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#oncoprotein — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #oncoprotein, aggregated by home.social.

  1. CRAIG M CREWS @[email protected] ·

    Ever try to #drug an #oncoprotein only to have the #tumor lose its dependency on it and become drug resistant? Introducing #RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with #Halda Therapeutics. RIPTACs selectively kill cells by differentially accumulating an antiproliferative agent via an induced Protein:Protein Interaction (#PPI) to a differentially expressed protein. Importantly, target protein function is not needed for RIPTAC action.
    biorxiv.org/cgi/content/short/

    #drug #oncoprotein #tumor #riptacs #halda #ppi
  2. CRAIG M CREWS @[email protected] ·

    Ever try to #drug an #oncoprotein only to have the #tumor lose its dependency on it and become drug resistant? Introducing #RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with #Halda Therapeutics. RIPTACs selectively kill cells by differentially accumulating an antiproliferative agent via an induced Protein:Protein Interaction (#PPI) to a differentially expressed protein. Importantly, target protein function is not needed for RIPTAC action.
    biorxiv.org/cgi/content/short/

    #drug #oncoprotein #tumor #riptacs #halda #ppi
  3. CRAIG M CREWS @[email protected] ·

    Ever try to #drug an #oncoprotein only to have the #tumor lose its dependency on it and become drug resistant? Introducing #RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with #Halda Therapeutics. RIPTACs selectively kill cells by differentially accumulating an antiproliferative agent via an induced Protein:Protein Interaction (#PPI) to a differentially expressed protein. Importantly, target protein function is not needed for RIPTAC action.
    biorxiv.org/cgi/content/short/

    #drug #oncoprotein #tumor #riptacs #halda #ppi
  4. CRAIG M CREWS @[email protected] ·

    Ever try to #drug an #oncoprotein only to have the #tumor lose its dependency on it and become drug resistant? Introducing #RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with #Halda Therapeutics. RIPTACs selectively kill cells by differentially accumulating an antiproliferative agent via an induced Protein:Protein Interaction (#PPI) to a differentially expressed protein. Importantly, target protein function is not needed for RIPTAC action.
    biorxiv.org/cgi/content/short/

    #ppi #halda #riptacs #tumor #oncoprotein #drug
  5. CRAIG M CREWS @[email protected] ·

    Ever try to #drug an #oncoprotein only to have the #tumor lose its dependency on it and become drug resistant? Introducing #RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with #Halda Therapeutics. RIPTACs selectively kill cells by differentially accumulating an antiproliferative agent via an induced Protein:Protein Interaction (#PPI) to a differentially expressed protein. Importantly, target protein function is not needed for RIPTAC action.
    biorxiv.org/cgi/content/short/

    #drug #oncoprotein #tumor #riptacs #halda #ppi