#lipidtime — Public Fediverse posts

(Glyco-)sphingolipids play important roles in bacterial infections. Studying them requires powerful chemical tools.

Jürgen Seibel talked at #Biochemistry2026 about the synthesis of probes based on (glyco-)sphingolipids and their use to study biology e.g. using expansion microscopy.

https://www.nature.com/articles/s41467-024-51874-w
#Biochemistry #Chemistry #LipidTime #GlycoTime #probes #infections

(Glyco-)sphingolipids play important roles in bacterial infections. Studying them requires powerful chemical tools.

Jürgen Seibel talked at #Biochemistry2026 about the synthesis of probes based on (glyco-)sphingolipids and their use to study biology e.g. using expansion microscopy.

https://www.nature.com/articles/s41467-024-51874-w
#Biochemistry #Chemistry #LipidTime #GlycoTime #probes #infections

(Glyco-)sphingolipids play important roles in bacterial infections. Studying them requires powerful chemical tools.

Jürgen Seibel talked at #Biochemistry2026 about the synthesis of probes based on (glyco-)sphingolipids and their use to study biology e.g. using expansion microscopy.

https://www.nature.com/articles/s41467-024-51874-w
#Biochemistry #Chemistry #LipidTime #GlycoTime #probes #infections

(Glyco-)sphingolipids play important roles in bacterial infections. Studying them requires powerful chemical tools.

Jürgen Seibel talked at #Biochemistry2026 about the synthesis of probes based on (glyco-)sphingolipids and their use to study biology e.g. using expansion microscopy.

https://www.nature.com/articles/s41467-024-51874-w
#Biochemistry #Chemistry #LipidTime #GlycoTime #probes #infections

Great talk by Floor Stevens from the group of Mario van der Stelt of our @LED3hub at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

Great talk by Floor Stevens from the group of Mario van der Stelt of our @LED3hub at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

Great talk by Floor Stevens from the group of Mario van der Stelt of our @LED3hub at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

Great talk by Floor Stevens from the group of Mario van der Stelt of our @LED3hub at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

Great talk by Floor Stevens from the group of Mario van der Stelt of our @LED3hub at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime

How did primitive membranes form at the #OriginOfLife and how did they evolve into the cellular envelopes of modern cells?

Exciting talk by Claudia Bonfio about the non-enzymatic formation of phospholipids under conditions that are plausible for early Earth. https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc05362a (1/2)

#Chemistry #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

How did primitive membranes form at the #OriginOfLife and how did they evolve into the cellular envelopes of modern cells?

Exciting talk by Claudia Bonfio about the non-enzymatic formation of phospholipids under conditions that are plausible for early Earth. https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc05362a (1/2)

#Chemistry #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

How did primitive membranes form at the #OriginOfLife and how did they evolve into the cellular envelopes of modern cells?

Exciting talk by Claudia Bonfio about the non-enzymatic formation of phospholipids under conditions that are plausible for early Earth. https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc05362a (1/2)

#Chemistry #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

How did primitive membranes form at the #OriginOfLife and how did they evolve into the cellular envelopes of modern cells?

Exciting talk by Claudia Bonfio about the non-enzymatic formation of phospholipids under conditions that are plausible for early Earth. https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc05362a (1/2)

#Chemistry #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

How did primitive membranes form at the #OriginOfLife and how did they evolve into the cellular envelopes of modern cells?

Exciting talk by Claudia Bonfio about the non-enzymatic formation of phospholipids under conditions that are plausible for early Earth. https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc05362a (1/2)

#Chemistry #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=80674

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=80674

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=80674

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=80674

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=80674

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=79449

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=79449

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=79449

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=79449

2 Postdoctoral positions in MD simulations of biological membranes @fabiolol

Heidelberg University

#lipidtime You are into membranes & MD simulations? Two postdoc positions: highly collaborative setting @ beautiful Heidelberg - apply now!

See the full job description on jobRxiv: https://jobrxiv.org/job/heidelberg-university-27778-2-postd...
https://jobrxiv.org/job/heidelberg-university-27778-2-postdoctoral-positions-in-md-simulations-of-biological-membranes/?feed_id=79449

🚨Lipid Time🚨

Check our recent review! We delve into the role of Phosphoinositides, highlighting their function as molecular switches 🔛 across various biological processes and how their misregulation causes disease development!

@uniheidelberg
@HelsinkiUni
@freieuniversitaet

#lipidtime
#TRR186

https://www.jbc.org/article/S0021-9258(24)00133-9/fulltext#%20

🚨Lipid Time🚨

Check our recent review! We delve into the role of Phosphoinositides, highlighting their function as molecular switches 🔛 across various biological processes and how their misregulation causes disease development!

@uniheidelberg
@HelsinkiUni
@freieuniversitaet

#lipidtime
#TRR186

https://www.jbc.org/article/S0021-9258(24)00133-9/fulltext#%20

🚨Lipid Time🚨

Check our recent review! We delve into the role of Phosphoinositides, highlighting their function as molecular switches 🔛 across various biological processes and how their misregulation causes disease development!

@uniheidelberg
@HelsinkiUni
@freieuniversitaet

#lipidtime
#TRR186

https://www.jbc.org/article/S0021-9258(24)00133-9/fulltext#%20

🚨Lipid Time🚨

Check our recent review! We delve into the role of Phosphoinositides, highlighting their function as molecular switches 🔛 across various biological processes and how their misregulation causes disease development!

@uniheidelberg
@HelsinkiUni
@freieuniversitaet

#lipidtime
#TRR186

https://www.jbc.org/article/S0021-9258(24)00133-9/fulltext#%20

🚨Lipid Time🚨

Check our recent review! We delve into the role of Phosphoinositides, highlighting their function as molecular switches 🔛 across various biological processes and how their misregulation causes disease development!

@uniheidelberg
@HelsinkiUni
@freieuniversitaet

#lipidtime
#TRR186

https://www.jbc.org/article/S0021-9258(24)00133-9/fulltext#%20

Glycans are sweet,
Nucleic acids—they’re fine.
Proteins are interesting,
But nothing beats #lipidtime!

#ValentinesDay #badpoetry

Glycans are sweet,
Nucleic acids—they’re fine.
Proteins are interesting,
But nothing beats #lipidtime!

#ValentinesDay #badpoetry

Glycans are sweet,
Nucleic acids—they’re fine.
Proteins are interesting,
But nothing beats #lipidtime!

#ValentinesDay #badpoetry

🚨New manuscript: interorganelle lipid transport is rapid, & it is hard to quantify discrete steps in this network, mediated by lipid transfer proteins working at membrane contact sites between different organelles. We (Dongjun Liang & Lin Luan) harness chemoenzymatic tagging & super-fast #bioorthogonal chemistry to make fluorescent lipids that report on PM-to-ER phospholipid flux mediated by a family of lipid transfer proteins at these contact sites! https://doi.org/10.1101/2023.02.01.526230 #lipidtime #chembio

🚨New manuscript: interorganelle lipid transport is rapid, & it is hard to quantify discrete steps in this network, mediated by lipid transfer proteins working at membrane contact sites between different organelles. We (Dongjun Liang & Lin Luan) harness chemoenzymatic tagging & super-fast #bioorthogonal chemistry to make fluorescent lipids that report on PM-to-ER phospholipid flux mediated by a family of lipid transfer proteins at these contact sites! https://doi.org/10.1101/2023.02.01.526230 #lipidtime #chembio

🚨New manuscript: interorganelle lipid transport is rapid, & it is hard to quantify discrete steps in this network, mediated by lipid transfer proteins working at membrane contact sites between different organelles. We (Dongjun Liang & Lin Luan) harness chemoenzymatic tagging & super-fast #bioorthogonal chemistry to make fluorescent lipids that report on PM-to-ER phospholipid flux mediated by a family of lipid transfer proteins at these contact sites! https://doi.org/10.1101/2023.02.01.526230 #lipidtime #chembio

🚨New manuscript: interorganelle lipid transport is rapid, & it is hard to quantify discrete steps in this network, mediated by lipid transfer proteins working at membrane contact sites between different organelles. We (Dongjun Liang & Lin Luan) harness chemoenzymatic tagging & super-fast #bioorthogonal chemistry to make fluorescent lipids that report on PM-to-ER phospholipid flux mediated by a family of lipid transfer proteins at these contact sites! https://doi.org/10.1101/2023.02.01.526230 #lipidtime #chembio

Two surprising take-homes from this work:
1) influenza fusion rates are uncorrelated with target membrane size (and starting curvature)

2) BMP lipids that are enriched in endosomes do affect the efficiency of influenza fusion at the pore formation stage. Previously these lipids had been identified as being important for other viruses but not influenza. Our new assay helps us uncover this dependence. Endosomal lipids are important!

#lipidtime #influenza #viralentry

Thrilled to share this story in JACS Au! https://pubs.acs.org/doi/10.1021/jacsau.2c00419

Takeaways:
1) analogs of PC lipids w/different choline structures adopt different organelle localizations & are useful for tracing interorganelle lipid transport
2) OCT1, a liver transporter typically used to study PK/drug efflux, can also facilitate uptake of small cationic #ChemicalBiology probes, including #bioorthogonal choline analogs. Available soon @Addgene https://addgene.org/188995/

Congrats, Dylan!
#lipidtime #OpenAccess

Thrilled to share this story in JACS Au! https://pubs.acs.org/doi/10.1021/jacsau.2c00419

Takeaways:
1) analogs of PC lipids w/different choline structures adopt different organelle localizations & are useful for tracing interorganelle lipid transport
2) OCT1, a liver transporter typically used to study PK/drug efflux, can also facilitate uptake of small cationic #ChemicalBiology probes, including #bioorthogonal choline analogs. Available soon @Addgene https://addgene.org/188995/

Congrats, Dylan!
#lipidtime #OpenAccess

Thrilled to share this story in JACS Au! https://pubs.acs.org/doi/10.1021/jacsau.2c00419

Takeaways:
1) analogs of PC lipids w/different choline structures adopt different organelle localizations & are useful for tracing interorganelle lipid transport
2) OCT1, a liver transporter typically used to study PK/drug efflux, can also facilitate uptake of small cationic #ChemicalBiology probes, including #bioorthogonal choline analogs. Available soon @Addgene https://addgene.org/188995/

Congrats, Dylan!
#lipidtime #OpenAccess

Thrilled to share this story in JACS Au! https://pubs.acs.org/doi/10.1021/jacsau.2c00419

Takeaways:
1) analogs of PC lipids w/different choline structures adopt different organelle localizations & are useful for tracing interorganelle lipid transport
2) OCT1, a liver transporter typically used to study PK/drug efflux, can also facilitate uptake of small cationic #ChemicalBiology probes, including #bioorthogonal choline analogs. Available soon @Addgene https://addgene.org/188995/

Congrats, Dylan!
#lipidtime #OpenAccess

Here is another one 👉 Beyond PI3Ks: targeting phosphoinositide kinases in disease @NatRevDrugDisc

▶️ Lots of useful info on phosphoinositide kinase inhibitors, for once not focussed on PI3Ks #lipidtime

https://www.nature.com/articles/s41573-022-00582-5

Here is another one 👉 Beyond PI3Ks: targeting phosphoinositide kinases in disease @NatRevDrugDisc

▶️ Lots of useful info on phosphoinositide kinase inhibitors, for once not focussed on PI3Ks #lipidtime

https://www.nature.com/articles/s41573-022-00582-5

I am always super excited by the work of Gerry Hammond, here is his newest review: PI(4,5)P2: signaling the plasma membrane

▶️ BONUS! a super nice timeline of the important milestones in the PI(4,5)P2 field. #lipidtime

https://portlandpress.com/biochemj/article/479/21/2311/232084/PI-4-5-P2-signaling-the-plasma-membrane

I am always super excited by the work of Gerry Hammond, here is his newest review: PI(4,5)P2: signaling the plasma membrane

▶️ BONUS! a super nice timeline of the important milestones in the PI(4,5)P2 field. #lipidtime

https://portlandpress.com/biochemj/article/479/21/2311/232084/PI-4-5-P2-signaling-the-plasma-membrane

Lipid-mediated activation of plasma membrane-localized deubiquitylating enzymes modulate endosomal trafficking @NatureComms #lipidtime #trafficking

▶️ Anionic lipids localize and activate a DUB enzyme at the plant plasma membrane

https://www.nature.com/articles/s41467-022-34637-3

Lipid-mediated activation of plasma membrane-localized deubiquitylating enzymes modulate endosomal trafficking @NatureComms #lipidtime #trafficking

▶️ Anionic lipids localize and activate a DUB enzyme at the plant plasma membrane

https://www.nature.com/articles/s41467-022-34637-3

Hi everyone! I'm @basktastic on Twitter but am trying out my real name here. My #chembio #cellbio #lipidtime lab at Cornell develops tools for imaging and editing the lipidome, drawing on #bioorthogonal chemistry, #clickchemistry, #chemoproteomics, #optogenetics, #directedevolution, and more. https://baskin.wicmb.cornell.edu

Hi everyone! I'm @basktastic on Twitter but am trying out my real name here. My #chembio #cellbio #lipidtime lab at Cornell develops tools for imaging and editing the lipidome, drawing on #bioorthogonal chemistry, #clickchemistry, #chemoproteomics, #optogenetics, #directedevolution, and more. https://baskin.wicmb.cornell.edu

Hi everyone! I'm @basktastic on Twitter but am trying out my real name here. My #chembio #cellbio #lipidtime lab at Cornell develops tools for imaging and editing the lipidome, drawing on #bioorthogonal chemistry, #clickchemistry, #chemoproteomics, #optogenetics, #directedevolution, and more. https://baskin.wicmb.cornell.edu