#lymphomas — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #lymphomas, aggregated by home.social.
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There's a handful of reasons that mature b-cell #lymphomas are treatment sensitive and often cured even when at an advanced stage.
One being, immune cells, lymphocytes, are inherently prone to dye off after its job is done, - and very sensitive to chemo and radiation.
Another: you can target and kill the mature forms of b-cells and more will be regenerated from stem cells. The immature cells don't yet have the cd20, or cd19, or cd22 molecule on the cell surface.
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Mycosis Fungoides (MF) and Sezary syndrome(SS) are extra-nodal cutaneous T cell #lymphomas
Long term outcomes of non-myeloablative allogeneic stem cell rescue for MF and SS - full text:
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Cancers are typically clonal -- a tumor of many cells arising from a single cell of origin.
In immune-cell cancers this is easily ascertained because each cell will have a molecule with affinity to one antigen.
Just my thought: that Bi-clonal #lymphomas are rare supports the notion that bad luck - random copy errors - is the most common cause for #cancer; else poly-clonal cancers would be common. @dcnorris
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🔬💉 #Lymphomas: Cologne researchers have developed an innovative strategy to make CAR-T cell therapy for lymph node cancer safer and more effective.
💡 The idea: an "AND" switch ensures that tumour cells are attacked in a more targeted manner because they are only attacked if two specific proteins are present on the cell surface.
Read more ➡️ https://uni.koeln/NMEK4
The paper was published in Cell Reports Medicine 👇
https://www.sciencedirect.com/science/article/pii/S2666379124000442 -
Researchers discovered how T-cell #lymphomas grow so quickly and how this process can be stopped by inhibiting the tumor's sugar uptake, causing its cells to die off: http://go.tum.de/776233
#cancercells #genes #sugarmetabolism
📷A. Eckert
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CD4+ CAR T-cell expansion is associated with response and therapy-related toxicities in patients with B-cell #lymphomas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471494/
#MEDMASTODON #lymphoma #Cancer
#ClinicalResearch #Oncology #Medicine #lymsm @[email protected]