#sialic — Public Fediverse posts

#Sialic acid-anchored #haemagglutinin stalk neutralizing #antibody M-SiaB enhances #protection against highly pathogenic #influenza #H5N1/Texas/2024, https://etidiohnew.blogspot.com/2026/06/sialic-acid-anchored-haemagglutinin.html

#Sialic acid-anchored #haemagglutinin stalk neutralizing #antibody M-SiaB enhances #protection against highly pathogenic #influenza #H5N1/Texas/2024, https://etidiohnew.blogspot.com/2026/06/sialic-acid-anchored-haemagglutinin.html

#H5N1 2.3.4.4b HA E190D and Q226H #mutations, picked up as minority #variants in a #patient, result in an inability to bind #sialic acid, https://etidiohnew.blogspot.com/2026/03/h5n1-2344b-ha-e190d-and-q226h-mutations.html

#H5N1 2.3.4.4b HA E190D and Q226H #mutations, picked up as minority #variants in a #patient, result in an inability to bind #sialic acid, https://etidiohnew.blogspot.com/2026/03/h5n1-2344b-ha-e190d-and-q226h-mutations.html

#Sialic acids are a #barrier to the entry of non-influenza #orthomyxoviruses, https://etidiohnew.blogspot.com/2026/01/sialic-acids-are-barrier-to-entry-of.html

#Sialic acids are a #barrier to the entry of non-influenza #orthomyxoviruses, https://etidiohnew.blogspot.com/2026/01/sialic-acids-are-barrier-to-entry-of.html

#Sialic Acid #Receptors in #Human Mammary Tissue: Implications for #Infection with Novel #Influenza Strains, https://etidiohnew.blogspot.com/2025/08/sialic-acid-receptors-in-human-mammary.html

#Sialic Acid #Receptors in #Human Mammary Tissue: Implications for #Infection with Novel #Influenza Strains, https://etidiohnew.blogspot.com/2025/08/sialic-acid-receptors-in-human-mammary.html

#Avian and #Human #Influenza A Virus #Receptors in #Bovine #Mammary #Gland, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/9/24-0696_article

An outbreak of influenza A (#H5N1) virus was detected in dairy cows in the #USA. We detected influenza A virus #sialic acid -α2,3/α2,6-galactose host receptors in bovine mammary glands by lectin histochemistry. Our results provide a rationale for the high levels of H5N1 virus in #milk from infected cows.

#Avian and #Human #Influenza A Virus #Receptors in #Bovine #Mammary #Gland, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/9/24-0696_article

An outbreak of influenza A (#H5N1) virus was detected in dairy cows in the #USA. We detected influenza A virus #sialic acid -α2,3/α2,6-galactose host receptors in bovine mammary glands by lectin histochemistry. Our results provide a rationale for the high levels of H5N1 virus in #milk from infected cows.

#Bovine #H5N1 #influenza virus binds poorly to #human-type #sialic acid #receptors, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.01.606177v1

Using two different methods, we found that both of the 2.3.4.4b H5s bound efficiently to glycan receptors with terminally linked a2-3 sialic acid with no detectable binding to glycan receptors with terminally linked a2-6 sialic acid.

#Bovine #H5N1 #influenza virus binds poorly to #human-type #sialic acid #receptors, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.01.606177v1

Using two different methods, we found that both of the 2.3.4.4b H5s bound efficiently to glycan receptors with terminally linked a2-3 sialic acid with no detectable binding to glycan receptors with terminally linked a2-6 sialic acid.

#Cell #binding, uptake and #infection of #influenza A virus using recombinant #antibody-based #receptors. http://biorxiv.org/cgi/content/short/2024.07.29.605726v1?rss=1

#Human and #avian influenza A viruses bind to #sialic acid (Sia) receptors on cells as their primary receptors, and this results in endocytic uptake of the virus.

#Cell #binding, uptake and #infection of #influenza A virus using recombinant #antibody-based #receptors. http://biorxiv.org/cgi/content/short/2024.07.29.605726v1?rss=1

#Human and #avian influenza A viruses bind to #sialic acid (Sia) receptors on cells as their primary receptors, and this results in endocytic uptake of the virus.

#H19 #influenza A virus exhibits #species-specific #MHC class II #receptor usage, Cell Host Microbe: https://www.cell.com/cell-host-microbe/abstract/S1931-3128(24)00190-2?rss=yes

Influenza A virus H19 subtype does not bind the canonical receptor #sialic acid. H19 utilizes MHC class II #proteins from distinct species for host cell entry.
Mutating the putative canonical RBS of H19 restores sialic acid dependency. Residues in the MHC class II α chain confer species-specific entry of H19.

#H19 #influenza A virus exhibits #species-specific #MHC class II #receptor usage, Cell Host Microbe: https://www.cell.com/cell-host-microbe/abstract/S1931-3128(24)00190-2?rss=yes

Influenza A virus H19 subtype does not bind the canonical receptor #sialic acid. H19 utilizes MHC class II #proteins from distinct species for host cell entry.
Mutating the putative canonical RBS of H19 restores sialic acid dependency. Residues in the MHC class II α chain confer species-specific entry of H19.

#Expert #reaction #study on features of #infection & #transmission of #bovine #H5N1 #influenza, Science Media Centre: https://www.sciencemediacentre.org/expert-reaction-study-on-features-of-infection-and-transmission-of-bovine-h5n1-influenza/

“There are some novel characteristics of this work compared with other studies, such as demonstrating ability of the virus to bind to both a2, 3 & a2,6 #sialic acid. This is of concern as it suggests a possible increase in potential of this virus to infect other mammals, including humans...

#Expert #reaction #study on features of #infection & #transmission of #bovine #H5N1 #influenza, Science Media Centre: https://www.sciencemediacentre.org/expert-reaction-study-on-features-of-infection-and-transmission-of-bovine-h5n1-influenza/

“There are some novel characteristics of this work compared with other studies, such as demonstrating ability of the virus to bind to both a2, 3 & a2,6 #sialic acid. This is of concern as it suggests a possible increase in potential of this virus to infect other mammals, including humans...

#Pathogenicity and #transmissibility of #bovine #H5N1 #influenza virus, Nature: https://www.nature.com/articles/s41586-024-07766-6

Importantly, bovine HPAI H5N1 virus bound to #sialic acids expressed in #human upper #airways and inefficiently transmitted to exposed ferrets (one of four exposed ferrets seroconverted without virus detection). Bovine HPAI H5N1 virus thus possesses features that may facilitate #infection and #transmission in #mammals.

#Pathogenicity and #transmissibility of #bovine #H5N1 #influenza virus, Nature: https://www.nature.com/articles/s41586-024-07766-6

Importantly, bovine HPAI H5N1 virus bound to #sialic acids expressed in #human upper #airways and inefficiently transmitted to exposed ferrets (one of four exposed ferrets seroconverted without virus detection). Bovine HPAI H5N1 virus thus possesses features that may facilitate #infection and #transmission in #mammals.

Comprehensive #Molecular #Epidemiology of #Influenza Viruses in #Brazil: Insights from a Nationwide Analysis, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.07.04.602044v1

For #H1N1pdm09, 2022 consensus of 5a.2a.1 & #vaccine strain A/Victoria/2570/2019 had 14 amino acid #substitutions. Key residues such as H180, D187, K219, R223, E224, & T133 are involved in hydrogen interactions with #sialic acids, while N130, K142, and D222 may influence distance interactions based on docking analyses.

Comprehensive #Molecular #Epidemiology of #Influenza Viruses in #Brazil: Insights from a Nationwide Analysis, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.07.04.602044v1

For #H1N1pdm09, 2022 consensus of 5a.2a.1 & #vaccine strain A/Victoria/2570/2019 had 14 amino acid #substitutions. Key residues such as H180, D187, K219, R223, E224, & T133 are involved in hydrogen interactions with #sialic acids, while N130, K142, and D222 may influence distance interactions based on docking analyses.

#Sialic #Acid #Receptor Specificity in #Mammary #Gland of Dairy #Cattle Infected with Highly Pathogenic Avian #Influenza A(#H5N1) Virus, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/7/24-0689_article

Mammary gland tissues co-stained with sialic acids and influenza A virus #nucleoprotein showed predominant co-localization with the virus and SA α2,3-gal. HPAI H5N1 exhibited epitheliotropism within the mammary gland, and we observed rare immunolabeling within macrophages.

#Sialic #Acid #Receptor Specificity in #Mammary #Gland of Dairy #Cattle Infected with Highly Pathogenic Avian #Influenza A(#H5N1) Virus, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/7/24-0689_article

Mammary gland tissues co-stained with sialic acids and influenza A virus #nucleoprotein showed predominant co-localization with the virus and SA α2,3-gal. HPAI H5N1 exhibited epitheliotropism within the mammary gland, and we observed rare immunolabeling within macrophages.

The mammary #glands of #cows abundantly display #receptors for circulating avian #H5 viruses, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.05.24.595667v2

Most of the #sialome of the cow and #goat respiratory tract is lined with #sialic acid modifications such as N-glycolyl and O-acetyl, such structures are not bound by IAV.

The mammary #glands of #cows abundantly display #receptors for circulating avian #H5 viruses, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.05.24.595667v2

Most of the #sialome of the cow and #goat respiratory tract is lined with #sialic acid modifications such as N-glycolyl and O-acetyl, such structures are not bound by IAV.

The #avian and #human #influenza A virus #receptors #sialic acid (SA)-α2,3 and SA-α2,6 are widely expressed in the #bovine #mammary #gland, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.05.03.592326v1?rss=1

IAVs isolated from chickens generally bind more tightly to SA-α2,3-Gal-β1,4 (chicken receptor), whereas IAVs isolated from duck to SA-α2,3-Gal-β1,3 (duck receptor). We found all receptors were expressed, to a different degree, in the mammary gland, respiratory tract, and cerebrum of beef and/or dairy cattle.

The #avian and #human #influenza A virus #receptors #sialic acid (SA)-α2,3 and SA-α2,6 are widely expressed in the #bovine #mammary #gland, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.05.03.592326v1?rss=1

IAVs isolated from chickens generally bind more tightly to SA-α2,3-Gal-β1,4 (chicken receptor), whereas IAVs isolated from duck to SA-α2,3-Gal-β1,3 (duck receptor). We found all receptors were expressed, to a different degree, in the mammary gland, respiratory tract, and cerebrum of beef and/or dairy cattle.