#gynonc — Public Fediverse posts

8/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

#CME🔗http://bit.ly/3hYxu3R

🔴#PostTest Q4️⃣
During treatment w pembro + lenva, pt develops grade 3 HTN
🔴What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

8/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

#CME🔗http://bit.ly/3hYxu3R

🔴#PostTest Q4️⃣
During treatment w pembro + lenva, pt develops grade 3 HTN
🔴What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

4/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

⌚️Understanding timing of onset helps us better understand, differentiate, & manage TKI & ICI-related AEs 👇

4/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

⌚️Understanding timing of onset helps us better understand, differentiate, & manage TKI & ICI-related AEs 👇

4/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

⌚️Understanding timing of onset helps us better understand, differentiate, & manage TKI & ICI-related AEs 👇

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟠Earn 🆓 #CME 🏆
🟠#CME ℹ️🔗http://bit.ly/3YRDkog

📸 Faculty disclosures & important CME info 👇

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟠Earn 🆓 #CME 🏆
🟠#CME ℹ️🔗http://bit.ly/3YRDkog

📸 Faculty disclosures & important CME info 👇

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟠Earn 🆓 #CME 🏆
🟠#CME ℹ️🔗http://bit.ly/3YRDkog

📸 Faculty disclosures & important CME info 👇

5...4...3...2...1...it's the final countdown
⏰30m warning
🔥#EndometrialCancer #webinar w @DrMMurphy & @drteplinsky🔥

👩‍🏫B4 we begin...👩🏻‍🏫
✅Answer #PreTest polls 👇
🔁Retweet & tag colleagues

#TumorBoardTuesday #OncTwitter #MedTwitter #GynCSM #gynonc

---
RT @TumorBoardTues
2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w…
https://twitter.com/TumorBoardTues/status/1616204008028528643

5...4...3...2...1...it's the final countdown
⏰30m warning
🔥#EndometrialCancer #webinar w @DrMMurphy & @drteplinsky🔥

👩‍🏫B4 we begin...👩🏻‍🏫
✅Answer #PreTest polls 👇
🔁Retweet & tag colleagues

#TumorBoardTuesday #OncTwitter #MedTwitter #GynCSM #gynonc

---
RT @TumorBoardTues
2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w…
https://twitter.com/TumorBoardTues/status/1616204008028528643

5...4...3...2...1...it's the final countdown
⏰30m warning
🔥#EndometrialCancer #webinar w @DrMMurphy & @drteplinsky🔥

👩‍🏫B4 we begin...👩🏻‍🏫
✅Answer #PreTest polls 👇
🔁Retweet & tag colleagues

#TumorBoardTuesday #OncTwitter #MedTwitter #GynCSM #gynonc

---
RT @TumorBoardTues
2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w…
https://twitter.com/TumorBoardTues/status/1616204008028528643

5/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer
#CME 🔗http://bit.ly/3YRDkog

🟢#PreTest Q 4️⃣
📊During treatment w pembro + lenva, pt develops grade 3 HTN
🟢What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

5/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer
#CME 🔗http://bit.ly/3YRDkog

🟢#PreTest Q 4️⃣
📊During treatment w pembro + lenva, pt develops grade 3 HTN
🟢What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

5/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer
#CME 🔗http://bit.ly/3YRDkog

🟢#PreTest Q 4️⃣
📊During treatment w pembro + lenva, pt develops grade 3 HTN
🟢What is the most effective mgmt strategy for this patient? (CS = corticosteroid)

2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w pembro + lenvatinib combo therapy

🟢Which other tox may occur if these GI toxicities are not effectively managed?

2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w pembro + lenvatinib combo therapy

🟢Which other tox may occur if these GI toxicities are not effectively managed?

2/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc
#CME🔗http://bit.ly/3YRDkog

🟢#PreTest Q 1️⃣
📊Diarrhea, nausea, & vomiting are common GI toxicities associated w pembro + lenvatinib combo therapy

🟢Which other tox may occur if these GI toxicities are not effectively managed?

26/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️http://bit.ly/3jCyVFJ

🔴 Post Poll 4️⃣
🔴During treatment w pembro & lenva, pt develops frequent, loose, watery stools. How could you quickly determine which drug is causing the diarrhea?

26/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️http://bit.ly/3jCyVFJ

🔴 Post Poll 4️⃣
🔴During treatment w pembro & lenva, pt develops frequent, loose, watery stools. How could you quickly determine which drug is causing the diarrhea?

25/ #TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

#CME➡️http://bit.ly/3jCyVFJ 🏆

🔴Post Poll 3️⃣
🔴During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

25/ #TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

#CME➡️http://bit.ly/3jCyVFJ 🏆

🔴Post Poll 3️⃣
🔴During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

24/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️ http://bit.ly/3jCyVFJ

🔴Post Poll2️⃣
🔴What is the most common grade 3 or higher toxicity associated w the combo of pembro & lenva in pts w #EndometrialCancer?

24/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🏆#CME➡️ http://bit.ly/3jCyVFJ

🔴Post Poll2️⃣
🔴What is the most common grade 3 or higher toxicity associated w the combo of pembro & lenva in pts w #EndometrialCancer?

23/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

Thanks for joining!
👋Claim🆓#CME👉http://bit.ly/3jCyVFJ
🛑Before you leave…answer polls👇

🔴Post Poll1️⃣
🔴Which I/O +🎯tx combo is FDA approved for treatment of advanced or metastatic #EndometrialCarcinoma?

23/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

Thanks for joining!
👋Claim🆓#CME👉http://bit.ly/3jCyVFJ
🛑Before you leave…answer polls👇

🔴Post Poll1️⃣
🔴Which I/O +🎯tx combo is FDA approved for treatment of advanced or metastatic #EndometrialCarcinoma?

20/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟢During treatment w pembro & lenva, pt develops frequent, loose, watery stools

How could you quickly determine which drug is causing the diarrhea?

20/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🟢During treatment w pembro & lenva, pt develops frequent, loose, watery stools

How could you quickly determine which drug is causing the diarrhea?

17/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

45.6% pts ≥2 ⬇️lenva dose#KEYNOTE775
🔸Often need new 30d dose pack b4 finishing current supply

🆕Eisai dose exchange program - cover all indicated dose⬇️🔗http://bit.ly/3gYHvOd

17/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

45.6% pts ≥2 ⬇️lenva dose#KEYNOTE775
🔸Often need new 30d dose pack b4 finishing current supply

🆕Eisai dose exchange program - cover all indicated dose⬇️🔗http://bit.ly/3gYHvOd

16/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

💊 Lenva dose mods = dose reduce⬇️or withhold🛑for more severe tox

Recommended lenva starting ▶️dose adv EC: 20mg QD
🥇1st dose⬇️14mg
🥈2nd dose⬇️10mg
🥉3rd dose⬇️8mg

16/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

💊 Lenva dose mods = dose reduce⬇️or withhold🛑for more severe tox

Recommended lenva starting ▶️dose adv EC: 20mg QD
🥇1st dose⬇️14mg
🥈2nd dose⬇️10mg
🥉3rd dose⬇️8mg

15/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

🟢During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

15/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

🟢During tx w/ pembro-lenva, a pt develops grade 3 HTN requiring reduction in lenva. Starting dose of lenva was 20mg.

Which dose is recommended for lenva now?

14/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🚨VEGFR TKI-related class tox e.g. HTN, proteinuria
🗓Typ occur 1st few wks tx
💊Dose-dependent
🧮Managed w dose mods & supportive care (e.g. anti-hypertensive)

14/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

🚨VEGFR TKI-related class tox e.g. HTN, proteinuria
🗓Typ occur 1st few wks tx
💊Dose-dependent
🧮Managed w dose mods & supportive care (e.g. anti-hypertensive)

12/#TumorBoardTuesday #GynCSM #gynonc #EndometrialCancer

✏️Lenva-pembro tox distinct from chemotx
✏️Safety profile of combo tx consistent w those of individual agents
✏️Most common any grade & grade 3+TRAE = HTN
✏️Shortest⏱to onset: HTN
✏️Later: hypothyroidism & weight loss⬇️

12/#TumorBoardTuesday #GynCSM #gynonc #EndometrialCancer

✏️Lenva-pembro tox distinct from chemotx
✏️Safety profile of combo tx consistent w those of individual agents
✏️Most common any grade & grade 3+TRAE = HTN
✏️Shortest⏱to onset: HTN
✏️Later: hypothyroidism & weight loss⬇️

11/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🟢What is the most common grade 3 or higher toxicity associated w/ the combination of pembro & lenva in pts w/ #EndometrialCancer?

11/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc

🟢What is the most common grade 3 or higher toxicity associated w/ the combination of pembro & lenva in pts w/ #EndometrialCancer?

9/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

⚙️Lenva=multi🎯TKI (incl VEGFR)
🛑Blocks angiogenic signaling
VEGFR signals also have immunosuppressive role

⚙️Pembro=ICI
💪Boosts anti-tumor immune response

🔑Combo tx=synergistic anti-tumor activity

9/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

⚙️Lenva=multi🎯TKI (incl VEGFR)
🛑Blocks angiogenic signaling
VEGFR signals also have immunosuppressive role

⚙️Pembro=ICI
💪Boosts anti-tumor immune response

🔑Combo tx=synergistic anti-tumor activity

8/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

Pivotal trials leading to FDA approval in 2L met MSI-H/dMMR #EndometrialCarcinoma

🔸Pembro: #KEYNOTE158 (phase 2)
🔹Dostarlimab: #GARNET (phase 1)

🔑Efficacy & safety data 📷👇

8/#TumorBoardTuesday #BonumCE #OncTwitter #GynCSM #gynonc #EndometrialCancer

Pivotal trials leading to FDA approval in 2L met MSI-H/dMMR #EndometrialCarcinoma

🔸Pembro: #KEYNOTE158 (phase 2)
🔹Dostarlimab: #GARNET (phase 1)

🔑Efficacy & safety data 📷👇

7/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc

🧬Faulty DNA repair (dMMR/MSI-H)➡️high tumor mutation burden
➡️more tumor neoantigens
➡️sensitivity to ICI

💎Two FDA approved ICIs in dMMR/MSI-H #EndometrialCancer:
🔹Pembro (PD-1 mAb)
🔹Dostarlimab (PD-1 mAb)

7/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc

🧬Faulty DNA repair (dMMR/MSI-H)➡️high tumor mutation burden
➡️more tumor neoantigens
➡️sensitivity to ICI

💎Two FDA approved ICIs in dMMR/MSI-H #EndometrialCancer:
🔹Pembro (PD-1 mAb)
🔹Dostarlimab (PD-1 mAb)

6/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc

After progression on chemotx, tx for metastatic #EndometrialCancer is influenced by tumor molecular subtype

🧬Cancer Genome Atlas ID’d 4️⃣ mol subclasses…
1️⃣POLE ultramutated
2️⃣dMMR/MSI-H
3️⃣Copy # low
4️⃣Copy # high

6/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc

After progression on chemotx, tx for metastatic #EndometrialCancer is influenced by tumor molecular subtype

🧬Cancer Genome Atlas ID’d 4️⃣ mol subclasses…
1️⃣POLE ultramutated
2️⃣dMMR/MSI-H
3️⃣Copy # low
4️⃣Copy # high

5/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc

#EndometrialCancer most common gyn cancer in🇺🇸

Rates 📈
Est in 2022…
📊New cases: 69,950
📊Deaths: 12,550

Most pts dx early stage - gd prognosis✅

Approx 9% dx met disease➡️5y survival <20%➡️plat chemo SOC 1st line tx

5/#TumorBoardTuesday #OncTwitter #GynCSM #gynonc

#EndometrialCancer most common gyn cancer in🇺🇸

Rates 📈
Est in 2022…
📊New cases: 69,950
📊Deaths: 12,550

Most pts dx early stage - gd prognosis✅

Approx 9% dx met disease➡️5y survival <20%➡️plat chemo SOC 1st line tx

4/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

If you picked pembro + lenva…
You’re right🎉

Pembro (PD-1🎯mAb) + lenva (multi-🎯TKI)
➡️🏁accelerated approval adv EC in 2019

Ph3 confirmatory trial✅➡️#KEYNOTE-775
➡️full FDA approval 2021

4/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer

If you picked pembro + lenva…
You’re right🎉

Pembro (PD-1🎯mAb) + lenva (multi-🎯TKI)
➡️🏁accelerated approval adv EC in 2019

Ph3 confirmatory trial✅➡️#KEYNOTE-775
➡️full FDA approval 2021

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynOnc #gyncsm #EndometrialCancer

🟢Which I/O +🎯tx combo is FDA approved for treatment of advanced or metastatic #EndometrialCarcinoma?

nivo = nivolumab
dostarlimab = dostarlimab-gxly
pembro = pembrolizumab

3/#TumorBoardTuesday #BonumCE #OncTwitter #GynOnc #gyncsm #EndometrialCancer

🟢Which I/O +🎯tx combo is FDA approved for treatment of advanced or metastatic #EndometrialCarcinoma?

nivo = nivolumab
dostarlimab = dostarlimab-gxly
pembro = pembrolizumab

2/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer #MedTweetorial

🆓 CME > full info➕ref list🗒️& program archive
👉http://bit.ly/3VBGJEJ

🔑#CME info👇

2/#TumorBoardTuesday #BonumCE #OncTwitter #gyncsm #gynonc #EndometrialCancer #MedTweetorial

🆓 CME > full info➕ref list🗒️& program archive
👉http://bit.ly/3VBGJEJ

🔑#CME info👇

An potential explanation for 'chemobrain' comes from neuronal DNA damage response; #gynonc; https://www.science.org/doi/10.1126/science.add9838

An potential explanation for 'chemobrain' comes from neuronal DNA damage response; #gynonc; https://www.science.org/doi/10.1126/science.add9838

An potential explanation for 'chemobrain' comes from neuronal DNA damage response; #gynonc; https://www.science.org/doi/10.1126/science.add9838

An potential explanation for 'chemobrain' comes from neuronal DNA damage response; #gynonc; https://www.science.org/doi/10.1126/science.add9838

Happy to be here on med-mastodon. I will mostly toot about academic issues and new peer-reviewed articles related to gynecologic oncology #gynonc #twittermigration