#mechanosensing — Public Fediverse posts

📰 "Cellular mechanosensing on a cell-scale stiffness gradient substrate"
https://doi.org/doi:10.1039/d5sm00592b
https://pubmed.ncbi.nlm.nih.gov/41404951/
#Mechanosensing #Mechanical #Cell

📰 "The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity"
https://doi.org/doi:10.1073/pnas.2515392122
https://pubmed.ncbi.nlm.nih.gov/41400996/
#Mechanosensing #Kinesin #Cell

PhD Researcher, Intestinal Mechanobiology and Inflammation
University of Stuttgart

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/

#EpithelialcellBiologyIntestine #Inflammation #inflammatoryboweldisease #mechanobiology #mechanosensing #organoids #ScienceJobs #hi...
https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/?fsp_sid=6521

PhD Researcher, Intestinal Mechanobiology and Inflammation
University of Stuttgart

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/

#EpithelialcellBiologyIntestine #Inflammation #inflammatoryboweldisease #mechanobiology #mechanosensing #organoids #ScienceJobs #hi...
https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/?fsp_sid=6521

PhD Researcher, Intestinal Mechanobiology and Inflammation
University of Stuttgart

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/

#EpithelialcellBiologyIntestine #Inflammation #inflammatoryboweldisease #mechanobiology #mechanosensing #organoids #ScienceJobs #hi...
https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/?fsp_sid=6192

PhD Researcher, Intestinal Mechanobiology and Inflammation
University of Stuttgart

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/

#EpithelialcellBiologyIntestine #Inflammation #inflammatoryboweldisease #mechanobiology #mechanosensing #organoids #ScienceJobs #hi...
https://jobrxiv.org/job/university-of-stuttgart-27778-phd-researcher-intestinal-mechanobiology-and-inflammation/?fsp_sid=6192

📰 "Tubulin Acetylation and the Cellular Mechanosensing and Stress Response"
https://doi.org/doi:10.1007/978-3-031-91459-1_5
https://pubmed.ncbi.nlm.nih.gov/40593209/
#Mechanosensing #Microtubule #Mechanical

📰 "Macrophage response to fibrin structure mediated by Tgm2-dependent mitochondrial mechanosensing"
https://doi.org/doi:10.1016/j.bioactmat.2025.04.022
https://pubmed.ncbi.nlm.nih.gov/40331213/
#Mechanosensing #Mechanical #Cell

📰 "Liquid-Liquid Phase Separation-Mediated Cellular-Scale Compartmentalization of Hydrogel Covalent Cross-Linking Promotes Microtubule-Based Mechanosensing"
https://doi.org/doi:10.1021/jacs.5c00079
https://pubmed.ncbi.nlm.nih.gov/40252026/
#Mechanosensing #Extracellular #Microtubule #Mechanical

My next @preLights post is out. I saw this first preprint from the Storer lab a while back (thanks to a toot from @CellySally) and took some time over writing it but I think it was worth it!

I really enjoyed going back to some developmental biology with this study on how the ECM and mechanical environment influence limb regeneration. Also, nice that my PhD department, PDN, was heavily involved!

https://prelights.biologists.com/highlights/hyaluronic-acid-and-emergent-tissue-mechanics-orchestrate-digit-tip-regeneration/

#preprint #regeneration #mechanosensing #ECM

My next @preLights post is out. I saw this first preprint from the Storer lab a while back (thanks to a toot from @CellySally) and took some time over writing it but I think it was worth it!

I really enjoyed going back to some developmental biology with this study on how the ECM and mechanical environment influence limb regeneration. Also, nice that my PhD department, PDN, was heavily involved!

https://prelights.biologists.com/highlights/hyaluronic-acid-and-emergent-tissue-mechanics-orchestrate-digit-tip-regeneration/

#preprint #regeneration #mechanosensing #ECM

📰 "Nanoscale distribution of bioactive ligands on biomaterials regulates cell mechanosensing through translocation of actin into the nucleus"
https://doi.org/doi:10.1073/pnas.2501264122
https://pubmed.ncbi.nlm.nih.gov/40042901/
#Mechanosensing #Cytoskeleton #Cell

Very happy to see the review I wrote on mechanosensing by the endoplasmic reticulum (ER) published @J_Cell_Sci! I’ve really enjoyed studying the ER and hope to contribute some research articles soon.

#EndoplasmicReticulum #review #mechanosensing

https://journals.biologists.com/jcs/article/138/4/JCS263503/367029/The-emerging-roles-of-the-endoplasmic-reticulum-in

📰 "The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction"
https://doi.org/doi:10.1242/jcs.263503
https://pubmed.ncbi.nlm.nih.gov/39976266/
#Mechanosensing #Extracellular #Mechanical

📰 "Mouse scalp development requires Rac1 and SRF for the maintenance of mechanosensing mesenchyme"
https://www.biorxiv.org/content/10.1101/2025.02.11.637680v1?rss=1 #Mechanosensing #Mechanical #Actin

📰 "Tissue-dependent mechanosensing by cells derived from human tumors"
https://doi.org/doi:10.1101/2025.01.11.632563
https://pubmed.ncbi.nlm.nih.gov/39868185/
#Mechanosensing #Extracellular #Mechanical

📰 "Mitochondria mechanosensing: The powerhouse fueling cellular force signaling"
https://doi.org/doi:10.1016/j.cub.2024.12.006
https://pubmed.ncbi.nlm.nih.gov/39837277/
#Mechanosensing #Mechanical #Actomyosin

📰 "Tissue-dependent mechanosensing by cells derived from human tumors"
http://biorxiv.org/cgi/content/short/2025.01.11.632563v1?rss=1 #Mechanosensing #Extracellular #Mechanical

📰 "Biophysical and Structural Features of alphabetaT-Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T-Cell Activation"
https://doi.org/doi:10.1111/imr.13432
https://pubmed.ncbi.nlm.nih.gov/39745432/
#Mechanosensing #Mechanical #Cell

News from Till:

Delighted to announce a new #EPSRC project on #microfluidics to study #mechanosensing. With #WarwickUni colleagues Michael Smutny and Sascha Ott, Melikhan Tanyeri from Duquesne University, and 3i as project partner:

https://gow.epsrc.ukri.org/NGBOViewGrant.aspx?GrantRef=EP/X026663/1

News from Till:

Delighted to announce a new #EPSRC project on #microfluidics to study #mechanosensing. With #WarwickUni colleagues Michael Smutny and Sascha Ott, Melikhan Tanyeri from Duquesne University, and 3i as project partner:

https://gow.epsrc.ukri.org/NGBOViewGrant.aspx?GrantRef=EP/X026663/1

A fly library of fluorescently labeled RhoGEF/GAP to unveil molecular mechanisms of de novo junction formation and neighbor response upon cell division.
#Drosophila #development #biology #CellDivision #MechanoBiology #MechanoSensing
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00062-3

New #preprint from Ardem Patapoutian's lab:

'Here, we show that humans lacking PIEZO2 exhibit impaired bowel sensation and motility. Piezo2 in mouse dorsal root but not nodose ganglia is required to sense gut content, and this activity slows down food transit rates in the stomach, small intestine, and colon. Indeed, Piezo2 is directly required to detect colon distension in vivo. Our study unveils the mechanosensory mechanisms that regulate the transit of luminal contents throughout the gut, which is a critical process to ensure proper digestion, nutrient absorption, and waste removal.'

#Mechanosensing #MucosalImmunology
#Piezo

https://www.biorxiv.org/content/10.1101/2022.11.27.518109v1?med=mas

@jocelyn_etienne @Rxiv_cytoskeleton @mechanobiology maybe #cellmigration and #mechanosensing #mechanobiology?