#mitotic — Public Fediverse posts

Researchers reveal how #acetylation regulates #centromere dynamics, #chromosome #segregation and #mitotic progression.

#TIP60 #Bub1

https://phys.org/news/2024-05-reveal-acetylation-centromere-dynamics-chromosome.html

Are there functions specific to #CUL4A and #CUL4B-based #ubiquitin E3 #ligases?

Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy #mitotic #phosphorylation, and promoting recruitment of a specific set of #DCAF substrate receptors involved in #cytoskeleton regulation

https://www.embopress.org/doi/10.15252/embj.2022112847

How do cancer-specific chromosome gains/losses contribute to #oncogenesis?
Susanne Lens and collaborators at UMC Utrecht describe a #kinesin-based strategy for inducing #mitotic #missegregation of selected #chromosomes, as tool for modeling specific #aneuploidies

https://www.embopress.org/doi/10.15252/embj.2022111559

#Mitotic #chromosome condensation contributes to the homeostatic control of #gene #expression #regulation.

https://phys.org/news/2023-02-mitotic-chromosome-condensation-contributes-homeostatic.html