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https://www.nytimes.com/2023/02/01/health/ovarian-cancer-fallopian-tubes.html?referringSource=articleShare

Next #TumorBoardTuesday 🧵 you may have missed

⏪ Rewind ⏪ to our fabulous fireside chat featuring a brief discussion on safety & management of #EndometrialCancer with @DrMMurphy @drteplinsky

Sit back & listen while grabbing a bite to eat.
#gyncsm
---
RT @TumorBoardTues
💥#EndometrialCancer TKI/IO safety data & AE mgmt webinar 💥┈┈┈ w @DrMMurphy & @drteplinsky ┈┈┈🔹#CME info 👉 http://bit.ly/3Vqtabi 👈 @BonumCe ┈┈┈🔸Supported by edu gra…
https://twitter.com/TumorBoardTues/status/1616239139082625024

Next #TumorBoardTuesday 🧵 you may have missed

⏪ Rewind ⏪ to our fabulous fireside chat featuring a brief discussion on safety & management of #EndometrialCancer with @DrMMurphy @drteplinsky

Sit back & listen while grabbing a bite to eat.
#gyncsm
---
RT @TumorBoardTues
💥#EndometrialCancer TKI/IO safety data & AE mgmt webinar 💥┈┈┈ w @DrMMurphy & @drteplinsky ┈┈┈🔹#CME info 👉 http://bit.ly/3Vqtabi 👈 @BonumCe ┈┈┈🔸Supported by edu gra…
https://twitter.com/TumorBoardTues/status/1616239139082625024

8/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

#CME🔗http://bit.ly/3hYxu3R

🔴#PostTest Q4️⃣
During treatment w pembro + lenva, pt develops grade 3 HTN
🔴What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

8/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

#CME🔗http://bit.ly/3hYxu3R

🔴#PostTest Q4️⃣
During treatment w pembro + lenva, pt develops grade 3 HTN
🔴What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

7/#TumorBoardTuesday #GynCSM

🔴#PostTest Q3️⃣
📊Pt receiving pembro + lenva combo for past 12m
🗓@ f/u presented w persistently high levels of TSH
🟥Lenva withheld, but TSH levels remain high (>10mIU/L)

🔴What is the most appropriate next step in the mgmt of this pt?

7/#TumorBoardTuesday #GynCSM

🔴#PostTest Q3️⃣
📊Pt receiving pembro + lenva combo for past 12m
🗓@ f/u presented w persistently high levels of TSH
🟥Lenva withheld, but TSH levels remain high (>10mIU/L)

🔴What is the most appropriate next step in the mgmt of this pt?

6/#TumorBoardTuesday #BonumCE #GynCSM #EndometrialCancer
#CME 🔗http://bit.ly/3hYxu3R

🔴#PostTest Q 2️⃣
📊During tx w pembro + lenva, pt develops grd 3 diarrhea
🛑Lenva held
💊Loperamide Rx
Grade3️⃣diarrhea persists

🔴Which is the appropriate next step for this pt?

5/ Thanks #TumorBoardTuesday & #gyncsm!

🏆Claim #CME http://bit.ly/3hYxu3R
⬇️Answer #PostTest👇

🔴#PostTest Q1️⃣
📊Diarrhea, nausea, & vomiting are common GI tox associated w pembro + lenvatinib combo tx
🔴Which other tox may occur if these GI tox r not effectively managed?

6/#TumorBoardTuesday #BonumCE #GynCSM #EndometrialCancer
#CME 🔗http://bit.ly/3hYxu3R

🔴#PostTest Q 2️⃣
📊During tx w pembro + lenva, pt develops grd 3 diarrhea
🛑Lenva held
💊Loperamide Rx
Grade3️⃣diarrhea persists

🔴Which is the appropriate next step for this pt?

5/ Thanks #TumorBoardTuesday & #gyncsm!

🏆Claim #CME http://bit.ly/3hYxu3R
⬇️Answer #PostTest👇

🔴#PostTest Q1️⃣
📊Diarrhea, nausea, & vomiting are common GI tox associated w pembro + lenvatinib combo tx
🔴Which other tox may occur if these GI tox r not effectively managed?

4/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

⌚️Understanding timing of onset helps us better understand, differentiate, & manage TKI & ICI-related AEs 👇

4/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

⌚️Understanding timing of onset helps us better understand, differentiate, & manage TKI & ICI-related AEs 👇

4/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

⌚️Understanding timing of onset helps us better understand, differentiate, & manage TKI & ICI-related AEs 👇

3/#TumorBoardTuesday #gyncsm #OncTwitter

🤔Missed the #EndometrialCancer #MedTweetorial earlier this wk?
🤯Feeling left behind?

Don't fret, it's here📍

---
RT @BonumCe
1/ #OncTwitter #TumorBoardTuesday
✅#EndometrialCancer #MedTweetorial🧵
w @DrMMurphy @MeganLeigh127 @TumorBoardTues

🧬Tx response
🧪Trial results
🔬Tox for TKI-ICI

🆓#CME 🔗 http://bit.ly/3VBGJEJ
Supported by educational grants from Eisai & @Merck
https://twitter.com/BonumCe/status/1615519240542646275

3/#TumorBoardTuesday #gyncsm #OncTwitter

🤔Missed the #EndometrialCancer #MedTweetorial earlier this wk?
🤯Feeling left behind?

Don't fret, it's here📍

---
RT @BonumCe
1/ #OncTwitter #TumorBoardTuesday
✅#EndometrialCancer #MedTweetorial🧵
w @DrMMurphy @MeganLeigh127 @TumorBoardTues

🧬Tx response
🧪Trial results
🔬Tox for TKI-ICI

🆓#CME 🔗 http://bit.ly/3VBGJEJ
Supported by educational grants from Eisai & @Merck
https://twitter.com/BonumCe/status/1615519240542646275

3/#TumorBoardTuesday #gyncsm #OncTwitter

🤔Missed the #EndometrialCancer #MedTweetorial earlier this wk?
🤯Feeling left behind?

Don't fret, it's here📍

---
RT @BonumCe
1/ #OncTwitter #TumorBoardTuesday
✅#EndometrialCancer #MedTweetorial🧵
w @DrMMurphy @MeganLeigh127 @TumorBoardTues

🧬Tx response
🧪Trial results
🔬Tox for TKI-ICI

🆓#CME 🔗 http://bit.ly/3VBGJEJ
Supported by educational grants from Eisai & @Merck
https://twitter.com/BonumCe/status/1615519240542646275

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟠Earn 🆓 #CME 🏆
🟠#CME ℹ️🔗http://bit.ly/3YRDkog

📸 Faculty disclosures & important CME info 👇

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟠Earn 🆓 #CME 🏆
🟠#CME ℹ️🔗http://bit.ly/3YRDkog

📸 Faculty disclosures & important CME info 👇

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟠Earn 🆓 #CME 🏆
🟠#CME ℹ️🔗http://bit.ly/3YRDkog

📸 Faculty disclosures & important CME info 👇

💥#EndometrialCancer TKI/IO safety data & AE mgmt webinar 💥┈┈┈ w @DrMMurphy & @drteplinsky ┈┈┈🔹#CME info 👉 http://bit.ly/3Vqtabi 👈 @BonumCe ┈┈┈🔸Supported by edu grants from Eisai & @Merck 🔹#TumorBoardTuesday #gyncsm #OncTwitter https://twitter.com/i/broadcasts/1yoJMZrrqbNxQ

💥#EndometrialCancer TKI/IO safety data & AE mgmt webinar 💥┈┈┈ w @DrMMurphy & @drteplinsky ┈┈┈🔹#CME info 👉 http://bit.ly/3Vqtabi 👈 @BonumCe ┈┈┈🔸Supported by edu grants from Eisai & @Merck 🔹#TumorBoardTuesday #gyncsm #OncTwitter https://twitter.com/i/broadcasts/1yoJMZrrqbNxQ

💥#EndometrialCancer TKI/IO safety data & AE mgmt webinar 💥┈┈┈ w @DrMMurphy & @drteplinsky ┈┈┈🔹#CME info 👉 http://bit.ly/3Vqtabi 👈 @BonumCe ┈┈┈🔸Supported by edu grants from Eisai & @Merck 🔹#TumorBoardTuesday #gyncsm #OncTwitter https://twitter.com/i/broadcasts/1yoJMZrrqbNxQ

5...4...3...2...1...it's the final countdown
⏰30m warning
🔥#EndometrialCancer #webinar w @DrMMurphy & @drteplinsky🔥

👩‍🏫B4 we begin...👩🏻‍🏫
✅Answer #PreTest polls 👇
🔁Retweet & tag colleagues

#TumorBoardTuesday #OncTwitter #MedTwitter #GynCSM #gynonc

---
RT @TumorBoardTues
2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w…
https://twitter.com/TumorBoardTues/status/1616204008028528643

5...4...3...2...1...it's the final countdown
⏰30m warning
🔥#EndometrialCancer #webinar w @DrMMurphy & @drteplinsky🔥

👩‍🏫B4 we begin...👩🏻‍🏫
✅Answer #PreTest polls 👇
🔁Retweet & tag colleagues

#TumorBoardTuesday #OncTwitter #MedTwitter #GynCSM #gynonc

---
RT @TumorBoardTues
2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w…
https://twitter.com/TumorBoardTues/status/1616204008028528643

5...4...3...2...1...it's the final countdown
⏰30m warning
🔥#EndometrialCancer #webinar w @DrMMurphy & @drteplinsky🔥

👩‍🏫B4 we begin...👩🏻‍🏫
✅Answer #PreTest polls 👇
🔁Retweet & tag colleagues

#TumorBoardTuesday #OncTwitter #MedTwitter #GynCSM #gynonc

---
RT @TumorBoardTues
2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w…
https://twitter.com/TumorBoardTues/status/1616204008028528643

5/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer
#CME 🔗http://bit.ly/3YRDkog

🟢#PreTest Q 4️⃣
📊During treatment w pembro + lenva, pt develops grade 3 HTN
🟢What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

5/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer
#CME 🔗http://bit.ly/3YRDkog

🟢#PreTest Q 4️⃣
📊During treatment w pembro + lenva, pt develops grade 3 HTN
🟢What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

5/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer
#CME 🔗http://bit.ly/3YRDkog

🟢#PreTest Q 4️⃣
📊During treatment w pembro + lenva, pt develops grade 3 HTN
🟢What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

4/#TumorBoardTuesday #GynCSM
🟢#PreTest Q 3️⃣

📊Pt receiving pembro + lenva combo for past 12m
🗓@ f/u presented w persistently high levels of TSH
🟥Lenva withheld, but TSH levels remain high (>10mIU/L)

🟢What is the most appropriate next step in the mgmt of this pt?

4/#TumorBoardTuesday #GynCSM
🟢#PreTest Q 3️⃣

📊Pt receiving pembro + lenva combo for past 12m
🗓@ f/u presented w persistently high levels of TSH
🟥Lenva withheld, but TSH levels remain high (>10mIU/L)

🟢What is the most appropriate next step in the mgmt of this pt?

4/#TumorBoardTuesday #GynCSM
🟢#PreTest Q 3️⃣

📊Pt receiving pembro + lenva combo for past 12m
🗓@ f/u presented w persistently high levels of TSH
🟥Lenva withheld, but TSH levels remain high (>10mIU/L)

🟢What is the most appropriate next step in the mgmt of this pt?

3/#TumorBoardTuesday #GynCSM #EndometrialCancer
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 2️⃣
📊During tx w pembro + lenvatinib, pt develops grade 3 diarrhea
🛑Lenva held
💊Loperamide Rx
Grade3️⃣diarrhea persists

🟢What is the next step for this pt?
(cs=corticosteroid)

3/#TumorBoardTuesday #GynCSM #EndometrialCancer
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 2️⃣
📊During tx w pembro + lenvatinib, pt develops grade 3 diarrhea
🛑Lenva held
💊Loperamide Rx
Grade3️⃣diarrhea persists

🟢What is the next step for this pt?
(cs=corticosteroid)

3/#TumorBoardTuesday #GynCSM #EndometrialCancer
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 2️⃣
📊During tx w pembro + lenvatinib, pt develops grade 3 diarrhea
🛑Lenva held
💊Loperamide Rx
Grade3️⃣diarrhea persists

🟢What is the next step for this pt?
(cs=corticosteroid)

2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w pembro + lenvatinib combo therapy

🟢Which other tox may occur if these GI toxicities are not effectively managed?

2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w pembro + lenvatinib combo therapy

🟢Which other tox may occur if these GI toxicities are not effectively managed?

2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w pembro + lenvatinib combo therapy

🟢Which other tox may occur if these GI toxicities are not effectively managed?

26/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️http://bit.ly/3jCyVFJ

🔴 Post Poll 4️⃣
🔴During treatment w pembro & lenva, pt develops frequent, loose, watery stools. How could you quickly determine which drug is causing the diarrhea?

26/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️http://bit.ly/3jCyVFJ

🔴 Post Poll 4️⃣
🔴During treatment w pembro & lenva, pt develops frequent, loose, watery stools. How could you quickly determine which drug is causing the diarrhea?

25/ #TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

#CME➡️http://bit.ly/3jCyVFJ 🏆

🔴Post Poll 3️⃣
🔴During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

25/ #TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

#CME➡️http://bit.ly/3jCyVFJ 🏆

🔴Post Poll 3️⃣
🔴During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

24/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️ http://bit.ly/3jCyVFJ

🔴Post Poll2️⃣
🔴What is the most common grade 3 or higher toxicity associated w the combo of pembro & lenva in pts w #EndometrialCancer?

24/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️ http://bit.ly/3jCyVFJ

🔴Post Poll2️⃣
🔴What is the most common grade 3 or higher toxicity associated w the combo of pembro & lenva in pts w #EndometrialCancer?

23/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

Thanks for joining!
👋Claim🆓#CME👉http://bit.ly/3jCyVFJ
🛑Before you leave…answer polls👇

🔴Post Poll1️⃣
🔴Which I/O +🎯tx combo is FDA approved for treatment of advanced or metastatic #EndometrialCarcinoma?

23/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

Thanks for joining!
👋Claim🆓#CME👉http://bit.ly/3jCyVFJ
🛑Before you leave…answer polls👇

🔴Post Poll1️⃣
🔴Which I/O +🎯tx combo is FDA approved for treatment of advanced or metastatic #EndometrialCarcinoma?

21/#TumorBoardTuesday #GynCSM

Overlapping tox: some AEs attributable to either drug
✅Need to ID etiology to choose correct mgmt strategy
⏱TKI ½-life allows rapid drug washout➡️w/hold lenva + see if tox resolves
Common overlapping tox: diarrhea, fatigue, rash, hypothyroidism

21/#TumorBoardTuesday #GynCSM

Overlapping tox: some AEs attributable to either drug
✅Need to ID etiology to choose correct mgmt strategy
⏱TKI ½-life allows rapid drug washout➡️w/hold lenva + see if tox resolves
Common overlapping tox: diarrhea, fatigue, rash, hypothyroidism

20/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟢During treatment w pembro & lenva, pt develops frequent, loose, watery stools

How could you quickly determine which drug is causing the diarrhea?

19/#TumorBoardTuesday #GynCSM #EndometrialCancer

🚨Pembro-related immune tox🚨
🔸Can affect any organ @ any time during/after tx
🔹Can become severe/fatal if not promptly dx & tx
🔸Typically reversible (excl. endocrine)
🔹Managed w immunosuppressive tx - mainly corticosteroids

20/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟢During treatment w pembro & lenva, pt develops frequent, loose, watery stools

How could you quickly determine which drug is causing the diarrhea?

19/#TumorBoardTuesday #GynCSM #EndometrialCancer

🚨Pembro-related immune tox🚨
🔸Can affect any organ @ any time during/after tx
🔹Can become severe/fatal if not promptly dx & tx
🔸Typically reversible (excl. endocrine)
🔹Managed w immunosuppressive tx - mainly corticosteroids

17/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

45.6% pts ≥2 ⬇️lenva dose#KEYNOTE775
🔸Often need new 30d dose pack b4 finishing current supply

🆕Eisai dose exchange program - cover all indicated dose⬇️🔗http://bit.ly/3gYHvOd

17/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

45.6% pts ≥2 ⬇️lenva dose#KEYNOTE775
🔸Often need new 30d dose pack b4 finishing current supply

🆕Eisai dose exchange program - cover all indicated dose⬇️🔗http://bit.ly/3gYHvOd

16/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

💊 Lenva dose mods = dose reduce⬇️or withhold🛑for more severe tox

Recommended lenva starting ▶️dose adv EC: 20mg QD
🥇1st dose⬇️14mg
🥈2nd dose⬇️10mg
🥉3rd dose⬇️8mg

16/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

💊 Lenva dose mods = dose reduce⬇️or withhold🛑for more severe tox

Recommended lenva starting ▶️dose adv EC: 20mg QD
🥇1st dose⬇️14mg
🥈2nd dose⬇️10mg
🥉3rd dose⬇️8mg

15/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

🟢During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

15/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

🟢During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

14/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🚨VEGFR TKI-related class tox e.g. HTN, proteinuria
🗓Typ occur 1st few wks tx
💊Dose-dependent
🧮Managed w dose mods & supportive care (e.g. anti-hypertensive)

14/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🚨VEGFR TKI-related class tox e.g. HTN, proteinuria
🗓Typ occur 1st few wks tx
💊Dose-dependent
🧮Managed w dose mods & supportive care (e.g. anti-hypertensive)