#epigenomics22 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #epigenomics22, aggregated by home.social.
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Another talk about long reads: Duncan Sproul on Genome-wide analysis of single-molecule DNA methylation
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Last day: Ariel Gershman from Johns Hopkins reminding us that hg38 is still far from a "finished" assembly of the human genome, which has implication for epigenetics, too
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Elad Segev: Discontinuities aging: finding switch points in DNA methylation
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Andrew Teschendorff on "Cell-type deconvolution of solid tissue DNA methylomes at cell-type resolution" - this one is quite close to my heart, as we're working on similar stuff 😉
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Martin Hirst - EpiATLAS, a reference for epigenetic research
Useful resource: IHEC - the International Human Epigenome Consortium
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Rama Natarajan now talking about Epigenetics and noncoding RNAs in #diabetes
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CW: conference live toot epigenomics
B-cell involvement in MS: EBV latent in MS B-Cells, alterations to the epigenome (predominant hypomethylation) ➡️ Age associated B-cells?
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CW: conference live toot epigenomics
methylation differences distinguish risk groups of MS progression. Searching for genetic predisposition conditional on DNAm revealed HLA differences between progressing and non-progressing groups #Epigenomics22 #epigenetics
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First up: Maja Jagodic from Karolinska Institute talking about mechanisms of Multiple Sclerosis development and progression
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Not sure how interested anyone in my network is in my live-tooting of talks from the #Epigenomics of Common Disease 2022 conference? Anyway, I'll keep going for now 🙃
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Sonia Garcia-Calzon - Novel subgroups of type 2 #diabetes reveal different DNA methylation patterns:
adipose tissue methylation changes distinguish subtypes, and some of these are detectable also in blood. Also predict future risk of complications.
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Short talks now: Marie de Borre on cfDNA detection of
#preeclempsia using methylation changes. Use CpG sites with placenta-specific methyl. as markers. Early detection before usual diagnosis has high AUC #Epigenomics22 #epigenetics -
CW: conference live toot epigenomics
"spatial multi-omic heart atlas": link spatial transcriptomics with single-cell RNA and epigenetics. Also sampling over multiple timepoints including accute myocardial infarction.
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Next: Christoph Kuppe from Aachen talking about Spatial and single cell multi-omic analysis of human heart disease
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CW: conference live toot epigenomics
Regulation of ZBTB16 prob directly regulated by gccs through altering methylation levels around gcc response element in the enhancer. #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
in-vitro stimulation of brain organoids with glucocorticoids shows upregulation of ZBTB16. KO of that gene blocks some effects of gccs #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
Glucocorticoid response elements GREs show demethylation upon increased transcriptional response. Priming during pregnancy? #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
Glucocorticoids given during pregnancy or as a result of stress can impact epigenetic marks in offspring - epigenetic "memory"?
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Back after the coffee break. Now:
"Cerebral organoids and prenatal stress"
by Elizabeth Binder from the Max Planck Institute of Psychiatry in Munich #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
post-birth methylation changes reveals non-age-related differentially methylated regions related to autism and schizophrenia genes #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
Methylation important during development of the brain and in psychiatric disease. But: little data for childhood/adult comparison and cell-type specific effects #Epigenomics22 #epigenetics
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Now: Alice Franklin from Exeter: Developmental trajectories of DNA methylation during brain development #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
Changes also associate with lean mass in offspring #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
obesity during pregnancy: check effect of dietary intervention during pregnancy. Lifestyle intervention affectrs DNA meth in several hundred CpGs
#Epigenomics22 #epigenetics -
Short talks now: 1st Josefine Jönsson, Lund University, Sweden:
Lifestyle intervention during pregnancy alters DNA methylation in offspring cord blood
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CW: conference live toot epigenomics
High-fat diet re-activates an otherwise silenced imprinted promoter in the F1 #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
Created reporter mice that express a reporter under a maternal or paternal imprinted promoter. Resource for the comunity, available through the MRC/LMS
#Epigenomics22 #epigenetics -
CW: conference live toot epigenomics
Imprinted genes do not follow the same demethylation dynamics as most other genes and can thus be used as a reference for early-develomental environmental effects #Epigenomics22 #epigenetics
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Mathew Van de Pette talking about Epigenetic changes induced by environmental exposures #Epigenomics22 #epigenetics
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CW: conference live toot epigenomics
Olduvai domain, characterised by copy-number increase in modern humans and linked to brain development, has predicted methylation differences in archaic humans. Differential regulation? #Epigenomics22 #epigenetics