#inactivation — Public Fediverse posts

#Inactivation of #Influenza A Viruses (#H1N1, #H5N1) During #Grana-Type Raw #Milk #Cheesemaking: Implications for Foodborne #Transmission Risk, https://etidiohnew.blogspot.com/2025/06/inactivation-of-influenza-viruses-h1n1.html

Thermal #inactivation #spectrum of #influenza A #H5N1 virus in raw #milk, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.21.614205v1

Efficient inactivation of virus was observed in all tested conditions, except for thermization at 50°C 10 min. Utilizing a submerged coil system with temperature ramp up times that resemble commercial pasteurizers, we showed that the virus was rapidly inactivated by #pasteurization and most thermization conditions.

#Effectiveness of #Pasteurization for #Inactivation of #H5N1 #Influenza Virus in Raw Whole #Milk, MedRxIV: https://www.medrxiv.org/content/10.1101/2024.07.23.24310825v1

Complete inactivation was achieved after incubation of H5N1 spiked raw milk at 63C for 30 min. Complete viral inactivation was observed in 7 out of 8 replicates of raw milk samples treated at 72C for 15 sec. In 1 replicate, a 4.56 log reduction was achieved, which is about 1 log higher than average viral quantities detected in bulk tanks in affected areas.

#Inactivation of highly pathogenic avian #influenza virus with high #temperature short time continuous flow #pasteurization and virus #detection in bulk milk #tanks {Unpublished}, https://www.fda.gov/media/179708/download?attachment

Estimates from heat-transfer analysis support that standard continuous flow HTST pasteurization parameters will inactivate >12 log10 EID50/mL of HPAIV, which is ~9 log10 EID50/mL greater than the mean quantity of infectious virus detected in raw milk from bulk storage tank samples.

[US] #FDA #Research #Agenda for 2024 Highly Pathogenic #H5N1 Avian #Influenza, https://www.fda.gov/media/179559/download?attachment

Investigating #temperature thresholds and #duration required to effectively neutralize #H5N1 HPAI virus is necessary to better understand #inactivation methods. FDA is working on multiple efforts to understand the effectiveness of #pasteurization and other inactivation methods.

#Cow’s #Milk Containing Avian #Influenza A(#H5N1) Virus — #Heat #Inactivation and #Infectivity in Mice, N Engl J Med.: https://www.nejm.org/doi/full/10.1056/NEJMc2405495?query=RP&cid=NEJM%20Recently%20Published,%20May%2024%20(2),%202024%20DM2342123_NEJM_Non_Subscriber&bid=-1978672809

The cow viruses form a single clade encompassing many smaller clades of viruses isolated from cats, raccoons, chickens, and wild birds. The phylogeny is consistent with a single introduction into cows.

#Cow’s #Milk Containing Avian #Influenza A(#H5N1) Virus — #Heat #Inactivation and #Infectivity in Mice, N Engl J Med.: https://www.nejm.org/doi/full/10.1056/NEJMc2405495?query=RP&cid=NEJM%20Recently%20Published,%20May%2024%20(2),%202024%20DM2342123_NEJM_Non_Subscriber&bid=-1978672809

The cow viruses form a single clade encompassing many smaller clades of viruses isolated from cats, raccoons, chickens, and wild birds. The phylogeny is consistent with a single introduction into cows.

#Cow’s #Milk Containing Avian #Influenza A(#H5N1) Virus — #Heat #Inactivation and #Infectivity in Mice, N Engl J Med.: https://www.nejm.org/doi/full/10.1056/NEJMc2405495?query=RP&cid=NEJM%20Recently%20Published,%20May%2024%20(2),%202024%20DM2342123_NEJM_Non_Subscriber&bid=-1978672809

The cow viruses form a single clade encompassing many smaller clades of viruses isolated from cats, raccoons, chickens, and wild birds. The phylogeny is consistent with a single introduction into cows.

#Cow’s #Milk Containing Avian #Influenza A(#H5N1) Virus — #Heat #Inactivation and #Infectivity in Mice, N Engl J Med.: https://www.nejm.org/doi/full/10.1056/NEJMc2405495?query=RP&cid=NEJM%20Recently%20Published,%20May%2024%20(2),%202024%20DM2342123_NEJM_Non_Subscriber&bid=-1978672809

The cow viruses form a single clade encompassing many smaller clades of viruses isolated from cats, raccoons, chickens, and wild birds. The phylogeny is consistent with a single introduction into cows.

#Cow’s #Milk Containing Avian #Influenza A(#H5N1) Virus — #Heat #Inactivation and #Infectivity in Mice, N Engl J Med.: https://www.nejm.org/doi/full/10.1056/NEJMc2405495?query=RP&cid=NEJM%20Recently%20Published,%20May%2024%20(2),%202024%20DM2342123_NEJM_Non_Subscriber&bid=-1978672809

The cow viruses form a single clade encompassing many smaller clades of viruses isolated from cats, raccoons, chickens, and wild birds. The phylogeny is consistent with a single introduction into cows.