#mushroombody — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #mushroombody, aggregated by home.social.
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Ron Tanimoto's lab characterizes synaptic diversity in the center for learning and memory in the #Drosophila brain, the mushroom bodies, using light microscopy techniques to label Bruchpilot (Brp), a presynaptic scaffold protein.
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Synapses in the fly brain learning and memory centre, the mushroom body:
"Quantitative characterization of the pattern of Brp clusters across multiple individuals revealed cell-type-dependent synapse heterogeneity and stereotypy. Furthermore, we discovered previously unidentified sub-compartmental synapse configuration and its regulation by cAMP signaling."
From:
"High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain", by Wu et al. (Tanimoto lab) 2025
https://www.biorxiv.org/content/10.1101/2024.12.02.626511v4 -
What is the role of #epigenetic mechanisms in long-lived post-mitotic #neurons? This study shows that the histone methyltransferase Trithorax regulates the metabolic state of #MushroomBody neurons and is necessary for long term #memory formation in #Drosophila #plosbiology https://plos.io/3PWaksa
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"Driver lines for studying associative learning in Drosophila" by Shuai, Sammons et al. 2024 (Yoshi Aso's lab).
https://elifesciences.org/reviewed-preprints/94168 -
"Flexible specificity of memory in Drosophila depends on a comparison between choices", by Modi et al. 2023 (Glenn Turner's lab) https://elifesciences.org/articles/80923
"A memory too specific will be useless in even a slightly different environment, while an overly general memory may lead to suboptimal choices."
"Rather than forming memories that strike a balance between specificity and generality, Drosophila can flexibly categorize a given stimulus into different groups depending on the options available."
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"Hacking brain development to test models of sensory coding"
Ahmed et al. 2023 (Clowney lab)"we develop methods to increase and decrease Kenyon cell claw number and therefore the number of olfactory inputs that individual Kenyon cells receive."
(claws are the inputs from projection neurons (PNs), and Kenyon cells are like granular cells in the cerebellum.)
"We then use these circuit-hacked animals to test the effects of altering Kenyon cell number and claw number on sensory representations and associative learning behavior. We find that changing Kenyon cell number only modestly affects population-level odor responses. In contrast, Kenyon cell odor responses change bidirectionally as we change Kenyon cell dendritic claw number, such that Kenyon cells become less odor-selective as their input number grows."
"Remarkably, animals with reduced Kenyon cell population size can learn simple olfactory associations, and animals with augmented sets of Kenyon cells show improved associative learning."
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Wow Scott—the abstract alone is like a mini neuroscience conference on learning and memory. Looking forward to reading it slowly.
Meanwhile: could you tell us about the voltage imaging? Any caveats?
#Drosophila #neuroscience #LearningAndMemory #MushroomBody #KenyonCells #engran #MultisensoryIntegration