#sialic — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #sialic, aggregated by home.social.
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#H19 #influenza A virus exhibits #species-specific #MHC class II #receptor usage, Cell Host Microbe: https://www.cell.com/cell-host-microbe/abstract/S1931-3128(24)00190-2?rss=yes
Influenza A virus H19 subtype does not bind the canonical receptor #sialic acid. H19 utilizes MHC class II #proteins from distinct species for host cell entry.
Mutating the putative canonical RBS of H19 restores sialic acid dependency. Residues in the MHC class II α chain confer species-specific entry of H19. -
#Pathogenicity and #transmissibility of #bovine #H5N1 #influenza virus, Nature: https://www.nature.com/articles/s41586-024-07766-6
Importantly, bovine HPAI H5N1 virus bound to #sialic acids expressed in #human upper #airways and inefficiently transmitted to exposed ferrets (one of four exposed ferrets seroconverted without virus detection). Bovine HPAI H5N1 virus thus possesses features that may facilitate #infection and #transmission in #mammals.
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#Pathogenicity and #transmissibility of #bovine #H5N1 #influenza virus, Nature: https://www.nature.com/articles/s41586-024-07766-6
Importantly, bovine HPAI H5N1 virus bound to #sialic acids expressed in #human upper #airways and inefficiently transmitted to exposed ferrets (one of four exposed ferrets seroconverted without virus detection). Bovine HPAI H5N1 virus thus possesses features that may facilitate #infection and #transmission in #mammals.