#Aneuploidies are an ancestral feature of #trypanosomatids, and an ancient chromosome #duplication is maintained in extant species
João Luís Reis-Cunha et al
bioRxiv 2023.06.26.546280; doi: https://doi.org/10.1101/2023.06.26.546280
#aneuploidies — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #aneuploidies, aggregated by home.social.
-
-
A #CRISPR-Cas9-tagging approach to induce #chromosome-specific segmental #aneuploidies: targeted assembly of ectopic #kinetochores at endogenous repeats - a way to recapitulate and study specific disease-associated #missegregation events in human cells
@McClellandLab
https://www.embopress.org/doi/10.15252/embj.2022111587 -
How do cancer-specific chromosome gains/losses contribute to #oncogenesis?
Susanne Lens and collaborators at UMC Utrecht describe a #kinesin-based strategy for inducing #mitotic #missegregation of selected #chromosomes, as tool for modeling specific #aneuploidies -
How do #yeast cells adapt to high rates of #chromosome #missegregation?
Chris Campbell and coworkers @maxperutzlabs define serial alterations from specific #aneuploidies, #karyotype refinement, point #mutations, to loss of beneficial copy number alterations