#metformin — Public Fediverse posts

Metformin, the diabetes drug that has been thought to suppress glucose production in the liver, instead inhibits mitochondria in the gut, causing the gut to increase its consumption (and breakdown) of glucose.

Summary: https://refractor.io/diabetes/metformin-gut-health-benefits/

Original paper: https://www.nature.com/articles/s42255-026-01530-y

#Science #Metformin #Diabetes #Metabolism

Metformin targets the gut instead of the liver to lower glucose

For decades, physicians and scientists thought metformin, the leading Type 2 diabetes medication taken by millions worldwide, mainly…
#NewsBeep #News #Science #biochemistry #Blood #bloodsugar #CA #Canada #Cell #Citrulline #diabetes #Enzyme #Genetics #Glucose #Insulin #InsulinResistance #Liver #medicine #Metabolism #metformin #Mitochondria #supplements #Type2Diabetes
https://www.newsbeep.com/ca/655947/

https://www.europesays.com/ie/474741/ Metformin targets the gut instead of the liver to lower glucose #Biochemistry #blood #BloodSugar #Cell #Citrulline #diabetes #Éire #Enzyme #Genetics #Glucose #IE #Insulin #InsulinResistance #Ireland #Liver #medicine #Metabolism #Metformin #Mitochondria #Science #supplements #Type2Diabetes

https://www.europesays.com/at/139853/ Fatigue trifft Blutzucker: Wie ME/CFS und Diabetes zusammenhängen #AID #AT #Austria #AutonomesNervensystem #BrainFog #CGM #ChronischesFatigueSyndrom #DDG #DiabetesMellitus #Diabetesberatung #Gesundheit #GLP1Rezeptoragonisten #Health #Hypoglykämie #Insulinresistenz #Komorbidität #LongCOVID #ME/CFS #Metformin #Österreich #Pacing #PostCOVID #PostExertionelleMalaise #VDBD

https://www.europesays.com/at/101330/ Metformin als potenzieller Ersatz für Bewegung bei Prostatakrebs #AT #Austria #Gesundheit #Health #Hormontherapie #LacPhe #Metformin #Österreich #Prostatakrebs #Stoffwechsel

Metformin Raises Exercise-Associated Metabolite Lac-Phe in Prostate Cancer Patients on Hormone Therapy

📰 Original title: Diabetes Drug, Metformin, May Echo the Benefits of Exercise in Prostate Cancer Care

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

View full AI summary: https://killbait.com/en/metformin-raises-exercise-associated-metabolite-lac-phe-in-prostate-cancer-patients-on-hormone-therapy/?redirpost=e646279c-9669-4f2b-83ba-fba5b2643fac

#health #metformin #prostate...

After 60+ years, the common diabetes drug metformin has been found to unexpectedly affect the brain.
A new study shows it targets the protein Rap1 in the ventromedial hypothalamus, activating SF1 neurons to help lower blood glucose — and it works at much lower concentrations in the brain than in the body.
Promising findings that could lead to better treatments for glucose control and possibly brain protection.

#Metformin #Diabetes #BrainHealth #MedicalResearch #Prediabetes

https://www.sciencealert.com/after-60-years-diabetes-drug-revealed-to-unexpectedly-affect-the-brain

THREAT MODEL: COVID 🦠
for Mar. 12th, 2026
by independent journalist @violetblue

- #USmilitary study concludes 42% of #Covid infections lead to #LongCovid "regardless of initial disease severity”

- RFK’s #MAHA Institute calls to eliminate all childhood vaccines

- A new Long Covid treatment guide

- Babies with Covid “develop more serious disease than those with RSV”

- Trump admin removes more Covid datasets

- #Aotearoa #NewZealand ’s new Covid report smothered by disinformation

- #AotearoaNZ vaccinologist: repeat infection is “accumulating damage”

- Study: #Metformin reduces Long Covid risk but not an effective LC treatment

- US survey: only 26 of 400 Long Covid clinics remain

...and much more.

✨THREAT MODEL is free to read -- please help keep it accessible to all by becoming a patron, even $1 a month makes a difference!✨

https://www.patreon.com/posts/covid-march-12-152830056

#ThreatModel #ThreatModelCovid #ThreatModelNewsletters #VioletBlue #COVIDnews #PublicHealth #CovidIsNotOver

https://www.europesays.com/at/26617/ Forscher entdecken neue Schwachstelle bei therapieresistentem Brustkrebs #AT #Austria #CellDeath&Disease #Dichloracetat #DrNiklasGremke #Gesundheit #Health #LuiseVonWichert #Metformin #Österreich

𝙏𝙝𝙧𝙚𝙖𝙩 𝙈𝙤𝙙𝙚𝙡: 𝘾𝙤𝙫𝙞𝙙
𝘧𝘰𝘳 Feb. 5th, 2026
𝘣𝘺 𝘫𝘰𝘶𝘳𝘯𝘢𝘭𝘪𝘴𝘵 @violetblue

- Trends suggest US is in for a second #Covid surge

- First vaccine targeting #SARS virus family enters human trials

- Even more evidence showing #metformin prevents #LongCovid

- Australian #WinterOlympics team staff test positive for Covid ahead of #WinterOlympics2026 Milano Cortina Games

- Four #EU orgs form international federation Long COVID Rise Up

- Largest pediatric Long Covid trial to launch this year

- Many older US adults haven’t had recent flu or Covid vaccine

- Large study finds Covid shots don’t affect fertility (but catching Covid does)

- New study: Covid in pregnancy linked w/risk of childhood neurodevelopmental disorders

...and much more.

* 𝙏𝙝𝙧𝙚𝙖𝙩 𝙈𝙤𝙙𝙚𝙡 𝘪𝘴 𝘧𝘳𝘦𝘦 𝘵𝘰 𝘳𝘦𝘢𝘥 -- 𝘱𝘭𝘦𝘢𝘴𝘦 𝘩𝘦𝘭𝘱 𝘬𝘦𝘦𝘱 𝘪𝘵 𝘢𝘤𝘤𝘦𝘴𝘴𝘪𝘣𝘭𝘦 𝘵𝘰 𝘢𝘭𝘭 𝘣𝘺 𝘣𝘦𝘤𝘰𝘮𝘪𝘯𝘨 𝘢 𝘱𝘢𝘵𝘳𝘰𝘯, 𝘦𝘷𝘦𝘯 $1/𝘮𝘰𝘯𝘵𝘩 𝘮𝘢𝘬𝘦𝘴 𝘢 𝘥𝘪𝘧𝘧𝘦𝘳𝘦𝘯𝘤𝘦 *

https://www.patreon.com/posts/covid-february-5-149973355

#ThreatModel #ThreatModelCovid #ThreatModelNewsletters #VioletBlue #COVIDnews #PublicHealth #CovidIsNotOver

A common diabetes drug may prevent long COVID when taken early

Large clinical trials and real-world data point to a familiar diabetes drug as a simple, safe way to…
#NewsBeep #News #Health #AU #Australia #chestpain #coronavirus #covid-19 #diabetes #Efficacy #Fatigue #Healthcare #infectiousdiseases #Laboratory #medicine #metformin #Pain #pandemic #Placebo #Respiratory #SARS #SARS-CoV-2 #SevereAcuteRespiratory #SevereAcuteRespiratorySyndrome #Syndrome #virus
https://www.newsbeep.com/au/455705/

@unchartedworlds @EricCarroll No, that's right, and it is super cheap.

It's really interesting that #metformin seems to have antiviral effects, given the reduction in viral load reported there. I wonder what other viruses it effects similarly?

#covid #LongCovid

https://www.europesays.com/ie/228642/ Scientists outline how organ rejuvenation strategies could solve the donor shortage #Aging #AntiInflammatory #Antioxidant #blood #Cell #CellDeath #Cytokine #DNA #Drugs #Edema #Éire #fibrosis #Genes #Health #IE #inflammation #Ion #Ireland #Liver #Lungs #Metabolism #Metformin #Mitochondria #Nutrients #Organelle #OxidativeStress #Oxygen #pH #Preclinical #Stress #Transplant #Vascular

#LabPlot at the service of #researchers. :boost_love:

@[email protected]

It's rewarding to us to know that #LabPlot was used for the #drug release #kinetics investigation in this recent study on niosomal co-delivery of #metformin and #telaglenastat.

➡️ https://www.sciencedirect.com/science/article/pii/S0753332225010376

#Research #Science #OpenSource #FreeSoftware #FOSS #KDE #FreeOriginProAlternative #BreastCancer #Cancer #Cytotoxicity

Last week, I had another check-up by our company physician.(*)

The _last_ one, three years ago, ended very dramatically - the physician called me the next day and told me that my blood sugar values were so high that I should check in with a clinic _right now_.

I did so, stayed there for two nights(**), got some #insulin injections, got out, had a few further medical checkups, and took #metformin for a year.

I also had a few appointments with a nutritionist who explained a few things to me. I then made a few changes to my diet and my exercise habits.

After that year had passed, my blood sugar levels were low enough that my #diabetes could be considered in full remission, and I stopped taking the pills - although I still check my blood sugar values regularly.

I didn't get my full evaluation yet. However, I did learn that my eyesight is a lot better than three years ago - back then, I was told that I shouldn't drive without glasses (which was easy to do, since I don't drive cars anyway). Now I have full vision again at both long and intermediate ranges, although I need reading glasses on short distances (which I already knew).

So while it's not always possible to control all aspects of one's health, I _am_ pretty glad I managed to control _this_ one.

(*) For the record, I live in a country where it is illegal for my employer to know any medical details about me other than the minimum necessary - such as "This person is sick, and cannot come to work this week". So while this physician was hired by our company to do these (voluntary) checkups, he does maintain patient confidentiality.

(**) Total out-of-pocket costs: €30, plus another €15 for WLAN access.

#Gesundheit #Langlebigkeit
#Diabetes

*Gängiges Medikament könnte Lebenserwartung von Frauen erhöhen*

(2/2)

👉Das Medikament kann verschiedene #Alterungsprozesse im Körper verlangsamen. Studien bescheinigen ihm etwa, #DNA-Schäden zu reduzieren oder Gene zu aktivieren, die mit #Langlebigkeit in Verbindung stehen. Frühere Arbeiten deuteten auch darauf hin, dass #Metformin den altersbedingten Abbau des #Gehirns verlangsamen und sogar das Risiko für #LongCovid senken könnte... 👈"

//

@de

#Gesundheit #Langlebigkeit
#Diabetes

*Gängiges Medikament könnte Lebenserwartung von Frauen erhöhen*

(1/2)

"Trotz einiger Einschränkungen der Studie zeigte die Auswertung: 👉Frauen, die #Metformin erhielten, hatten ein rund 30 Prozent geringeres Risiko, vor ihrem 90. Geburtstag zu sterben👈 als jene, die mit einem anderen #Diabetesmittel behandelt wurden."

"Metformin ist seit Jahrzehnten auf dem Markt und gilt als #Gerotherapeutikum...

https://www.europesays.com/de/597383/

@de

RE: https://mastodon.social/@ScienceScholar/115601989659657758

Don't let the dire-sounding headline confuse you. This all sounds like good news (I've been taking the stuff for about at least eight years now). The stuff still works, and the possible side effects discussed are GOOD and make more sense now.

#diabetes #medicine #medications #metformin

A double-blind clinical trial of the effect of metformin on exercise response, in 72 adults at risk for diabetes and heart disease, confirmed that metformin counters the beneficial effects of exercise, possibly though its action of blocking mitochondrial activity.

Summary: https://scienceblog.com/when-exercise-stops-working-how-metformin-blocks-the-bodys-gains/

Original paper (not open access): https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaf551/8276136?redirectedFrom=fulltext

#Science #Health #Diabetes #CVD #Exercise #Metformin

Metformin reduces risk of Long Covid. https://thesicktimes.org/2025/10/28/metformin-has-been-shown-to-reduce-the-risk-of-long-covid-why-isnt-it-more-widely-used/?mc_cid=01de0f1b88&mc_eid=4b751fcf19

#TheSickTimes #LongCovid #ProlongedPandemic #pandemic #disease #illness #sick #chronic #MedMastodon #medicine #medical #Metformin #Rapamycin #diagnose #prognosis #wellness #digestion #diabetes #hba1c #doctor #doctors #clinic #GP #physicians

#metformin

"After 60 Years, Diabetes Drug Found to Unexpectedly Impact The Brain

Metformin has been prescribed to people with type 2 diabetes to manage blood sugar for more than 60 years, but scientists haven't been exactly sure how it works. A new study suggests it works directly in the brain, which could lead to new types of treatment."

https://www.sciencealert.com/after-60-years-diabetes-drug-found-to-unexpectedly-impact-the-brain

A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00229

lots of details on #pathophysiology in this review

#MECFS #LongCovid #metformin #DrugRepurposing #medicine #health
#WASF3

Neue Studie aus Großbritannien zeigt, dass #Metformin bei #Corona-Risikopatient:innen mit Übergewicht das #LongCovid-Risiko deutlich reduzieren kann:
https://www.news-medical.net/news/20250908/Common-diabetes-drug-metformin-cuts-long-covid-risk-by-64-percent-in-UK-study.aspx

#Evidence that #metformin is not effective against #COVID19. #Covid #Corona

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2836528

After 60 Years, #Scientists Uncover Hidden #Brain Pathway Behind #Diabetes Drug #Metformin

https://scitechdaily.com/after-60-years-scientists-uncover-hidden-brain-pathway-behind-diabetes-drug-metformin/

Another paper about AMPK. This gives a good overview as well as information about AMPK activation.

Takeaway: If you wish you had access to Metformin but don't, you might want to look into what this paper says about AMPK activation.

https://pmc.ncbi.nlm.nih.gov/articles/PMC4039279/

#AMPK #Metformin

#AMPK #Longevity #PublicHealth

Seit 15 Jahren wird mein #diabetestype2 mit einem Kombipräparat aus #Metformin behandelt und lag immer beim #hba1c um die 6%. Durch die Sportabstinenz des letzten halben Jahres ist er auf 8,5 % geklettert. Mein Hausarzt hat mir daher zusätzlich "Jardiance", einen SGLT2-Hemmer verordnet, den ich nun seit 14 Tagen nehme. Neben einem #Gewichtsverlust von aktuell 2,3 kg ist auch mein Blutdruck deutlich nach unten gegangen.
Nimmt hier auch jemand dieses Mittel und hat evtl. Langzeiterfahrung?

Anti-ageing drug rapamycin may extend life almost as effectively as restricting calories – our new research
#Health #Rapamycin #AntiAgeing #Longevity #DietMimics #CalorieRestriction #LifeExtension #AgeingResearch #Metformin #HealthSpan #ScientificResearch
https://the-14.com/anti-ageing-drug-rapamycin-may-extend-life-almost-as-effectively-as-restricting-calories-our-new-research/

Anti-ageing drug rapamycin may extend life almost as effectively as restricting calories – our new research
#Health #Rapamycin #AntiAgeing #Longevity #DietMimics #CalorieRestriction #LifeExtension #AgeingResearch #Metformin #HealthSpan #ScientificResearch
https://the-14.com/anti-ageing-drug-rapamycin-may-extend-life-almost-as-effectively-as-restricting-calories-our-new-research/

Es wurden folgende Wirkstoffe von der "Expertengruppe Long COVID Off-Label-Use" positiv bewertet:
- Agomelatin
- Ivabradin
- Naltrexon (Low Dose)
- Vortioxetin
- Metformin

Das Ergebnisprotokoll der 11. Sitzung der Expertengruppe am 02.04.2025 kann hier eingesehen werden: https://www.bfarm.de/DE/Arzneimittel/Zulassung/Zulassungsrelevante-Themen/Expertengruppe-Long-COVID-Off-Label-Use/Protokolle/EP_11-Sitzung_02-04-2025.html?nn=1628850

#OffLabelUse #MECFS #LongCovid #OffLabel #Expertengruppe #BfArM #Therapie #LDN #Metformin #Vortioxetin #Agomelatin #Ivabradin
2/2

“Loomans-Kropp is especially excited about the drug's potential in treating a common type of colon cancer caused by a mutated KRAS gene, which tends to be very tough to treat.” #dna #isogg #epigenetics #coloncancer #metformin #KRAS

https://www.businessinsider.com/metformin-being-studied-colon-cancer-stopping-supplement-2025-5

4.) Is there currently any evidence of efficacy of any of the proposed "#anti-aging drugs" and interventions in human aging? E.g. #rapamycin, #metformin #resveratrol but also #reprogramming, #rejuvenation, #caloric restriction and others? In other words, is there a shortcut to health and eternal life? Spoiler: you might not like the answer... Moreover, some of these might even have negative effects on other health-beneficial interventions, e.g. the potential dampening of exercise training adaptation by metformin, resveratrol or rapamycin.

5.) We discuss all of the known factors for which solid data and proof for an impact on human health, the aging process, #morbidity (risk for a disease), #mortality (risk of premature death) and life expectancy exist. The good news: only around 20% (or even as low as 10%) of our aging trajectory is determined by our genes – this means that to a large majority, we can influence this ourselves! Some can be done on the individual level, first and foremost by physical activity, but also #sleep, #nutrition, #stress, social interactions and more. Others will have to be addressed on the societal/political level, e.g. #socioeconomic disparities or access to quality (and affordable) health care. Lastly, there are factors such as anthropogenic #climatechange or #pollution (e.g. air pollution or #microplastics) that we have to solve on a global scale.

2/4

4.) Is there currently any evidence of efficacy of any of the proposed "#anti-aging drugs" and interventions in human aging? E.g. #rapamycin, #metformin #resveratrol but also #reprogramming, #rejuvenation, #caloric restriction and others? In other words, is there a shortcut to health and eternal life? Spoiler: you might not like the answer... Moreover, some of these might even have negative effects on other health-beneficial interventions, e.g. the potential dampening of exercise training adaptation by metformin, resveratrol or rapamycin.

5.) We discuss all of the known factors for which solid data and proof for an impact on human health, the aging process, #morbidity (risk for a disease), #mortality (risk of premature death) and life expectancy exist. The good news: only around 20% (or even as low as 10%) of our aging trajectory is determined by our genes – this means that to a large majority, we can influence this ourselves! Some can be done on the individual level, first and foremost by physical activity, but also #sleep, #nutrition, #stress, social interactions and more. Others will have to be addressed on the societal/political level, e.g. #socioeconomic disparities or access to quality (and affordable) health care. Lastly, there are factors such as anthropogenic #climatechange or #pollution (e.g. air pollution or #microplastics) that we have to solve on a global scale.

2/4

Scientists Pinpoint Cause of Severe Morning Sickness (gift link - no paywall)
https://www.nytimes.com/2023/12/13/health/morning-sickness-hyperemesis-gravidarum.html?unlocked_article_code=1.F00.GEZi.34JQE09jCJmL

Takeaways:
1. Doctors suck at listening to women (not news, but the article confirms it)
2. Those 23andme surveys actually led to a breakthrough (probably not news, but it's the first time I've seen it called out in a news story)
3. Metformin might find an off label use to prevent morning sickness (my speculation, not fact)

#nytimes #healthcare #pregnancy #morningSickness #metformin #GDF15

#diabetes #diabemal eine Frage an die Bubble, kennt ihr das Medikament #icandra von #Novatis? Weiss einer warum es nach der Wiederzulassung vor einigen Jahren nun nicht mehr erhältlich ist. #Stada, #1aPharma haben aber ihr Medikament mit #vitaglibtin / #Metformin weiterhin am Markt.

#biohackers #metformin #agelessrx #epigenetics #dna #rapamycin https://www.wsj.com/articles/rapamycin-anti-aging-drug-longevity-a27575f4?reflink=mobilewebshare_permalink