#oncogenic — Public Fediverse posts

Last year, researchers at the University of California, Riverside, developed a novel “molecular crowbar” strategy to degrade the #oncogenic enzyme Pin1, a #protein that is overexpressed in many #tumors including #pancreatic cancer. They designed compounds that bind to Pin1 and destabilize its structure, causing its cellular degradation.
#Oncology #Cancer #sflorg
https://www.sflorg.com/2025/11/ongy11122501.html

How do tumor-derived signals affect distant tissues?
In flies, Morihiro Okada, Sa Kan Yoo et al find that #oncogenic stress can program systemic metabolism via #NetrinB - a guidance cue previously thought to only act within certain tissues
https://www.embopress.org/doi/10.15252/embj.2022111383