#uncoupling — Public Fediverse posts

Had to go find a video to show older brother what a giggle loop is. #Uncoupling

UCP5 is also found in the central nervous system of both species, with a surprise appearance in sperm/testis in humans. The role of the protein has been as a hypothetical regulator of reactive oxygen species (Ramsden 2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432969) & more recently as an anion transporter (Gorgolione 2019 https://www.sciencedirect.com/science/article/pii/S0005272819300945)

Human & mouse uncoupling protein 5 (#UCP5:p | #SLC25A14:p)―GPMDB tissue tabbulations #proteomics #uncoupling

The next one in the series is located in the central nervous system of both species, probably in modulating glutamate controlled proton gradients in neuron mitochondrial inner membranes. It does not appear to have any role in thermogenisis.

Human & mouse uncoupling protein 4 (#UCP4:p | #SLC25A27:p)―GPMDB tissue tabbulations #proteomics #uncoupling

UCP3:p is also a mitochondrial inner membrane transport molecule, but it is most frequently observed in striated muscle. The idea that this sequence is used to "uncouple" ATP production to produce heat has been challenged & alternate functions proposed, e.g. Di Marchi, 2011 (https://pubmed.ncbi.nlm.nih.gov/21775425/)

Human & mouse uncoupling protein 3 (#UCP3:p | #SLC25A9:p)―GPMDB tissue tabbulations #proteomics #uncoupling

Like UCP1:p, this protein seems to be utilized more frequently by mice compared to humans, although its tissue distribution is different. The case for its role in non-shivering thermogenisis is less established than that of UCP1:p.

Human & mouse uncoupling protein 2 (#UCP2:p | #SLC25A8:p)―GPMDB tissue tabbulations #proteomics #uncoupling

This protein is most frequently discussed for its role in obligate hibernator mammal brown fat. It is localized in the mitochondrial inner membrane and it functions when the animal is being roused from hibernation, shutting down ATP production in mitochondria, channeling the energy produced by the organelle into heat instead. In non-hibernating mammals its role is a little mysterious.

Human & mouse uncoupling protein 1 (#UCP1:p | #SLC25A7:p)―GPMDB tissue tabbulations #proteomics #uncoupling

So I never saw this creative and contentious financial #uncoupling coming. 👀

And now a restraining order? Say it isn’t so, stars of my #Seventies high school slow-dance #musical lineups… say it isn’t so.

Daryl Hall Gets #Restraining Order Against John Oates in #HallandOates confidential #LegalBattle.

https://variety.com/2023/music/news/hall-and-oates-lawsuit-restraining-order-1235805425/