases #infectious #brain https://ca.news.yahoo.com/rare-deadly-mosquito-virus-concerning-163854630.html

My new story for the Medical Post/Canadian Healthcare Network.
#Doctors and #pharmacists in Canada can log on for free. Here are a few paragraphs.

Could a century old treatment be an answer to antibiotic resistance?
In a first in Canada, a patient with an #antibiotic resistant artificial joint infection has received treatment with phage therapy and is showing promising early responses.

“This is cutting edge stuff, and a potentially new technology,” said Dr. Marisa Azad, the infectious diseases physician who treated the patient. She is also an assistant professor of medicine at the University of Ottawa.

The patient presented with severe periprosthetic joint infection (PJI) in the summer of 2023. She had already undergone multiple surgeries and had experienced several relapses and infections with the same persistent bacteria.

“She’d been on multiple very prolonged courses of antibiotics and had a severe drug allergy to two major drug classes of antibiotics. I was extremely limited in what I could use to treat her,” Dr. Azad told the Medical Post in an interview.

That’s when the idea arose of trying an experimental treatment course with phage therapy. The team got approval for doing the experimental treatment from Health Canada, and worked with Winnipeg-based Cytophage, which supplied the phages.

“We developed a protocol and gave her therapy over two weeks while she was admitted to hospital. She’s completed her therapy. Now we’re monitoring her closely and giving her adjunctive antibiotics,” she said.

The idea didn’t come out of the blue. In the medical literature, a study from just last year in Clinical #Infectious Diseases provided a review of 33 previously published cases of patients with end-stage, refractory bone and joint infections (BJI) who underwent treatment with phage therapy. The authors found that from those case reports, “29 (87%) achieved microbiological or clinical success, two (5.9%) relapsed with the same organisms, and two (5.9%) with a different organism” with no serious adverse events.

The conclusions of that paper stated there were “important advantages, disadvantages, and barriers to the implementation of phage therapy for BJIs.” Yet, at the same time, the authors added they, “believe that if phage therapy were to be used earlier in the clinical course, fewer cumulative antibiotics may be needed in an individual treatment course.”

The word phage is short for #bacteriophage, a word coined in 1917—literally meaning bacteria-eater. They are viruses whose lifecycle depends on certain types of bacteria.

“They latch on to specific types of bacteria and inject their genetic material into the bacterial cell." Dr. Azad explained. "They take over the bacterial cells’ machinery to produce more little viruses inside and explode or burst open the bacteria,” releasing viral particles that can go and infect other cells of the same type of bacteria.

Intriguingly, each #phage targets a specific type of #bacteria...
The story of phages started over 100 years ago. They were independently discovered, first in 1915 by a British pathologist, Frederick Twort, and then again in 1917 by French-Canadian microbiologist Felix d’Herelle. And...

#MedMastodon #IDmastodon #microbiology @medmastodon
https://www.canadianhealthcarenetwork.ca/could-century-old-treatment-be-answer-antibiotic-resistance

Risk of death following chikungunya virus disease in the 100 Million Brazilian Cohort, 2015–18: a matched cohort study and self-controlled case series

Thiago Cerqueira-Silva et al.

February 08, 2024

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00739-9/fulltext

#Brasil
#IDMastodon
#Chikungunya
#Arboviruses

Interested in TB? Interested in HLH?

Then check out our systematic review & meta-analysis on TB-associated cases of HLH.

Fab collaboration BETWEEN clinical research teams at UCL & @Radboud_uni

#medicine #infectiousdiseases #IDMastodon #HLH #inflammation #TB #tuberculosis

So what did we find?🧵👇

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad697/7516258?utm_source=advanceaccess&utm_campaign=ofid&utm_medium=email 1/6

Persistent Enterococcal Bacteremia is a challenge. How best to manage?

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad612/7453726?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner

#IDMastodon #infectiousdiseases #microbiology #medicine #endocarditis #bacteremia

Our meta-analysis of TB-associated HLH looking at diagnostics & outcome will be presented by Lisa Kurver at #TBScience e-poster @UnionConference #UnionConf2023 4pm Salle Maillot 5. Preprint 👇
https://www.medrxiv.org/content/10.1101/2023.11.14.23298501v1
#TB #tuberculosis #HLH #IDMastodon #infectiousdiseases #medicine

Chickenpox vaccine should be given to children on NHS, JCVI says

#vaccine #vaccination #infectiousdiseases #IDMastodon #medicine #chickenpox #varicella #VZV

https://www.theguardian.com/society/2023/nov/14/chickenpox-vaccine-should-be-given-to-children-on-nhs-jcvi-says?CMP=Share_AndroidApp_Other

> Until now, UK has said that jab could increase risk of chickenpox and shingles in adults

Chickenpox vaccine should be given to children on NHS, JCVI says

#vaccine #vaccination #infectiousdiseases #IDMastodon #medicine #chickenpox #varicella #VZV

https://www.theguardian.com/society/2023/nov/14/chickenpox-vaccine-should-be-given-to-children-on-nhs-jcvi-says?CMP=Share_AndroidApp_Other

> Until now, UK has said that jab could increase risk of chickenpox and shingles in adults

Chickenpox vaccine should be given to children on NHS, JCVI says

#vaccine #vaccination #infectiousdiseases #IDMastodon #medicine #chickenpox #varicella #VZV

https://www.theguardian.com/society/2023/nov/14/chickenpox-vaccine-should-be-given-to-children-on-nhs-jcvi-says?CMP=Share_AndroidApp_Other

> Until now, UK has said that jab could increase risk of chickenpox and shingles in adults

Chickenpox vaccine should be given to children on NHS, JCVI says

#vaccine #vaccination #infectiousdiseases #IDMastodon #medicine #chickenpox #varicella #VZV

https://www.theguardian.com/society/2023/nov/14/chickenpox-vaccine-should-be-given-to-children-on-nhs-jcvi-says?CMP=Share_AndroidApp_Other

> Until now, UK has said that jab could increase risk of chickenpox and shingles in adults

Chickenpox vaccine should be given to children on NHS, JCVI says

#vaccine #vaccination #infectiousdiseases #IDMastodon #medicine #chickenpox #varicella #VZV

https://www.theguardian.com/society/2023/nov/14/chickenpox-vaccine-should-be-given-to-children-on-nhs-jcvi-says?CMP=Share_AndroidApp_Other

> Until now, UK has said that jab could increase risk of chickenpox and shingles in adults

One potential explanation for low level #HIV viral load in patients that are otherwise fully compliant with #antiretrovirals / #ARV / #ART

CD4 T cells that persist and reduced CD8 T cell activity. Question is, is this host or viral mediated?
#medicine #MedMastodon #IDMastodon #infectiousdeseases

https://www.nature.com/articles/s41591-023-02611-1

Less is more - don't add Vancomycin unless you need to in surgical prophylaxis.

(better, use teicoplanin, but many countries don't have it!)

#AMR #antibiotics #IDMastodon #infectiousdiseases #medicine #surgery #prophylaxis #MRSA

Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty

https://www.nejm.org/doi/full/10.1056/NEJMoa2301401?query=TOC&cid=NEJM%20eToc,%20October%2019,%202023%20DM2292852_NEJM_Non_Subscriber&bid=1868113537

Great review in NEJM on Shiga Toxin–Producing Escherichia coli and the Hemolytic–Uremic Syndrome

Excellent combination of #pathophysiology & #clinical risk stratification (see figures below for summary)

#IDMastodon #infectiousdiseases #microbiology #medicine #Ecoli #HUS https://www.nejm.org/doi/full/10.1056/NEJMra2108739?query=TOC&cid=NEJM%20eToc,%20October%2012,%202023%20DM2290876_NEJM_Non_Subscriber&bid=1851470135

Herpes Simplex Dendritic Keratitis

#ophthalmology #viruses #HSV #cornea #medicine #IDMastodon #infectiousdeseases #virology

https://www.nejm.org/doi/full/10.1056/NEJMicm2302973

Sensitivity of the #SARS-CoV-2 #BA286 #variant to prevailing neutralising #antibody responses, Lancet Infect Dis.: https://doi.org/10.1016/S1473-3099(23)00588-1 #research #science #immunity #library #IDMastodon #pandemic #VOIs

"Host cell environments and antibiotic efficacy in tuberculosis"

Nice figure showing the challenges of #antibiotics to get into a cell and target #Mycobacterium tuberculosis

#tuberculosis #TB #IDMastodon #infectiousdiseases #immunology
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(23)00253-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0966842X23002536%3Fshowall%3Dtrue

CPE and plasmid transfer in hospitals – what can we do? A rapid reflection from ICPIC 2023
#AMR #microbiology #plasmid #CRO #CPE #IDMastodon #infectiousdeseases #infectioncontrol

https://reflectionsipc.com/2023/09/14/cpe-and-plasmid-transfer-in-hospitals-what-can-we-do-a-rapid-reflection-from-icpic-2023/

It is so hard to manage infections when the anatomy is not intact

Here in infants with Vesicoureteric Reflux. Give antibiotic prophylaxis:
👉 less UTIs
👉 more antibiotic resistance

Not a straightforward trade-off given the many courses of antibiotic ahead of these young people's lives...
#AMR #IDMastodon #infectiousdiseases #pediatrics #microbiology #antibiotics #reflux #UTI
https://www.nejm.org/doi/full/10.1056/NEJMoa2300161?query=TOC&cid=NEJM%20eToc,%20September%2014,%202023%20DM2283617_NEJM_Non_Subscriber&bid=1796877798

Whole-genome sequencing for pathogen identification is perceived as the way forward. But is it cost effective?

#genomics #microbiology #infectiousdiseases #publichealth #IDMastodon #medicine #laboratoryscience #diagnostics #pathogens

https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00180-5/fulltext?dgcid=raven_jbs_aip_email

Steroids are very effective immunomodulating drugs. BUT they do increase the risk of some infections.

This is a nice review describing what infections steroids make you susceptible. The immunology affected is discussed but harder to pin down, as likely context dependent.
#corticosteroids #steroids #medicine #infections #infectiousdiseases #IDMastodon #immunology #opportunisticinfections #PCP #HBV #VZV #zoster #CMV
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad474/7260874?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner#415942086

Steroids are very effective immunomodulating drugs. BUT they do increase the risk of some infections.

This is a nice review describing what infections steroids make you susceptible. The immunology affected is discussed but harder to pin down, as likely context dependent.
#corticosteroids #steroids #medicine #infections #infectiousdiseases #IDMastodon #immunology #opportunisticinfections #PCP #HBV #VZV #zoster #CMV
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad474/7260874?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner#415942086

Steroids are very effective immunomodulating drugs. BUT they do increase the risk of some infections.

This is a nice review describing what infections steroids make you susceptible. The immunology affected is discussed but harder to pin down, as likely context dependent.
#corticosteroids #steroids #medicine #infections #infectiousdiseases #IDMastodon #immunology #opportunisticinfections #PCP #HBV #VZV #zoster #CMV
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad474/7260874?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner#415942086

Steroids are very effective immunomodulating drugs. BUT they do increase the risk of some infections.

This is a nice review describing what infections steroids make you susceptible. The immunology affected is discussed but harder to pin down, as likely context dependent.
#corticosteroids #steroids #medicine #infections #infectiousdiseases #IDMastodon #immunology #opportunisticinfections #PCP #HBV #VZV #zoster #CMV
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad474/7260874?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner#415942086

Steroids are very effective immunomodulating drugs. BUT they do increase the risk of some infections.

This is a nice review describing what infections steroids make you susceptible. The immunology affected is discussed but harder to pin down, as likely context dependent.
#corticosteroids #steroids #medicine #infections #infectiousdiseases #IDMastodon #immunology #opportunisticinfections #PCP #HBV #VZV #zoster #CMV
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad474/7260874?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner#415942086

Reminder to pick your outcomes.

Vancomycin vs Fidaxomicin in #Cdiff- same mortality, but lower recurrence with fidaxo
#Clostridiumdifficile #antibiotics #microbiology #IDMastodon #infectiousdeseases

The Effect of Antibiotic Therapy for Clostridioides difficile Infection on Mortality and Other Patient-Relevant Outcomes: a Systematic Review and Meta-analysis - Clinical Microbiology and Infection https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00420-2/fulltext

Timely report during a late #summer #heatwave in the #UK

#mosquitoes #westnilevirus #culex #infectiousdiseases #IDMastodon #medicine #ClimateChange

https://news.sky.com/story/climate-change-longer-warmer-summers-could-increase-risk-of-mosquitoes-carrying-fatal-diseases-in-the-uk-experts-say-12955020

Oh good, cos this is exactly what we do.

In #Clostridiumdifficile diarrhoea, we treat NAAT+ve, / toxin - ve if they have #diarrhea and no obvious reason for it.

#IDMastodon #MedMastodon #medicine #infectiousdiseases

Clinical Outcomes and Management of NAAT-Positive/Toxin-Negative Clostridioides difficile Infection: A Systematic Review and Meta-Analysis | Clinical Infectious Diseases | Oxford Academic

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad523/7256092

ESCMID guidelines on diagnosis and treatment of brain abscess in children and adults - Clinical Microbiology and Infection

#IDMastodon #MedMastodon #AMR #antibiotics #microbiology #antimicrobialstewardship #infectiousdiseases #medicine @infectiousdiseases @microbiology #brain #abscess

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00399-3/fulltext?dgcid=raven_jbs_aip_email

"The most frequently reported reasons for hesitancy among #pregnant and #breastfeeding women were concerns about safety of the vaccine for pregnant/breastfeeding women or their baby, the perception of a rapid vaccine development and approval process, and a lack of knowledge/information about the vaccine. As a matter of fact, healthcare professionals’ trust in vaccines and their recommendations to people is of paramount importance" - #ObGynodon & #IDMastodon - https://www.mdpi.com/2076-393X/11/8/1289

This we really don't want to see.

Increase in #Candidaauris cases in bloodstream.

V v hard to treat. Resistant +++
#AMR #microbiology #mycology @microbiology #IDMastodon #infectiousdeseases @infectiousdiseases

Candida auris rates in blood culture on the rise: results of US surveillance

https://journals.asm.org/doi/10.1128/spectrum.02216-23

Long post via Dr. Male of Imperial College / London about the #RSV vaccine... on that other social media platform #IDMastodon #ObGynodon - https://twitter.com/VikiLovesFACS/status/1694336102574800913?s=20

More evidence of #trainedimmunity in #COVID19 / #SarsCoV2 infection leading to #Hyperinflammation

#immunology #virology #infectiousdiseases #IDMastodon #medicine

https://www.cell.com/cell/fulltext/S0092-8674(23)00796-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423007961%3Fshowall%3Dtrue

Pretty exciting to see oral amphotericin behaving comparably to IV amphotericin for #HIV associated #Cryptococcus #meningitis

Phase 2 open label #RCT, so not quite there yet, but big potential win in simplicity and access to treatment for
#Cryptococcusneoformans & other #fungal diseases, potentially even #mucor

#infectiousdiseases #mycology #IDMastodon #MedMastodon #medicine @infectiousdiseases

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad440/7246927

@noodle @infectiousdiseases @microbiology we definitely use it alongside or often after trying methenamine. However, evidence for its efficacy remains scant. This is the best evidence from an open-label #RCT https://link.springer.com/article/10.1007/s00345-013-1091-6
#recurrent #UTI #IDMastodon #infectiousdiseases #medicine #MedMastodon

earlier today the FDA approved a maternal vaccine for prevention of #RSV in newborns... via @HelenBranswell.

#Obgynodon & #IDMastodon
https://www.statnews.com/2023/08/21/pfizer-rsv-vaccine-abrysvo-newborns-fda-approval/

We commonly use #nitrofurantoin to treat #UTI and even sometimes as prophylaxis for recurrent infections.

Super safe #antibiotic but a reminder that rarely it can cause serious complications #lung #fibrosis
@infectiousdiseases @microbiology #IDMastodon #MedMastodon #medicine

Chronic Nitrofurantoin-Induced Lung Injury

https://www.nejm.org/doi/full/10.1056/NEJMicm2214831

"Given the increased risk of hospitalization and death from the co-circulation of #influenza virus and SARS-CoV-2 in vulnerable groups, including #pregnant women, vaccination of pregnant women should be prioritized as a cost-effective intervention."

#ObGynodon & #IDMastodon

https://pubmed.ncbi.nlm.nih.gov/37591411/

“Hepatitis screening during pregnancy is an opportunity to promote a dialogue between pregnant patients and their clinicians about #hepatitis transmission; ongoing and new risk factors; and, if not previously vaccinated, hepatitis B vaccination in #pregnancy"

New guidelines from the American College of Obstetricians and Gynecologists - #Obgynodon & #IDMastodon.

https://www.acog.org/news/news-releases/2023/08/acog-releases-new-guidance-on-viral-hepatitis-in-pregnancy?utm_source=higher-logic&utm_medium=email&utm_content=Aug-18&utm_campaign=acog2023-rounds

"Pandemics are increasingly reported to negatively influence pregnancy outcomes," the study authors wrote. "This urges us to better prepare for future pandemics to mitigate their effects on maternal and neonatal health." #Obgynodon & #IDMastodon

https://www.cidrap.umn.edu/pandemic-influenza/swiss-data-1918-flu-pandemic-show-steep-rise-low-birth-weight-stillbirth

"For example, one study found that people who are vaccine-averse while #pregnant, but happy to adhere to CDC’s recommendations when they’re not, responded well to some simple coaching about why #vaccination was safe and effective" #Obgynodon & #IDMastodon

https://www.washingtonpost.com/business/2023/08/18/vaccines-during-pregnancy-faltered-after-covid-pandemic/5f8b97ec-3dc2-11ee-aefd-40c039a855ba_story.html

Nice review of an study in AJOG. The story of #stillbirth and #Covid continues to evolve, and vaccination prevents this complication - #IDMastodon & #ObGynodon - https://www.contemporaryobgyn.net/view/covid-19-infection-associated-with-fetal-demise

"Pregnant participants who received a booster dose had substantially more antibodies against SARS-CoV-2, both in their own blood and in their cord blood, suggesting that boosting also increased their newborns’ immune defenses against #COVID19." #obgynodon + #IDMastodon https://www.nih.gov/news-events/news-releases/covid-19-vaccination-boosting-during-pregnancy-benefits-pregnant-people-newborns?utm_source=dlvr.it&utm_medium=twitter

A large prospective study of #influenza vaccination during #pregnancy is in this month's edition of "Obstetrics and Gynecology." Conclusion - "Influenza vaccination before or during pregnancy was not associated with miscarriage."

#obgynodon & #IDMastodon
https://journals.lww.com/greenjournal/Fulltext/9900/Risk_of_Miscarriage_in_Relation_to_Seasonal.842.aspx

"The prevalence of maternal #hepatitis C virus infection has significantly increased in the U.S. since the start of the opioid epidemic in 1998" - I think I may have already posted this #ObGynodon & #IDMastodon but #WorldHepatitisDay was last week. https://www.healio.com/news/womens-health-ob-gyn/20230731/hcvpositive-pregnancies-in-us-increased-16fold-from-1998-to-2018

Another huge #HPV vaccination study from Scandinavia, this time with > 2 million subjects in Norway. The HPV #vaccine was most effective against anogenital warts when given during teen years. #IDMastodon & #ObGynodon

New virulence factor for uropathogenic E coli. Interesting link to induction of "stronger" immune response - cause or effect?
#Ecoli #UPEC #uropathogenic #UTI #urology #microbiology #infectiousdeseases #IDMastodon

HlyF, an underestimated virulence factor of uropathogenic Escherichia coli - Clinical Microbiology and Infection

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00352-X/fulltext?dgcid=raven_jbs_aip_email

Some evidence of a genetic predisposition for hyperinflammation to convert to HLH
#IDMastodon #MedMastodon #immunology #infectiousdisease #HLH #HIV #IRIS #medicine

https://academic.oup.com/jid/article/228/2/111/7114708

Clear trends in hospital Group A strep admissions in UK. ⬇️ during and ⬆️ after #COVID19.

This is national Hospital Episode Statistics , which matches UKHSA data.

Next question: what exactly drove the recent rise?

Hospital admissions for group A streptococcal infections in England: current rates and historical perspective
#GAS #StrepA #GroupAstrep #bacteria #microbiology #IDMastodon #medicine #MedMastodon #infectiousdiseases
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00428-0/fulltext?dgcid=raven_jbs_aip_email