#hypothalamus — Public Fediverse posts

https://www.europesays.com/fr/784124/ Et si vos nuits révélaient la maladie de Charcot des années avant les symptômes ? #CellulesNerveuses #cerveau #charcot #FR #France #Health #hypothalamus #MaladieDeCharcot #MaladieNeuroDégénérative #Motoneurones #MuscleRespiratoire #neurone #NeuroneàOrexine #Santé #SLA #sommeil #TroubleMoteur #TroublesDuSommeil

https://www.europesays.com/ch-fr/38070/ Et si vos nuits révélaient la maladie de Charcot des années avant les symptômes ? #CellulesNerveuses #cerveau #Charcot #Health #Hypothalamus #MaladieDeCharcot #MaladieNeuroDégénérative #Motoneurones #MuscleRespiratoire #Neurone #NeuroneàOrexine #Santé #SLA #sommeil #Suisse #TroubleMoteur #TroublesDuSommeil

https://www.europesays.com/be-fr/32688/ Et si vos nuits révélaient la maladie de Charcot des années avant les symptômes ? #BE #BEFr #Belgique #Belgium #CellulesNerveuses #Cerveau #charcot #Health #Hypothalamus #MaladieDeCharcot #MaladieNeuroDégénérative #Motoneurones #MuscleRespiratoire #Neurone #NeuroneàOrexine #Santé #SLA #Sommeil #TroubleMoteur #TroublesDuSommeil

🧠 New preprint by Kim et al. (2025) from David Anderson’s lab: A line #attractor maintains aggressiveness during feeding in “hangry” mice 🍔🐁. Using in vivo #CalciumImaging and #rSLDS modeling, they show how moderate fasting stabilizes an aggression-related attractor in #VMHvl, while prolonged fasting collapses it, linking hunger, motivation, and aggression through #PopulationDynamics:

🌍 https://doi.org/10.1101/2025.10.16.682711

#Neuroscience #CompNeuro #Behavior #AttractorDynamics #Hypothalamus #2p #imaging

SciTech Chronicles.. . . . . .May 8th, 2025

https://bit.ly/stc051425

#vertebra #imaging #tegu #oVert #LMR #Maganese #prismatic #lithium-ion #obsessions #compulsions #GWAS #hypothalamus #Bespoke #protein #catalysts #"de novo protein design" #"smart fabric" #comfort #durability

SciTech Chronicles.. . . . . .May 8th, 2025

https://bit.ly/stc051425

#vertebra #imaging #tegu #oVert #LMR #Maganese #prismatic #lithium-ion #obsessions #compulsions #GWAS #hypothalamus #Bespoke #protein #catalysts #"de novo protein design" #"smart fabric" #comfort #durability

Sleep normalizes #synapses in the cortex & hippocampus that have been potentiated during the daytime. This study shows that slow-wave #sleep also down-regulates #AMPAreceptor levels in the #hypothalamus, a brain region that regulates sleep #PLOSBiology https://plos.io/3MdTALe

#Hyperglycemia activates glucose sensing & feeding behavior in #hypothalamus via CSF. @katterineSalaz2 @FranciscoNuala2 &co show that raised CSF glucose induces SCO-spondin & Wnt5a release, controlling ciliary beating in #EpendymalCells. #PLOSBiology https://plos.io/3Rsb8qV

Subset of neurons in #hypothalamus increases appetite & decreases #thermogenesis. @JongSohn &co show that ion channel GIRK2 functions in hypothalamic NPY/AgRP neurons to increase energy expenditure in mice and may control body weight @kaistpr #PLOSBiology https://plos.io/3qGa8Ev

Healing from the hypothalamus –

To survive an infection, our body must recognize and respond to invading pathogens. This is the job of the immune system. When the first few immune cells encounter a pathogen, especially one that they haven’t seen before, they start releasing #cytokines like #interleukin-1 (IL-1).

These cytokines are the messengers of the immune system. They race through the body via the bloodstream, summoning immune troops to push back the invading pathogen.

When they reach the central nervous system, cytokines must cross the #blood-#brain #barrier to alert and recruit a brain response. The blood-brain barrier has only a handful of entry points, called #circumventricular #organs, where traffic can pass between the central nervous system and the bloodstream with relative ease.

One of these sits at the base of the #hypothalamus in a structure called the #Vascular #Organ of the #Lamina #Terminalis (VOLT for short). The #VOLT is filled with receptors that detect IL-1 and other cytokines.

That, along with its proximity to our #homeostat hypothalamus, means it’s positioned perfectly to sense an ongoing immune response and initiate our brain and body’s many defensive tactics.

After receiving signals from the VOLT, the hypothalamus creates many of the familiar experiences of sickness

https://pennneuroknow.com/2023/06/27/healing-from-the-hypothalamus/

A molecular network map of orexin-orexin receptor signaling system. https://doi.org/10.1007/s12079-022-00700-3 #Orexin #Pathvisio #Sleep #Feeding #Hypothalamus

Happy to share our new article, which has been in the making for a veeery long time!

https://insight.jci.org/articles/view/165763

In this study we looked at the control of the entrance of #ghrelin in the #brain

Ghrelin is a #hormone produced by the stomach, which induces hunger. In order to do so, ghrelin needs to enter the brain, to reach neurons in the arcuate nucleus of the #hypothalamus, a region of the brain important for many #endocrine responses.

Here, we explore the role of cells lining the capillaries (such as #perycytes ) at the median eminence, which is on of the "doors" of the brain, where molecules from the periphery are allowed to get in.

We used a mouse model where pericytes can be electrically excited via #optogenetics to study the dynamics of ghrelin entrance in the brain. When we excited pericytes, there was a slow-down of blood flow at the median eminence, resulting in slower entrance of ghrelin, lower and delayed food intake in response to ghrelin injection.

This shows pericytes as a potential therapeutical target for metabolic diseases.

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