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#macrocycle — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #macrocycle, aggregated by home.social.

  1. How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9 that were initially discovered by mRNA display and investigated by Merck in a clinical phase 3 study as enlicitide.

    pubs.acs.org/doi/10.1021/acs.j
    pubs.acs.org/doi/10.1021/acs.j

    #DrugDiscovery #Peptide #Macrocycle #Cholesterol #PCSK9