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  1. Anyone have recommendations on good papers on critical illness neuropathy and myopathy? #emimcc #critcaresky #cccsky

  2. Systemic vascular resistance is not a realiable measure of left ventriclar afterload. In this study, noradrenaline actually decreased left ventricular wall stress even though SVR increased. Higher heart rate and contractility leads to a smaller LV, lower wall stress. #emimcc #cccsky #cardiosky

    Systemic vascular resistance: ...

  3. T-EDTA to prevent CVC thrombosis. Only difference is lower use of alteplase. Thoughts? #emimcc #ansky #cccsky jamanetwork.com/journals/jam...

  4. RCTs have shown no benefit from IABP in acute ischemic cardiogenic shock, an observatiobal trial isn’t even hypothesis generating. No grounds for new IABP trials in this population in my opinion. #cardiosky #cccsky #emimcc

    Intra-aortic balloon pump vers...

  5. Bayesian reanalysis can be a great way to assess a contested trial, by showing how strong a prior you need to nullify or inverse the results. I don't understand why they did not include a pessimistic prior here though (even as I see a sceptical one more realistic). #emimcc #cardiosky #cccsky #stats

    RE: https://bsky.app/profile/did:plc:77cp7kgakti2uthqnkkdaqum/post/3mkpw474mis2q

  6. In a patient with high-risk pulmonary embolism, but no sign of hypoperfusion, would you start LMWH or UFH? #emimcc #cardisky #cccsky #critcaresky

  7. This should be the death of Impella outside of severe cardiogenic shock. High probability it increases mortality. #cardiosky #cccsky

    RE: https://bsky.app/profile/did:plc:yrhfut7mmcbabz6mgjqcyums/post/3mi7xwmgjrs2k

  8. Can we please stop referring to lactate as a perfusion marker? It’s no more so and no better than blood pressure. #emimcc #cccsky

  9. One point that isn't mentioned here but too often forgotten when noradrenaline seemingly isn't working: Are you actually using a representative blood pressure? Not so rare that a better (more central or better line) fixes the problem. Look at the whole patient, not just a number! #emimcc #cccsky

    RE: https://bsky.app/profile/did:plc:vmwckmxogx3lipqxlmn76mbe/post/3mh67jqfw3z2h

  10. To write a "state-of-the-art review" of diastolic dysfunction in acute and critical illness with an emphasis on SGLT2-inhibition and not mention the DEFENDER trial is quite something. #cardisky #emimcc #cccsky www.jacc.org/doi/10.1016/...

    Diastolic Dysfunction in Acute...

  11. Does anyone have a good paper on pearls and pitfalls of CVP measurements? #emimcc #cccsky

  12. Levosimendan is quite often seen as a "safe" inodilator with respect to ventricular arrhythmias. I don't think it is, and this trial in my view supports that. Also, drugs with very long half lives are generally not a good idea in the critically ill #cardiosky #emimcc #cccsky

    Levosimendan to Facilitate Wea...

  13. New results from DanGer Shock ,shows it's those with the lower systolic pressure (the sicker patients) that benefit from Impella. #emimcc #cardiosky #cccsky jamanetwork.com/journals/jam...

  14. I’m reading up on the risk of increased intrapulmonary shunting and hypoxia posed by nitroprusside, and thinking, should this not also apply to other vasodilators like nitroglycerine and milrinone? Can only see it described for nitroprusside #emimcc #cccsky

  15. One of my strong pet peeves: never start vasopressin based on a fixed cutoff for noradrenaline and never without an echo. I strongly oppose the algorithm proposed here #emimcc #cccsky

    RE: https://bsky.app/profile/did:plc:oaaejshh5ta7u2zzmczevuyi/post/3m5hfnacyps2y

  16. Likewise, low blood pressure is a reliable sign of shock and malperfusion in sepsis/distributive shock, but not in other, especially cardiogenic shock. #emimcc #cccsky

    RE: https://bsky.app/profile/did:plc:kgfqlfzek5twmq7ahzc5ws46/post/3m2pk6yahlk23

  17. Finally some good evidence for whether DOACs can be effective in treatment of left ventricular thrombus. Is this generalisable to all DOACs? #cardiosky #cccsky www.jacc.org/doi/10.1016/...

    Rivaroxaban vs Warfarin in Acu...

  18. Granted, few patients where still available after 4 years, but still odd to have 0 mortality from 4 to 10 years in a population that has had cardiogneic shock #cccsky #cardiosky #emimcc

    RE: https://bsky.app/profile/did:plc:pqur3apsmhyw756zvruofulp/post/3lxp2qv4ttc2c

  19. Extremely striking difference in utilisation of Impella in the US vs UK and Canada. #cardiosky #cccsky #emimcc jamanetwork.com/journals/jam...

  20. Great thread! The one thing I will disagree on is the value of EF. It is misused and misunderstood but far from useless. It is a measure of ventriculoarterial coupling and used in conjunction with stroke volume truly informstive of the balamce between LV function and afterload. #emimcc #cccsky

    RE: https://bsky.app/profile/did:plc:pdj5upxe4ocjvjltlkdai7b4/post/3lwjyglqvrc2l