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#upf1 — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #upf1, aggregated by home.social.

  1. Cosmin Saveanu @[email protected] ·

    In a recent pre-print for a project led by Gwenael Badis and with the first author Toni Gouhier, we show that #Upf1, the core helicase of nonsense-mediated mRNA decay (#NMD), can selectively bind short poly(A) RNA and help their degradation. This is a new function for NMD!

    Images show the levels of short poly(A) tailed RNA in the Upf1-associated RNA fraction and the impact of the absence of Upf1 on the levels of this particular population (for a reporter).

    biorxiv.org/content/10.1101/20

    #upf1 #nmd
  2. Cosmin Saveanu @[email protected] ·

    Nonsense mediated mRNA decay (#NMD) is frequently a target of viral proteins since an active NMD can limit viral replication. As shown by the lovely work of Fiorini and colleagues, the N protein of #SARS-CoV-2 physically and functionally interact with #Upf1 and #Upf2, two core NMD factors. These results complement previously published studies, such as the one from the Makino group, 2018, on the murine hepatitis virus, a related coronavirus.

    pubmed.ncbi.nlm.nih.gov/398313
    pubmed.ncbi.nlm.nih.gov/302974

    #rna

    #nmd #sars #upf1 #upf2 #rna
  3. Cosmin Saveanu @[email protected] ·

    Very happy to see the story led by Marc Graille and to which we collaborated published as a pre-print. It shows that specific protein-protein interaction motifs involved in nonsense-mediated #mRNA decay (#NMD) have been preserved over billions of years of evolution.

    Yeast Nmd4 is probably the most reduced form equivalent of mammalian SMG-6 and enhances the binding of #Upf1 to RNA.

    biorxiv.org/content/10.1101/20

    #upf1 #nmd #mrna