#integrases — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #integrases, aggregated by home.social.
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"We developed a method of #phage-assisted continuous evolution we call IntePACE..to systematically improve activity of PhiC31 & Bxb1 serine integrases..hyperactive mutants were generated..resulting in integration of a multi-gene cargo at rates as high as 80%..Hyperactive integrases inserted a 15.7 kb therapeutic #DNA cargo..This #technology could accelerate #gene delivery #therapeutics & our directed evolution strategy can easily be adapted to improve novel #integrases"
https://academic.oup.com/nar/article/52/14/e64/7702507?login=false