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#orglett — Public Fediverse posts

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  1. Stephan @[email protected] ·

    I am happy to share my recent publication in #OrgLett 📰

    ⚗️ We synthesized carbobicyclic nucleoside analogues which appear to be potent #antivirals against #RSV Despite their novel bicyclic structure, they adopt a ribose-like structure. This may be a new template for novel nucleoside analogues.

    pubs.acs.org/doi/10.1021/acs.o

    ➡️ Next step: Explore the mechanism of action.

    #chemistry #medchem #virus #science #research #CUHK #HongKong

    #hongkong #cuhk #research #science #virus #medchem
  2. Chemistry Research @[email protected] ·

    Carbasugar #nucleoside analogues often lack biological activity, which is attributed to an unfavorable conformation. Locked nucleoside analogues, however, can mantain the ribose-like conformation. Another synthetic access is published in #OrgLett by Lak Shin Joeng and colleagues from Seoul National University (S. #Korea)

    They were able to report the synthesis of the conformationally locked cytidine nucleoside analogue in 19 steps.

    #chemistry #MedChem @chemistry
    pubs.acs.org/doi/10.1021/acs.o

    #medchem #chemistry #korea #orglett #nucleoside