#transcriptionfactor — Public Fediverse posts

Rewiring of Gene Regulatory Networks #GRNs facilitates novel #TranscriptionFactor interactions & innovation. @MicrobialMatts @PierceinScience @TaylorLabGroup reveal three key TF properties that speed this process: high activation, high expression, and pre-existing low-level affinity for novel target genes #PLOSBiology https://plos.io/405beXL

Rewiring of Gene Regulatory Networks #GRNs facilitates novel #TranscriptionFactor interactions & innovation. @MicrobialMatts @PierceinScience @TaylorLabGroup reveal three key TF properties that speed this process: high activation, high expression, and pre-existing low-level affinity for novel target genes #PLOSBiology https://plos.io/405beXL

Which #transcription factor binding sites matter for gene regulation?
Michelamaresca, Teun van den Brand, Elzo de Wit et al find that maintenance of open #chromatin better predicts gene regulation by pioneering #transcriptionfactor SOX2 than mere binding alone
https://www.embopress.org/doi/full/10.15252/embj.2022113150

Which #transcription factor binding sites matter for gene regulation?
Michelamaresca, Teun van den Brand, Elzo de Wit et al find that maintenance of open #chromatin better predicts gene regulation by pioneering #transcriptionfactor SOX2 than mere binding alone
https://www.embopress.org/doi/full/10.15252/embj.2022113150

Human individual variation in gene expression is used to characterize the co-regulatory processes underlying gene co-activity & indicates #transcriptionfactor expression as the main co-activity determinant ➡️ https://www.embopress.org/doi/full/10.15252/msb.202211392
@robin_andersson
#generegulation #systemsbiology

Human individual variation in gene expression is used to characterize the co-regulatory processes underlying gene co-activity & indicates #transcriptionfactor expression as the main co-activity determinant ➡️ https://www.embopress.org/doi/full/10.15252/msb.202211392
@robin_andersson
#generegulation #systemsbiology

How about some #OpenAccess #PlantScience?✅🔓⬇️
Read on to learn how Zhang et al. determined that conserved #noncoding sequences correlate with distant #gene contacts!
https://doi.org/10.1111/jipb.13465
@wileyplantsci
#Arabidopsis #Brassica #TranscriptionFactor #tf #histone

Talk about some *sweet* findings!
Xu et al. explore the molecular mechanism behind #sorbitol-induced flower bud formation via the MADS-box #TranscriptionFactor EjCAL in #loquat.
https://doi.org/10.1111/jipb.13439
@wileyplantsci
#JIPB #PlantScience #CropScience #tree #fruit #Rosaceae

1st weekly digest of #GeneRegulation papers:

🧬#TranscriptionFactor atlas of differentiation https://www.sciencedirect.com/science/article/pii/S0092867422014702

🧬 #TFbinding directed heterochromatin (#ZFP462) https://www.nature.com/articles/s41556-022-01051-2

🧬#3Dgenome organisation of nuclear speckles & splicing https://www.biorxiv.org/content/10.1101/2023.01.04.522632v1

🧬 Nuclear partitioning by charge blocks (#MED1, #PolII) https://www.sciencedirect.com/science/article/pii/S0092867422015264

🧬 Transient loss of #Polycomb induces an #epigenetic cancer fate https://www.biorxiv.org/content/10.1101/2023.01.04.522799v1

🧬 RGT: a toolbox for NGS analysis https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1

1st weekly digest of #GeneRegulation papers:

🧬#TranscriptionFactor atlas of differentiation https://www.sciencedirect.com/science/article/pii/S0092867422014702

🧬 #TFbinding directed heterochromatin (#ZFP462) https://www.nature.com/articles/s41556-022-01051-2

🧬#3Dgenome organisation of nuclear speckles & splicing https://www.biorxiv.org/content/10.1101/2023.01.04.522632v1

🧬 Nuclear partitioning by charge blocks (#MED1, #PolII) https://www.sciencedirect.com/science/article/pii/S0092867422015264

🧬 Transient loss of #Polycomb induces an #epigenetic cancer fate https://www.biorxiv.org/content/10.1101/2023.01.04.522799v1

🧬 RGT: a toolbox for NGS analysis https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1

'Here, we performed uniform gain-of-function screens of all 44 human FOX transcription factors to identify and classify new regulators of the Wnt/β-catenin pathway. By combining β-catenin reporter assays with Wnt pathway-focused qPCR arrays and proximity proteomics of selected FOX family members, we determine that most FOX proteins are involved in the regulation of Wnt pathway activity and the expression of Wnt ligands and target genes.'

#Preprint #Wnt #TranscriptionFactor #MolecularBiology

https://www.biorxiv.org/content/10.1101/2022.12.13.520306v1?med=mas

This is cool. New regulatory interaction for a very old #TranscriptionFactor! 😮

@pwatnick group

https://www.pnas.org/doi/10.1073/pnas.2210115119