#drugrepurposing — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #drugrepurposing, aggregated by home.social.
-
It's interesting that they paired a talk on ergothioneine, which is primarily thought of as an anti-oxidant (though as discussed in the video, there may be more to its MOA) with hemin, which is a potent pro-oxidant.
There was an in vitro study that suggested hemin might be useful in acute Covid, but it never went anywhere AFAIK. The paper is still interesting for background on hemin as an HO-1 inducer -
https://pmc.ncbi.nlm.nih.gov/articles/PMC8563742/ -
It's interesting that they paired a talk on ergothioneine, which is primarily thought of as an anti-oxidant (though as discussed in the video, there may be more to its MOA) with hemin, which is a potent pro-oxidant.
There was an in vitro study that suggested hemin might be useful in acute Covid, but it never went anywhere AFAIK. The paper is still interesting for background on hemin as an HO-1 inducer -
https://pmc.ncbi.nlm.nih.gov/articles/PMC8563742/ -
It's interesting that they paired a talk on ergothioneine, which is primarily thought of as an anti-oxidant (though as discussed in the video, there may be more to its MOA) with hemin, which is a potent pro-oxidant.
There was an in vitro study that suggested hemin might be useful in acute Covid, but it never went anywhere AFAIK. The paper is still interesting for background on hemin as an HO-1 inducer -
https://pmc.ncbi.nlm.nih.gov/articles/PMC8563742/ -
It's interesting that they paired a talk on ergothioneine, which is primarily thought of as an anti-oxidant (though as discussed in the video, there may be more to its MOA) with hemin, which is a potent pro-oxidant.
There was an in vitro study that suggested hemin might be useful in acute Covid, but it never went anywhere AFAIK. The paper is still interesting for background on hemin as an HO-1 inducer -
https://pmc.ncbi.nlm.nih.gov/articles/PMC8563742/ -
https://www.europesays.com/ie/472236/ Largest blood protein genetics study reveals new precision medicine opportunities #blood #Cell #DrugRepurposing #Éire #Genetic #Genetics #Healthcare #IE #Ireland #medicine #Research #Science
-
Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance [2020]
abstract:
https://pubmed.ncbi.nlm.nih.gov/32777256/preprint can be downloaded here:
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3463265#orosomucoid #fatigue #erythromycin #DrugRepurposing #DrugDevelopment
-
Blood pressure drug, meet brain cancer. Scientists just uncovered how hydralazine “silences” glioblastoma cells, a 70-year-old medical mystery solved, and a ray of hope for patients. Is drug repurposing the future? Explore more at The Urban Herald!
https://theurb.co/hydralazine-brain-tumor-drug#BrainCancer #Glioblastoma #CancerBreakthrough #MedicalInnovation #DrugRepurposing #CancerResearch #HealthNews #NeuroOncology #Hydralazine #ScienceExplained #News
-
Brayden Yellman, MD | Underappreciated Co-Morbidities in ME/CFS
video uploaded Oct. 16, 2025
https://youtu.be/od0epKW19og[13:03] hydroxyurea used to treat a person with POTS and MCAS
Here's an article on the topic:
Efficacy and toxicity of hydroxyurea in mast cell activation syndrome patients refractory to standard medical therapy: retrospective case series [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9388361/"First used 60 years ago for chronic myeloproliferative neoplasms, HU is now standard of care in reducing the severity of sickle cell disease (SCD) (McGann and Ware 2015). In this context, it is of interest that in animal models and human subjects with SCD, medications that reduce MC activation decreased bone pain (Vincent et al. 2013, 2016). HU also inhibits replication of human immunodeficiency virus-1 (HIV-1) and has been used in therapy of cyanotic congenital heart disease (Lori and Lisziewicz 2000; Reiss et al. 2007). A theoretic explanation for effectiveness of HU in these diseases include reducing MC activity independent of anti-proliferative effects. HU could decrease activity and ability of GI mucosal MCs that capture HIV-1 and mediate trans-infection of CD4 + T cells (Jiang et al. 2015). Similarly, HU could reduce the activity of the increased numbers of chymase-containing MCs in lung tissue of congenital heart disease patients and, thereby, decrease severity of these pulmonary and cardiac diseases (Hamada et al. 1999)."
The mechanisms are probably quite complex. One facet is that hydroxyurea increases fetal hemoglobin production and RBC membrane flexibility - which could increase O2 perfusion. Hypoxia activates mast cells.
#MECFS #MCAS #POTS #DrugRepurposing #hydroxyurea #MastCells #immunology
-
A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00229lots of details on #pathophysiology in this review
#MECFS #LongCovid #metformin #DrugRepurposing #medicine #health
#WASF3 -
My latest: Medicines Reimagined – #Repurposing Drugs For New Indications via @forbes https://www.forbes.com/sites/judystone/2025/08/27/medicines-reimagined--repurposing-drugs-for-new-indications/ #FDA #DrugRepurposing #MotorNeuronDisease #Malaria #RespiratoryPapilloma #HPV #Remedi4All #iDR25
-
📄 'Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer' - a DrugRxiv #Preprint on #ScienceOpen:
➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGARXIV.PR000030.v1
#REPO4EU #DrugRepurposing #AnaplasticThyroidCancer #ExtracellularVesicles #Vandetanib #LiquidBiopsy
-
📄 'Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer' - a DrugRxiv #Preprint on #ScienceOpen:
➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGARXIV.PR000030.v1
#REPO4EU #DrugRepurposing #AnaplasticThyroidCancer #ExtracellularVesicles #Vandetanib #LiquidBiopsy
-
📄 'Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer' - a DrugRxiv #Preprint on #ScienceOpen:
➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGARXIV.PR000030.v1
#REPO4EU #DrugRepurposing #AnaplasticThyroidCancer #ExtracellularVesicles #Vandetanib #LiquidBiopsy
-
"A foundation model for clinician-centered drug repurposing"
There is a strong need for #drugrepurposing given how much clinical trials cost and how many drugs are already developed.
TxGNN predicts indications & contraindications:
https://www.nature.com/articles/s41591-024-03233-x
#medTwitter #medicine #AI -
Just finished the final review with the EU Commission's #HADEA Project Officer and experts for our concluded #H2020 #drugrepurposing project, REPO-TRIAL (https://repo-trial.eu/). We have already made a smooth transition to the much larger #HorizonEurope follow-up project, #REPO4EU (https://repo4.eu/) which is building a a drug repurposing platform. Stay tuned!
-
Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion. https://doi.org/10.1186/s10020-023-00664-z #PolycysticKidneyDisease #Pkd #Adpkd #DrugRepurposing #SignatureReversion