#trypanosomes — Public Fediverse posts

#Phosphofructokinase (PFK) is considered an irreversible glycolytic #enzyme. This study shows that #Trypanosomes are the only known organism to use PFK in the gluconeogenic direction under normal conditions, likely due to its compartmentalization within glycosomes @PLOSBiology https://plos.io/43r84Qc

Pam16 & Pam18 are essential for #mitochondrial protein import in eukaryotes, but not in #Trypanosomes. @aschneiderlab show that TbPam16/18 have been repurposed to regulate #replication of #maxicircles within the T. brucei mitochondrial genome #PLOSBiology https://plos.io/3STOEis

Professor Isabel Roditi @unibern has been awarded an @ERC_Research Advanced Grant. @Uni_WUE she will investigate #trypanosomes, the pathogens that cause sleeping sickness. #Tryptaxis #ERCAdG
https://nachrichten.idw-online.de/2024/04/18/erc-advanced-grant-2-5-million-euros-for-isabel-roditi

Professor Isabel Roditi @unibern has been awarded an @ERC_Research Advanced Grant. @Uni_WUE she will investigate #trypanosomes, the pathogens that cause sleeping sickness. #Tryptaxis #ERCAdG
https://nachrichten.idw-online.de/2024/04/18/erc-advanced-grant-2-5-million-euros-for-isabel-roditi

Professor Isabel Roditi @unibern has been awarded an @ERC_Research Advanced Grant. @Uni_WUE she will investigate #trypanosomes, the pathogens that cause sleeping sickness. #Tryptaxis #ERCAdG
https://nachrichten.idw-online.de/2024/04/18/erc-advanced-grant-2-5-million-euros-for-isabel-roditi

Professor Isabel Roditi @unibern has been awarded an @ERC_Research Advanced Grant. @Uni_WUE she will investigate #trypanosomes, the pathogens that cause sleeping sickness. #Tryptaxis #ERCAdG
https://nachrichten.idw-online.de/2024/04/18/erc-advanced-grant-2-5-million-euros-for-isabel-roditi

Professor Isabel Roditi @unibern has been awarded an @ERC_Research Advanced Grant. @Uni_WUE she will investigate #trypanosomes, the pathogens that cause sleeping sickness. #Tryptaxis #ERCAdG
https://nachrichten.idw-online.de/2024/04/18/erc-advanced-grant-2-5-million-euros-for-isabel-roditi

Interested in #mRNA and #trypanosomes? My dear (Tootless) friend Susanne Kramer has a #DFG-funded #PhD position available now in my old home of the University of Würzburg. Full details (including contact email) in the pic below 👇

New preprint from Sam Dean and colleagues introducing molecular tools for tagging in Tryps:

Unlocking Trypanosome Biology: A Comprehensive Protein-Tagging Toolkit for Localization and Functional Analysis

https://www.biorxiv.org/content/10.1101/2023.04.21.537815v1

#CellBiology #MolecularBiology #Trypanosomes

African #trypanosomes mapped for the first time to understand evolution and potential treatments https://phys.org/news/2023-03-african-trypanosomes-evolution-potential-treatments.html

Genome-wide subcellular protein map for the flagellate parasite #Trypanosoma brucei: Karen Billington et al. https://www.nature.com/articles/s41564-022-01295-6 #protists #parasites

For the first time ever, scientists have developed a detailed "protein atlas" of a pathogen—a kind of biological map that locates proteins in cells.

How #Trypanosomes keep their mitochondrial genome https://fems-microbiology.org/femsmicroblog-how-trypanosomes-keep-their-mitochondrial-genome/

Mitochondrial #genome maintenance—the #kinetoplast story: Simona Amodeo et al. https://academic.oup.com/femsre/advance-article/doi/10.1093/femsre/fuac047/6855247

The parasite #Trypanosoma brucei lives and replicates in insect vectors like the fly. During the mating process, both its #nucleus and #mitochondrion replicate and exchange their genetic information, while the mitochondrial mechanism is still incompletely understood.