#med1 — Public Fediverse posts

α⧸ω ST phosphorylation diagrams for human & mouse mediator complex subunit 29 (#MED29:p, aka #MED2:p). Unlike #MED1:p, this sequence does not use phosphorylation, even though its only has a few, scattered helical domains. Much of the information about this gene is buried in the 'zines under the subunit's older (but salacious) name "Intersex-like, IXL" (e.g., Kuuselo, 2007 https://pubmed.ncbi.nlm.nih.gov/17332321/) #proteomics #mediator

What is now #MED1:p has gone under many names in the 'zines, making the written accounts of its adventures difficult to navigate. Also known as: Activator-recruited cofactor 205 kDa component; Peroxisome proliferator-activated receptor-binding protein; Thyroid hormone receptor-associated protein complex 220 kDa component; Thyroid receptor-interacting protein; Vitamin D receptor-interacting protein complex component; & p53 regulatory protein RB18A. #proteomics #mediator

α⧸ω ST phosphorylation diagrams for human & mouse mediator complex subunit 1 (#MED1:p). Both sequences are have an nward structured domain, followed by a complex, multiple acceptor phosphoIDR that extends to the C-terminus. In addition to phosphorylation, this region features a number of interesting low complexity domains. #proteomics #mediator

1st weekly digest of #GeneRegulation papers:

🧬#TranscriptionFactor atlas of differentiation https://www.sciencedirect.com/science/article/pii/S0092867422014702

🧬 #TFbinding directed heterochromatin (#ZFP462) https://www.nature.com/articles/s41556-022-01051-2

🧬#3Dgenome organisation of nuclear speckles & splicing https://www.biorxiv.org/content/10.1101/2023.01.04.522632v1

🧬 Nuclear partitioning by charge blocks (#MED1, #PolII) https://www.sciencedirect.com/science/article/pii/S0092867422015264

🧬 Transient loss of #Polycomb induces an #epigenetic cancer fate https://www.biorxiv.org/content/10.1101/2023.01.04.522799v1

🧬 RGT: a toolbox for NGS analysis https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1