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#spatial_omics — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #spatial_omics, aggregated by home.social.

  1. Working with Visium data deconvolved via cell2location. Need to calculate gene signature scores but cell type layers have different scales (Ductal: 0-37 vs Malignant: 0-228). Best approach? 1) Global score 2) Cell-type-specific 3) Weighted by abundance. Leaning toward option 3 but concerned about comparability across spots. Scale differences make normalization tricky. Anyone implemented signature scoring on cell2location results? #spatial_omics