#trypanosoma — Public Fediverse posts

African #trypanosomes mapped for the first time to understand evolution and potential treatments https://phys.org/news/2023-03-african-trypanosomes-evolution-potential-treatments.html

Genome-wide subcellular protein map for the flagellate parasite #Trypanosoma brucei: Karen Billington et al. https://www.nature.com/articles/s41564-022-01295-6 #protists #parasites

For the first time ever, scientists have developed a detailed "protein atlas" of a pathogen—a kind of biological map that locates proteins in cells.

Now live at eLife: Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins

https://elifesciences.org/articles/85537

The first part of a developing project looking into the enigmatic origins of insect Gustatory and Odorant receptors!

#olfaction #smell #taste #gustation #evolution #molecularevolution #phylogenetics #LECA #trypanosoma #drosophila #AlphaFold

How #Trypanosomes keep their mitochondrial genome https://fems-microbiology.org/femsmicroblog-how-trypanosomes-keep-their-mitochondrial-genome/

Mitochondrial #genome maintenance—the #kinetoplast story: Simona Amodeo et al. https://academic.oup.com/femsre/advance-article/doi/10.1093/femsre/fuac047/6855247

The parasite #Trypanosoma brucei lives and replicates in insect vectors like the fly. During the mating process, both its #nucleus and #mitochondrion replicate and exchange their genetic information, while the mitochondrial mechanism is still incompletely understood.

"It can be between 10 and 30 years before people develop symptoms so most are unaware they have Chagas, often called a “silent and silenced disease”. Some will never develop symptoms but up to a third suffer heart damage, which can lead to progressive heart failure or sudden death. Others (up to 10%) may experience abnormal enlargement of the colon or oesophagus.

About 12,000 people die from Chagas every year. It kills more people in Latin America than any other parasitic disease, including malaria."

#Parasitology #Immunology #PublicHealth #ChagasDisease
#Trypanosoma #Tcruzi

https://www.theguardian.com/global-development/2023/jan/16/the-silent-disease-chagas-is-a-killer-now-carriers-want-their-voices-heard

Our new preprint on the deeply conserved structure, and evolution, of insect Gustatory and Odorant receptors. The plethora of chemosensors in insects may be the result of extreme and rapid diversification of a single branch of a diverse superfamily of Eukaryotic (including human!) receptors, dating to at least LECA. An exceptionally fun collaboration with @[email protected] come to fruition! https://doi.org/10.1101/2022.12.13.519744

#olfaction #taste #evolution #phylogenetics #LECA #trypanosoma #drosophila #AlphaFold

Paper alert🚨!

Intracellular #Trypanosoma cruzi amastigotes retain a short flagellum, which for first time has been obsevced beating within another eukaryotic cell!

#protists #parasites #MicrobialEukaryotes

https://www.biorxiv.org/content/10.1101/2022.11.23.517661v1?rss=1