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#orf8 — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #orf8, aggregated by home.social.

  1. Giuseppe Michieli @[email protected] ·

    Positive #selection underlies repeated knockout of #ORF8 in #SARS-CoV-2 #evolution nature.com/articles/s41467-024

    SARS-CoV-2 constantly evolves but the roles of resulting #mutations are not always clear. In this study, the authors report that ORF8 knockout confers a #fitness advantage to SARS-CoV-2 using genomic #surveillance data, highlighting how different types of adaptations across the SARS-CoV-2 genome can drive variant fitness.

    #selection #orf8 #sars #evolution #mutations #fitness
  2. Giuseppe Michieli @[email protected] ·

    Positive #selection underlies repeated knockout of #ORF8 in #SARS-CoV-2 #evolution nature.com/articles/s41467-024

    SARS-CoV-2 constantly evolves but the roles of resulting #mutations are not always clear. In this study, the authors report that ORF8 knockout confers a #fitness advantage to SARS-CoV-2 using genomic #surveillance data, highlighting how different types of adaptations across the SARS-CoV-2 genome can drive variant fitness.

    #selection #orf8 #sars #evolution #mutations #fitness
  3. Giuseppe Michieli @[email protected] ·

    Positive #selection underlies repeated knockout of #ORF8 in #SARS-CoV-2 #evolution nature.com/articles/s41467-024

    SARS-CoV-2 constantly evolves but the roles of resulting #mutations are not always clear. In this study, the authors report that ORF8 knockout confers a #fitness advantage to SARS-CoV-2 using genomic #surveillance data, highlighting how different types of adaptations across the SARS-CoV-2 genome can drive variant fitness.

    #selection #orf8 #sars #evolution #mutations #fitness
  4. Giuseppe Michieli @[email protected] ·

    Positive #selection underlies repeated knockout of #ORF8 in #SARS-CoV-2 #evolution nature.com/articles/s41467-024

    SARS-CoV-2 constantly evolves but the roles of resulting #mutations are not always clear. In this study, the authors report that ORF8 knockout confers a #fitness advantage to SARS-CoV-2 using genomic #surveillance data, highlighting how different types of adaptations across the SARS-CoV-2 genome can drive variant fitness.

    #surveillance #fitness #mutations #evolution #sars #orf8
  5. Giuseppe Michieli @[email protected] ·

    Positive #selection underlies repeated knockout of #ORF8 in #SARS-CoV-2 #evolution nature.com/articles/s41467-024

    SARS-CoV-2 constantly evolves but the roles of resulting #mutations are not always clear. In this study, the authors report that ORF8 knockout confers a #fitness advantage to SARS-CoV-2 using genomic #surveillance data, highlighting how different types of adaptations across the SARS-CoV-2 genome can drive variant fitness.

    #selection #orf8 #sars #evolution #mutations #fitness
  6. Giuseppe Michieli @[email protected] ·

    #Virological characteristics of the #SARS-CoV-2 #Omicron #XBB15 #variant, Nat Commun.: nature.com/articles/s41467-024

    -- We provide intrinsic pathogenicity of XBB.1 & XBB.1.5 in hamsters. ...we find that #ORF8 nonsense mutation of XBB.1.5 resulted in impairment of #MHC suppression. In vivo experiments using recombinant viruses reveal that XBB.1.5 mutations are involved with reduced virulence of XBB.1.5... our study identifies 2 viral functions defined difference between XBB.1 & XBB.1.5.

    #virological #sars #omicron #xbb15 #variant #orf8
  7. Giuseppe Michieli @[email protected] ·

    #Virological characteristics of the #SARS-CoV-2 #Omicron #XBB15 #variant, Nat Commun.: nature.com/articles/s41467-024

    -- We provide intrinsic pathogenicity of XBB.1 & XBB.1.5 in hamsters. ...we find that #ORF8 nonsense mutation of XBB.1.5 resulted in impairment of #MHC suppression. In vivo experiments using recombinant viruses reveal that XBB.1.5 mutations are involved with reduced virulence of XBB.1.5... our study identifies 2 viral functions defined difference between XBB.1 & XBB.1.5.

    #virological #sars #omicron #xbb15 #variant #orf8
  8. Giuseppe Michieli @[email protected] ·

    #Virological characteristics of the #SARS-CoV-2 #Omicron #XBB15 #variant, Nat Commun.: nature.com/articles/s41467-024

    -- We provide intrinsic pathogenicity of XBB.1 & XBB.1.5 in hamsters. ...we find that #ORF8 nonsense mutation of XBB.1.5 resulted in impairment of #MHC suppression. In vivo experiments using recombinant viruses reveal that XBB.1.5 mutations are involved with reduced virulence of XBB.1.5... our study identifies 2 viral functions defined difference between XBB.1 & XBB.1.5.

    #virological #sars #omicron #xbb15 #variant #orf8
  9. Giuseppe Michieli @[email protected] ·

    #Virological characteristics of the #SARS-CoV-2 #Omicron #XBB15 #variant, Nat Commun.: nature.com/articles/s41467-024

    -- We provide intrinsic pathogenicity of XBB.1 & XBB.1.5 in hamsters. ...we find that #ORF8 nonsense mutation of XBB.1.5 resulted in impairment of #MHC suppression. In vivo experiments using recombinant viruses reveal that XBB.1.5 mutations are involved with reduced virulence of XBB.1.5... our study identifies 2 viral functions defined difference between XBB.1 & XBB.1.5.

    #mhc #orf8 #variant #xbb15 #omicron #sars
  10. Giuseppe Michieli @[email protected] ·

    #Virological characteristics of the #SARS-CoV-2 #Omicron #XBB15 #variant, Nat Commun.: nature.com/articles/s41467-024

    -- We provide intrinsic pathogenicity of XBB.1 & XBB.1.5 in hamsters. ...we find that #ORF8 nonsense mutation of XBB.1.5 resulted in impairment of #MHC suppression. In vivo experiments using recombinant viruses reveal that XBB.1.5 mutations are involved with reduced virulence of XBB.1.5... our study identifies 2 viral functions defined difference between XBB.1 & XBB.1.5.

    #virological #sars #omicron #xbb15 #variant #orf8
  11. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    A quick tweetorial from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain
    #ORF8 #AccessoryProtein #COVID19

    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virologic…
    twitter.com/PeacockFlu/status/

    #covid19 #accessoryprotein #orf8 #sarscov2
  12. Raj Rajnarayanan :verified: @tRAJectory ·

    is missing a piece and it doesn't even care

    A quick tweetorial from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain

    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virologic…
    twitter.com/PeacockFlu/status/

    #sarscov2 #orf8 #accessoryprotein #covid19
  13. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    A quick tweetorial from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain
    #ORF8 #AccessoryProtein #COVID19

    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virologic…
    twitter.com/PeacockFlu/status/

    #covid19 #accessoryprotein #orf8 #sarscov2
  14. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    A quick tweetorial from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain
    #ORF8 #AccessoryProtein #COVID19

    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virologic…
    twitter.com/PeacockFlu/status/

    #sarscov2 #orf8 #accessoryprotein #covid19
  15. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    A quick tweetorial from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain
    #ORF8 #AccessoryProtein #COVID19

    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virologic…
    twitter.com/PeacockFlu/status/

    #covid19 #accessoryprotein #orf8 #sarscov2
  16. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    Tweetsplainer from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain

    #ORF8 #AccessoryProtein #COVID19
    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virological_o…
    twitter.com/PeacockFlu/status/

    #covid19 #accessoryprotein #orf8 #sarscov2
  17. Raj Rajnarayanan :verified: @tRAJectory ·

    is missing a piece and it doesn't even care

    Tweetsplainer from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain


    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virological_o…
    twitter.com/PeacockFlu/status/

    #sarscov2 #orf8 #accessoryprotein #covid19
  18. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    Tweetsplainer from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain

    #ORF8 #AccessoryProtein #COVID19
    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virological_o…
    twitter.com/PeacockFlu/status/

    #covid19 #accessoryprotein #orf8 #sarscov2
  19. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    Tweetsplainer from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain

    #ORF8 #AccessoryProtein #COVID19
    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virological_o…
    twitter.com/PeacockFlu/status/

    #sarscov2 #orf8 #accessoryprotein #covid19
  20. Raj Rajnarayanan :verified: @[email protected] ·

    #SARSCoV2 is missing a piece and it doesn't even care

    Tweetsplainer from @PeacockFlu

    H/T @siamosolocani @LongDesertTrain

    #ORF8 #AccessoryProtein #COVID19
    ---
    RT @PeacockFlu
    Inspired by some recent discussion we wrote a short report for virological about how one of SARS-CoV-2's accessory proteins (called ORF8) appears to have gone missing over the last year (with @LongDesertTrain and @siamosolocani) twitter.com/virological_o…
    twitter.com/PeacockFlu/status/

    #covid19 #accessoryprotein #orf8 #sarscov2
  21. Giuseppe Michieli @[email protected] ·

    Unconventional #secretion of unglycosylated #ORF8 is critical for the #cytokine #storm during #SARS-CoV-2 infection journals.plos.org/plospathogen

    #sars #storm #cytokine #orf8 #secretion