#receptors — Public Fediverse posts

Scientists create first detailed smell map

Scientists in America have created the first detailed map of the smell receptors in the nose. The study…
#NewsBeep #News #Science #AU #Australia #mice #Nose #odours #receptors #senseofsmell #smell
https://www.newsbeep.com/au/674533/

#Bovine #H5N1 #influenza viruses have adapted to more efficiently use #receptors abundant in #cattle, https://etidiohnew.blogspot.com/2026/04/bovine-h5n1-influenza-viruses-have.html

News from Leibniz research: #Bitter #Taste #Receptors at the Interface Between #Nutrition, the #Endocrine System, and #Health https://www.leibniz-lsb.de/en/press-public-relations/translate-to-englisch-pm-20260128-pressemitteilung-bittergeschmacksrezeptoren-ernaehrung-hormonsystem-gesundheit
https://nachrichten.idw-online.de/2026/01/28/bitter-taste-receptors-at-the-interface-between-nutrition-the-endocrine-system-and-health

#RaphaelMechoulam, the father of 🌱 #cannabis #research, passed away on March 10, 2023, at 92 years of age. In early 1960, he was the first to reveal the structure of #cannabidiol (#CBD) and delta 9-#tetrahydrocannabinol (#THC), molecules now used worldwide as #medicine.1,2 In addition, Professor #Mechoulam and his research group identified the #endocannabinoidsystem, a #biologicalsystem with #endogenous #neurotransmitters that bind to specific #receptors ... https://pmc.ncbi.nlm.nih.gov/articles/PMC10288473/

https://www.europesays.com/ie/196799/ Fusobacterium nucleatum-reprogrammed adipocytes promote tumor cisplatin resistance through the CCL2-CCR2 axis in the necrotic metastatic neck nodes of head and neck carcinoma | Cell Communication and Signaling #Adipocyte #CCL2 #CellBiology #Cisplatin #CytokinesAndGrowthFactors #Éire #FusobacteriumNucleatum #HeadAndNeckCarcinoma #Health #IE #Ireland #ProteinLigandInteractions #Receptors

16-Sep-2025
Better understanding of #bitter #taste receptors: An AlphaFold3-based structure study
Researchers use an advanced AI-based prediction model, #AlphaFold 3, to predict the structure of human bitter taste #receptors
https://www.eurekalert.org/news-releases/1098406

#science #humans #physiology #proteinstructure

#H3N2 #influenza virus #tropism shifts to glycan #receptors on tracheal ciliated cells, https://etidiohnew.blogspot.com/2025/09/h3n2-influenza-virus-tropism-shifts-to.html

#Sialic Acid #Receptors in #Human Mammary Tissue: Implications for #Infection with Novel #Influenza Strains, https://etidiohnew.blogspot.com/2025/08/sialic-acid-receptors-in-human-mammary.html

https://www.europesays.com/uk/306699/ FDA Seeks Schedule I Status for ‘Legal Morphine’ #Abuse #addiction #brain #ChronicPain #DataCollection #epidemic #Health #heel #Medication #opioids #PainManagement #psychoactive #psychotropic #receptors #smoker #Smoking #TobaccoCessation;QuittingTobaccoUse;SmokingCessation #Toxicology;Toxicity;Poisoning;Toxins #U.S.FoodAndDrugAdministration;UnitedStatesFoodAndDrugAdministration;FDA;FoodAndDrugAdministration(FDA);FoodAndDrugAdministration #UK #UnitedKingdom

https://www.europesays.com/uk/300058/ Most GLP-1 Prescriptions Miss the Mark: Are Yours? #BariatricSurgery;ObesitySurgery;WeightLossSurgery #dehydration #GLP1ReceptorAgonists #GlucagonLikePeptide1ReceptorAgonists #Health #hypohydration #imbalance #Medication #muscles #Obesity;Obese #receptors #Type2DiabetesMellitus;DiabetesMellitusType2;DiabetesMellitusTypeII;Type2Diabetes;Type2DM;T2DM;T2D;Type2DiabetesMellitus(T2DM);Type2Diabetes(T2D) #UK #UnitedKingdom #WeightLoss #WeightManagement

HKU5 #bat #merbecoviruses engage bat and #mink #ACE2 as entry #receptors, https://etidiohnew.blogspot.com/2025/07/hku5-bat-merbecoviruses-engage-bat-and.html

Pregnant Dairy #Heifers Express #Influenza A Virus #Receptors in the Mammary #Gland, https://etidiohnew.blogspot.com/2025/05/pregnant-dairy-heifers-express.html

#Bovine #H5N1 binds poorly to #human-type sialic acid #receptors, https://etidiohnew.blogspot.com/2025/04/bovine-h5n1-binds-poorly-to-human-type.html

The Q226L #mutation can convert a highly pathogenic #H5 2.3.4.4e virus to bind #human-type #receptors, https://etidiohnew.blogspot.com/2025/04/the-q226l-mutation-can-convert-highly.html

Mushroom A.stiptica Bitter Compounds and Human Taste Receptor Activation

https://pubs.acs.org/doi/10.1021/acs.jafc.4c12651

#HackerNews #Mushrooms #Taste #Receptors #Bitter #Compounds #Human #Biology #Research

🫀 Sweet taste receptors in the heart: A new pathway for cardiac regulation

https://medicalxpress.com/news/2025-02-sweet-receptors-heart-pathway-cardiac.html

#heart #cardiology #biology #sweetness #receptors

''all five isolates harbored HA #markers (226Q and 228G), suggesting more efficient #binding to avian receptors than to human #receptors, while all five strains had amino acid #substitutions that included 133A and 156A which might increase binding affinity to human-like receptors''

The Q226L #mutation can convert a highly pathogenic #H5 2.3.4.4e virus to #bind #human-type #receptors, https://etidiohnew.blogspot.com/2025/01/the-q226l-mutation-can-convert-highly.html

The two #systemin #peptide #receptors in tomatoes have opposite functions. While SYR1 activates systemin-induced #immune responses, SYR2 acts as an antagonist. Wounding preferentially induces the expression of SYR2 that attenuates immune responses by outcompeting SYR1 for binding with the co-receptor SERK3a

https://www.cell.com/action/showPdf?pii=S1534-5807%2824%2900670-1

#PlantScience #PlantImmunity #Tomato

A single #mutation in #bovine #influenza #H5N1 #hemagglutinin switches specificity to #human #receptors

Source: Science, Editor’s summary In 2021, a highly pathogenic influenza H5N1 clade 2.3.4.4b virus was detected in North America that is capable of infecting a diversity of avian species, marine mammals, and humans. In 2024, clade 2.3.4.4b virus spread widely in dairy cattle in the US, causing a few mild human cases, but retaining specificity for avian receptors…

https://etidioh.wordpress.com/2024/12/06/a-single-mutation-in-bovine-influenza-h5n1-hemagglutinin-switches-specificity-to-human-receptors/

Pictures of AMPA receptors at synapses from Axel Brunger's lab. By averaging a lot of tomogram images, they could discern scaffolding molecules bound to the complexes.

These in situ images are lower resolution than purified protein, but retain the native organization and place the receptors somewhat at the side of vesicular docking sites.

https://www.biorxiv.org/content/10.1101/2024.10.19.619226v2

#synapses #neuroscience #CellularStructuralBiology #Receptors

The #mammary #glands of #cows abundantly display #receptors for circulating #avian #H5 viruses

Source: Journal of Virology, ABSTRACTInfluenza A viruses (IAVs) from the H5N1 2.3.4.4b clade are circulating in dairy farms in the USA.; ruminants were presumed not to be hosts for IAVs. Previously, IAV-positive mammalian species were hunters and scavengers, possibly getting infected while feeding on infected birds. It is now recognized that H5N1 viruses that circulate in US…

https://etidioh.wordpress.com/2024/10/10/the-mammary-glands-of-cows-abundantly-display-receptors-for-circulating-avian-h5-viruses/

"It seemed possible that the time course of the events might come well within the practical range of this method, and the results described in this paper have borne out this expectation."

Katz describing iontophoretic application of neurotransmitter to induce "inactive" desensitized states of a receptor in

A STUDY OF THE 'DESENSITIZATION' PRODUCED BY ACETYLCHOLINE AT THE MOTOR END-PLATE
Katz and Thesleff, 1957

https://doi.org/10.1113/jphysiol.1957.sp005838

#biophysics #receptors #physiology #neuroscience

#Avian and #Human #Influenza A Virus #Receptors in #Bovine #Mammary #Gland, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/9/24-0696_article

An outbreak of influenza A (#H5N1) virus was detected in dairy cows in the #USA. We detected influenza A virus #sialic acid -α2,3/α2,6-galactose host receptors in bovine mammary glands by lectin histochemistry. Our results provide a rationale for the high levels of H5N1 virus in #milk from infected cows.

#Bovine #H5N1 #influenza virus binds poorly to #human-type #sialic acid #receptors, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.01.606177v1

Using two different methods, we found that both of the 2.3.4.4b H5s bound efficiently to glycan receptors with terminally linked a2-3 sialic acid with no detectable binding to glycan receptors with terminally linked a2-6 sialic acid.

#Receptor #Binding Specificity of a #Bovine #H5N1 #Influenza Virus, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.07.30.605893v1

We found that A/bovine/OH/B24OSU-432/2024 preferentially binds to #avian type #receptors (alpha2,3-sialosides). Sequence alignments showed that A/bovine has maintained aa in its HA associated with alpha2,3-sialoside (avian) specificity. We conclude that while we find no evidence that A/bovine has acquired human virus RB specificity, ongoing efforts must be placed on monitoring for this trait.

#Cell #binding, uptake and #infection of #influenza A virus using recombinant #antibody-based #receptors. http://biorxiv.org/cgi/content/short/2024.07.29.605726v1?rss=1

#Human and #avian influenza A viruses bind to #sialic acid (Sia) receptors on cells as their primary receptors, and this results in endocytic uptake of the virus.

#Haemagglutinin #Genes of #UK Clade 2.3.4.4b #H5N1 Avian #Influenza Viruses from 2020-22 Retain Strong Avian #Phenotype, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.07.09.602706v1

We evaluated a comprehensive panel of H5 viruses representing prevalent genotypes from UK outbreaks spanning 2020-22 for HA functionality. Viruses only bound to avian #receptors & exhibited fusion at a pH of 5.8, above pH range (pH 5.0 to 5.5) associated w/ efficient h2h transmission. These H5 viruses have low immediate zoonotic threat.

Technical #Report: Highly Pathogenic Avian #Influenza A(#H5N1) Viruses, #US #CDC, June 5 2024 Update: https://www.cdc.gov/flu/avianflu/spotlights/2023-2024/h5n1-technical-report-06052024.htm

Clade 2.3.4.4b HPAI A(H5N1) viruses currently circulating in wild #birds and #poultry worldwide lack the ability to preferentially bind to the types of sialic acid #receptors that are predominant in the upper respiratory tract of #humans and therefore do not currently have the ability to easily infect or transmit among people.

The mammary #glands of #cows abundantly display #receptors for circulating avian #H5 viruses, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.05.24.595667v2

Most of the #sialome of the cow and #goat respiratory tract is lined with #sialic acid modifications such as N-glycolyl and O-acetyl, such structures are not bound by IAV.

The #avian and #human #influenza A virus #receptors #sialic acid (SA)-α2,3 and SA-α2,6 are widely expressed in the #bovine #mammary #gland, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.05.03.592326v1?rss=1

IAVs isolated from chickens generally bind more tightly to SA-α2,3-Gal-β1,4 (chicken receptor), whereas IAVs isolated from duck to SA-α2,3-Gal-β1,3 (duck receptor). We found all receptors were expressed, to a different degree, in the mammary gland, respiratory tract, and cerebrum of beef and/or dairy cattle.

Very interesting structures of the GluN1/N3 variant NMDA receptor from Michalski and Furukawa. Unprecedented 80º rotation of the GluN3 subunit into a desensitised conformation, which could be disrupted by mutation.

#biophysics #receptors #neuroscience

https://www.science.org/doi/pdf/10.1126/sciadv.adl5952

#Evolution of #H7N9 highly pathogenic avian #influenza virus in the context of #vaccination, https://doi.org/10.1080/22221751.2024.2343912

... H7N9 viruses detected in this study exclusively bound to the #avian-type #receptors, having lost the capacity to bind to #human-type receptors. Our study shows that vaccination slows the evolution of H7N9 virus by preventing its reassortment with other viruses and eliminates a harmful characteristic of H7N9 virus, namely its ability to bind to human-type receptors.

#Translocons...what can we say? It's a process!
In a new #OpenAccess #JIPB paper, Yang et al. report on a converged ubiquitin-proteasome pathway for the degradation of TOC & TOM tail-anchored #receptors.
https://doi.org/10.1111/jipb.13645
@wileyplantsci
#PlantSci #chloroplast #mitochondrion #botany

Two sex #pheromone receptors for sexual communication found in the American #cockroach.

#periplanone #signalling #olfaction #receptors #OR53 #OR100

https://phys.org/news/2024-04-sex-pheromone-receptors-sexual-communication.html

#Avian #H6 #Influenza Viruses in #Vietnamese Live #Bird #Markets during 2018-2021 https://pubmed.ncbi.nlm.nih.gov/38543733/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240328065908&v=2.18.0.post9+e462414

The Vietnamese H6 viruses analyzed here possess an #aminoacid motif in #HA that confers #binding to both avian- and human-type #receptors on host cells, consistent with their ability to infect #mammals.

How #insects tell different #sugars apart.

#sensing #taste #receptors

https://phys.org/news/2024-03-insects-sugars.html

#Genetic Characterization and #Phylogeographic Analysis of the First #H13N6 Avian #Influenza Virus Isolated from Vega #Gull in South #Korea https://pubmed.ncbi.nlm.nih.gov/38400060/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240224132335&v=2.18.0.post9+e462414

-- various point amino acid #mutations were found on all gene #segments, and some are linked to an increased #binding to #human-type #receptors, resistance to #antivirals, and virulence.

https://nitter.1d4.us/DanielKronauer/status/1733151774138048807

https://www.sciencedirect.com/science/article/pii/S0960982223015397

#Ants use a “new” mechanism to regulate gene expression at large tandem arrays of #odorant #receptors. #Neurons “choose” a transcription start site along the array, and then express all downstream genes. To fine-tune receptor expression in the neurons, only RNA from the most upstream expressed gene is exported into the cytoplasm to be translated. This suggests that, despite #coexpression, ant #olfactory neurons ultimately make only one receptor.

More weird stuff with Delta type #glutamate #receptors - GABA binding and a non-iontropic plasticity at inhibitory #synapses from the GluD1 subtype.

https://www.science.org/doi/10.1126/science.adf3406

Airklipz ft. Edward Splifforhands – Receptors [Video]

Taken from the Vape Life 6 LP by Airklipz we have Receptors which features Edward Splifforhands, as do all the tracks on the LP. The track refers to the cannabinoid receptors and rejoices the use of Marijuana as well as the favourite topic of vaping.

#Airklipz #EdwardSplifforhands #JammyGit #Receptors #VapeLife6

https://www.britishhiphop.co.uk/downloads/video/airklipz-ft-edward-splifforhands-receptors-video.html

@martinvoegele great results - this is very impressive. Huge win for structural and #ComputationalBiology of #receptors, showing a reliable relation between free energy of binding across functional states (resting/active) and ligand activity. Drug action on GPCRs can be classified in the computer. #biophysics #pharmacology #drugdesign

https://pubs.acs.org/doi/10.1021/acs.jctc.3c00899

Photoswitchable NMDA inhibition - from recombinant receptors to blocking tadpole locomotion. Nice work from Laetitia Mony and Pierre Paoletti.

#neuroscience #ionchannels #receptors

https://www.biorxiv.org/content/10.1101/2023.10.16.562518v2.abstract

Always been curious how different interferons that signal through same receptor can have different functional effect. Here's a paper that shows how:
#interferon #immunology #receptor #receptors #Signalling https://www.science.org/doi/10.1126/scisignal.adf5494

A new perspective in #protein research focuses on #disordered areas.

#membrane_channels #receptors

https://phys.org/news/2023-07-perspective-protein-focuses-disordered-areas.html

An international team of researchers, studying macaque #brains, have mapped out #neurotransmitter #receptors, revealing a potential role in distinguishing internal #thoughts and #emotions from those generated by external influences.
#Neuroscience #sflorg
https://www.sflorg.com/2023/06/ns0619230.html

#Scientists at St. Jude Children’s Research Hospital added a #molecular anchor to #chimeric #antigen #receptors (#CARs), increasing the anti-cancer activity of cellular #immunotherapies in #cancer models.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/02/bio02052305.html