Live and recent posts from across the Fediverse tagged #sirtuins, aggregated by home.social.
PARP1 (PDB: 4DQY) — catalytic core resolves NAD⁺ positioning (H133/E134/Mg²⁺) and substrate interface (326–332) as structurally separable sites. E134 as the ADP-ribose acceptor base.
Age-associated DNA damage → PARP1 hyperactivation → NAD⁺ depletion → SIRT1/3 inactivation → mitochondrial dysfunction. A structurally grounded feedforward loop in biological aging.
#PARP1 #NAD #StructuralBiology #LongevityBiology #Aging #DNARepair #Biogerontology #Sirtuins
Sirtuins = cellular longevity switches 🧬
These NAD+-dependent proteins:
✅ Repair DNA damage
✅ Boost mitochondrial health
✅ Regulate metabolism
✅ Enhance stress resistance
SIRT1-7 family = evolutionarily conserved across species
Key interventions:
→ NAD+ precursors (NR/NMN)
→ Caloric restriction
→ Small molecule activators
The challenge? Moving from mouse models to validated human therapeutics.