#histone — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #histone, aggregated by home.social.
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What is the role of active #transcription mark H3K4me3 in #rDNA gene regulation? @shwetatyagicdfd &co show that #histone methyltransferase KMT2F promotes preinitiation complex formation & transcriptional activation of rDNA genes by RNA polymerase I @PLOSBiology https://plos.io/48MSRwh
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What is the role of active #transcription mark H3K4me3 in #rDNA gene regulation? @shwetatyagicdfd &co show that #histone methyltransferase KMT2F promotes preinitiation complex formation & transcriptional activation of rDNA genes by RNA polymerase I @PLOSBiology https://plos.io/48MSRwh
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What is the role of active #transcription mark H3K4me3 in #rDNA gene regulation? @shwetatyagicdfd &co show that #histone methyltransferase KMT2F promotes preinitiation complex formation & transcriptional activation of rDNA genes by RNA polymerase I @PLOSBiology https://plos.io/48MSRwh
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What is the role of active #transcription mark H3K4me3 in #rDNA gene regulation? @shwetatyagicdfd &co show that #histone methyltransferase KMT2F promotes preinitiation complex formation & transcriptional activation of rDNA genes by RNA polymerase I @PLOSBiology https://plos.io/48MSRwh
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What is the role of active #transcription mark H3K4me3 in #rDNA gene regulation? @shwetatyagicdfd &co show that #histone methyltransferase KMT2F promotes preinitiation complex formation & transcriptional activation of rDNA genes by RNA polymerase I @PLOSBiology https://plos.io/48MSRwh
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`Here, we show that the nascent polypeptide-associated complex controls the cotranslational modification of histones H2A and H4 by recruiting NatD and the upstream enzyme MetAP1 to ribosomes. MetAP1 and NatD cooperate on the ribosome to create a confined environment for the efficient sequential modification of the nascent histone chain.`
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`Here, we show that the nascent polypeptide-associated complex controls the cotranslational modification of histones H2A and H4 by recruiting NatD and the upstream enzyme MetAP1 to ribosomes. MetAP1 and NatD cooperate on the ribosome to create a confined environment for the efficient sequential modification of the nascent histone chain.`
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`Here, we show that the nascent polypeptide-associated complex controls the cotranslational modification of histones H2A and H4 by recruiting NatD and the upstream enzyme MetAP1 to ribosomes. MetAP1 and NatD cooperate on the ribosome to create a confined environment for the efficient sequential modification of the nascent histone chain.`
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`Here, we show that the nascent polypeptide-associated complex controls the cotranslational modification of histones H2A and H4 by recruiting NatD and the upstream enzyme MetAP1 to ribosomes. MetAP1 and NatD cooperate on the ribosome to create a confined environment for the efficient sequential modification of the nascent histone chain.`
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`Here, we show that the nascent polypeptide-associated complex controls the cotranslational modification of histones H2A and H4 by recruiting NatD and the upstream enzyme MetAP1 to ribosomes. MetAP1 and NatD cooperate on the ribosome to create a confined environment for the efficient sequential modification of the nascent histone chain.`
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How is the H2A.Z #histone variant targeted to specific sites in the genome by the SWR #chromatin remodeler? This study shows that DNA sequences contribute to SWR specificity and that SWR’s H2A.Z insertion activity is stimulated by polyA tracts in #nucleosomes @PLOSBiology https://plos.io/4kggWyD
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How is the H2A.Z #histone variant targeted to specific sites in the genome by the SWR #chromatin remodeler? This study shows that DNA sequences contribute to SWR specificity and that SWR’s H2A.Z insertion activity is stimulated by polyA tracts in #nucleosomes @PLOSBiology https://plos.io/4kggWyD
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How is the H2A.Z #histone variant targeted to specific sites in the genome by the SWR #chromatin remodeler? This study shows that DNA sequences contribute to SWR specificity and that SWR’s H2A.Z insertion activity is stimulated by polyA tracts in #nucleosomes @PLOSBiology https://plos.io/4kggWyD
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How is the H2A.Z #histone variant targeted to specific sites in the genome by the SWR #chromatin remodeler? This study shows that DNA sequences contribute to SWR specificity and that SWR’s H2A.Z insertion activity is stimulated by polyA tracts in #nucleosomes @PLOSBiology https://plos.io/4kggWyD
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How is the H2A.Z #histone variant targeted to specific sites in the genome by the SWR #chromatin remodeler? This study shows that DNA sequences contribute to SWR specificity and that SWR’s H2A.Z insertion activity is stimulated by polyA tracts in #nucleosomes @PLOSBiology https://plos.io/4kggWyD
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Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD
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Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD
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Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD
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Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD
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Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD
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Why are animals like #NakedMoleRat (NMR) so resistant to #hypoxia & #cancer? This study shows that embryonic fibroblasts from NMRs overexpress #histone 1.2, reducing #tumor formation via the NRF2/P62 pathway & improving resistance to hypoxia #PLOSBiology https://plos.io/4fYjAbd
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Why are animals like #NakedMoleRat (NMR) so resistant to #hypoxia & #cancer? This study shows that embryonic fibroblasts from NMRs overexpress #histone 1.2, reducing #tumor formation via the NRF2/P62 pathway & improving resistance to hypoxia #PLOSBiology https://plos.io/4fYjAbd
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Why are animals like #NakedMoleRat (NMR) so resistant to #hypoxia & #cancer? This study shows that embryonic fibroblasts from NMRs overexpress #histone 1.2, reducing #tumor formation via the NRF2/P62 pathway & improving resistance to hypoxia #PLOSBiology https://plos.io/4fYjAbd
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Why are animals like #NakedMoleRat (NMR) so resistant to #hypoxia & #cancer? This study shows that embryonic fibroblasts from NMRs overexpress #histone 1.2, reducing #tumor formation via the NRF2/P62 pathway & improving resistance to hypoxia #PLOSBiology https://plos.io/4fYjAbd
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Why are animals like #NakedMoleRat (NMR) so resistant to #hypoxia & #cancer? This study shows that embryonic fibroblasts from NMRs overexpress #histone 1.2, reducing #tumor formation via the NRF2/P62 pathway & improving resistance to hypoxia #PLOSBiology https://plos.io/4fYjAbd
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btw, replies with your favorite #histone question are most welcome too :) I have so many more, and looking for some distraction from writing project reports
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btw, replies with your favorite #histone question are most welcome too :) I have so many more, and looking for some distraction from writing project reports
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btw, replies with your favorite #histone question are most welcome too :) I have so many more, and looking for some distraction from writing project reports
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btw, replies with your favorite #histone question are most welcome too :) I have so many more, and looking for some distraction from writing project reports
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btw, replies with your favorite #histone question are most welcome too :) I have so many more, and looking for some distraction from writing project reports
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dear #biology friends... I want to learn more about this:
"#Histone H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."
Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?
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dear #biology friends... I want to learn more about this:
"#Histone H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."
Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?
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dear #biology friends... I want to learn more about this:
"#Histone H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."
Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?
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dear #biology friends... I want to learn more about this:
"#Histone H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."
Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?
-
dear #biology friends... I want to learn more about this:
"#Histone H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."
Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?
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"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"
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"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"
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"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"
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"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"
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"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"
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Histone Serotonylation is one of the crazier epigenetic modifications - #Serotonin, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails.
This happens not only in the brain, but apparently also in the placenta, this new paper shows:
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Chan et al., J Mol B 2024
https://doi.org/10.1016/j.jmb.2024.168454 -
Histone Serotonylation is one of the crazier epigenetic modifications - #Serotonin, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails.
This happens not only in the brain, but apparently also in the placenta, this new paper shows:
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Chan et al., J Mol B 2024
https://doi.org/10.1016/j.jmb.2024.168454 -
Histone Serotonylation is one of the crazier epigenetic modifications - #Serotonin, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails.
This happens not only in the brain, but apparently also in the placenta, this new paper shows:
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Chan et al., J Mol B 2024
https://doi.org/10.1016/j.jmb.2024.168454 -
Histone Serotonylation is one of the crazier epigenetic modifications - #Serotonin, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails.
This happens not only in the brain, but apparently also in the placenta, this new paper shows:
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Chan et al., J Mol B 2024
https://doi.org/10.1016/j.jmb.2024.168454 -
Histone Serotonylation is one of the crazier epigenetic modifications - #Serotonin, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails.
This happens not only in the brain, but apparently also in the placenta, this new paper shows:
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Chan et al., J Mol B 2024
https://doi.org/10.1016/j.jmb.2024.168454
