#bonumce — Public Fediverse posts

4/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

⌚️Understanding timing of onset helps us better understand, differentiate, & manage TKI & ICI-related AEs 👇

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟠Earn 🆓 #CME 🏆
🟠#CME ℹ️🔗http://bit.ly/3YRDkog

📸 Faculty disclosures & important CME info 👇

5/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer
#CME 🔗http://bit.ly/3YRDkog

🟢#PreTest Q 4️⃣
📊During treatment w pembro + lenva, pt develops grade 3 HTN
🟢What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

17/#TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

🔬Research needed to ⬇️ tox while maintaining efficacy

❓Alternative dosing strategies (incl. dose breaks)
❓Effects of dose ⬇️ on pt outcomes
❓Effects of reduced ▶️ dose on pt outcomes

15/ #TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

🟢Pt w mRCC
🔸Initiated tx w pembro + lenva
🔹Developed G3 diarrhea
🔸Lenva withheld & anti-diarrheal treatment initiated 🔹Diarrhea now resolved.

🟢What next step is best for the pt?

14/#TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

Effective tox mgmt ➡️optimize pt outcomes✅

🩺 Mgmt strategies include...🩺
🔹Prevention
🔸Monitor BP, urine protein, thyroid & liver function
🔹Dose modification (⏸️⬇️🛑)
🔸Supportive care

13/#TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

🔬Common tox in pivotal P3 #CHECKMATE214 trial of dual ICI combo🔬
🔸Fatigue
🔹Pruritus
🔸Diarrhea
🔹Rash
🔸Nausea

12/#TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

🔬Common tox in pivotal Phase 3 trials of TKI-ICI combos🔬
#KEYNOTE426 #CLEAR #CHECKMATE9ER #JAVELINrenal101
🔹Diarrhea
🔸HTN
🔹Hypothyroidism
🔸Fatigue
🔹PPES
🔸Loss of appetite

11/ #TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

Some AEs attributable to either drug
These🔂overlapping tox can complicate pt mgmt

10/ #TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

🟢Which of the following is an AE that is commonly observed with both ICIs and TKIs?

7/ #TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

🟢Which of the following is a characteristic feature of the most common toxicities associated with anti-angiogenic therapies?

8/#TumorBoardTuesday #BonumCE #RenalCell

Combo tx =possible⬆️tox➡️can lead to trtmnt🛑

✨Anti-angio inhibitors=multi🎯TKIs
✨AEs related to shared 🎯s (e.g. VEGFR)=predictable class tox
✨Some nuance due 2 diff🎯/potency
✨Typ occur 1st few wks of ▶️tx
✨Broadly dose-dependent

6/ #TumorBoardTuesday #BonumCE #OncTwitter #NephTwitter #MedTwitter #RenalCell

✳️Dual ICI combo (ipi + nivo) also approved tx option

💎#CheckMate214 - ipi + nivo vs sunitinib
✅Longest follow-up in frontline RCC (>5 years)
✅OS and PFS favor combo tx in int/poor risk pts

4/ #TumorBoardTuesday #BonumCE #OncTwitter #RenalCell

💎Combo txs as SOC for 1st line mRCC💎

TKI/ICI combos:
🔸#lenvatinib (TKI) + #pembrolizumab (PD-1 mAb)
🔸#axitinib (TKI) + pembro
🔸#cabozantinib (TKI) + #nivolumab (PD-1 mAb)

Dual ICI combo:
🔸#ipilimumab (CTLA-4) + nivo

4/ #TumorBoardTuesday #BonumCE #OncTwitter #RenalCell

💎Combo txs as SOC for 1st line mRCC💎

TKI/ICI combos:
🔸#lenvatinib (TKI) + #pembrolizumab (PD-1 mAb)
🔸#axitinib (TKI) + pembro
🔸#cabozantinib (TKI) + #nivolumab (PD-1 mAb)

Dual ICI combo:
🔸#ipilimumab (CTLA-4) + nivo

4/ #TumorBoardTuesday #BonumCE #OncTwitter #RenalCell

💎Combo txs as SOC for 1st line mRCC💎

TKI/ICI combos:
🔸#lenvatinib (TKI) + #pembrolizumab (PD-1 mAb)
🔸#axitinib (TKI) + pembro
🔸#cabozantinib (TKI) + #nivolumab (PD-1 mAb)

Dual ICI combo:
🔸#ipilimumab (CTLA-4) + nivo

3/ #TumorBoardTuesday #BonumCE #RenalCell
#OncTwitter #NephTwitter #MedTwitter

🟢 Which of the following TKI/IO combo regimens is 🚫NOT approved by the FDA for the frontline mgmt of #RenalCell carcinoma?

2/ #TumorBoardTuesday #BonumCE #RenalCell #OncTwitter #NephTwitter
🆓#CME info ➕ full ref list🗒️ 👉 http://bit.ly/3VDaK81

✳️The critical elements👇