#anapc — Public Fediverse posts

A GPMDB ubiquitination PTM diagram for human tumour protein p63 (#TP63:p). The 'zines are pretty adamant that the protein is a Ub substrate of the anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003458/). It has not been observed to be afflicted with SUMOylation. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human tumour protein p63 (#TP63:p). The 'zines are pretty adamant that the protein is a Ub substrate of the anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003458/). It has not been observed to be afflicted with SUMOylation. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human tumour protein p63 (#TP63:p). The 'zines are pretty adamant that the protein is a Ub substrate of the anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003458/). It has not been observed to be afflicted with SUMOylation. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human tumour protein p63 (#TP63:p). The 'zines are pretty adamant that the protein is a Ub substrate of the anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003458/). It has not been observed to be afflicted with SUMOylation. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell divlsion cycle 20 (#CDC20:p). Both sequences have a dragon's neck type N-terminal phosphoIDR with three high occupancy S/TP acceptors. Phosphorylation is known to prevent association with the anaphase promoting complex. The cward shiny region is a kinase-resistant, WD40 repeat beta-propeller. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell divlsion cycle 20 (#CDC20:p). Both sequences have a dragon's neck type N-terminal phosphoIDR with three high occupancy S/TP acceptors. Phosphorylation is known to prevent association with the anaphase promoting complex. The cward shiny region is a kinase-resistant, WD40 repeat beta-propeller. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell divlsion cycle 20 (#CDC20:p). Both sequences have a dragon's neck type N-terminal phosphoIDR with three high occupancy S/TP acceptors. Phosphorylation is known to prevent association with the anaphase promoting complex. The cward shiny region is a kinase-resistant, WD40 repeat beta-propeller. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell divlsion cycle 20 (#CDC20:p). Both sequences have a dragon's neck type N-terminal phosphoIDR with three high occupancy S/TP acceptors. Phosphorylation is known to prevent association with the anaphase promoting complex. The cward shiny region is a kinase-resistant, WD40 repeat beta-propeller. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human Targeting Protein for Xenopus plus end-directed kinesin-like protein 2 (#TPX2:p). There are ubiquitination acceptors on this sequence that the 'zines suggest are substrates for anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291225/), it would appear that SUMOylation is doing some heavy lifting with this one, too. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human Targeting Protein for Xenopus plus end-directed kinesin-like protein 2 (#TPX2:p). There are ubiquitination acceptors on this sequence that the 'zines suggest are substrates for anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291225/), it would appear that SUMOylation is doing some heavy lifting with this one, too. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human Targeting Protein for Xenopus plus end-directed kinesin-like protein 2 (#TPX2:p). There are ubiquitination acceptors on this sequence that the 'zines suggest are substrates for anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291225/), it would appear that SUMOylation is doing some heavy lifting with this one, too. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human Targeting Protein for Xenopus plus end-directed kinesin-like protein 2 (#TPX2:p). There are ubiquitination acceptors on this sequence that the 'zines suggest are substrates for anaphase promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291225/), it would appear that SUMOylation is doing some heavy lifting with this one, too. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 10 (#ANAPC10:p). This subunit does not have any high occupancy phosphorylation acceptors, although both sequence have a low occupancy acceptor T7+phosphoryl. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 10 (#ANAPC10:p). This subunit does not have any high occupancy phosphorylation acceptors, although both sequence have a low occupancy acceptor T7+phosphoryl. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 10 (#ANAPC10:p). This subunit does not have any high occupancy phosphorylation acceptors, although both sequence have a low occupancy acceptor T7+phosphoryl. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 10 (#ANAPC10:p). This subunit does not have any high occupancy phosphorylation acceptors, although both sequence have a low occupancy acceptor T7+phosphoryl. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human polo like kinase 1 (#PLK1:p). This kinase is produced during G1. It is part of the mitosis coordination system that has be ubiquitylated by the anaphase promoting complex and removed for the process to proceed to completion. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human polo like kinase 1 (#PLK1:p). This kinase is produced during G1. It is part of the mitosis coordination system that has be ubiquitylated by the anaphase promoting complex and removed for the process to proceed to completion. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human polo like kinase 1 (#PLK1:p). This kinase is produced during G1. It is part of the mitosis coordination system that has be ubiquitylated by the anaphase promoting complex and removed for the process to proceed to completion. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human polo like kinase 1 (#PLK1:p). This kinase is produced during G1. It is part of the mitosis coordination system that has be ubiquitylated by the anaphase promoting complex and removed for the process to proceed to completion. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

α⧸ω ST phosphorylation diagrams for yeast anaphase promoting complex subunit 9 (#APC9:p). This subunit is present in yeast but there is no homolog in the mammalian complex. It has a single high occupancy receptor, T36+phosphoryl. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for yeast anaphase promoting complex subunit 9 (#APC9:p). This subunit is present in yeast but there is no homolog in the mammalian complex. It has a single high occupancy receptor, T36+phosphoryl. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for yeast anaphase promoting complex subunit 9 (#APC9:p). This subunit is present in yeast but there is no homolog in the mammalian complex. It has a single high occupancy receptor, T36+phosphoryl. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for yeast anaphase promoting complex subunit 9 (#APC9:p). This subunit is present in yeast but there is no homolog in the mammalian complex. It has a single high occupancy receptor, T36+phosphoryl. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase B (#AURKB:p). Involved in microtubule coordination during mitosis, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase B (#AURKB:p). Involved in microtubule coordination during mitosis, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase B (#AURKB:p). Involved in microtubule coordination during mitosis, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase B (#AURKB:p). Involved in microtubule coordination during mitosis, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 23 (#CDC23:p, aka #ANAPC8:p). Both sequences have multiple high occupancy S/TP-type acceptors on a short dragon's tail phosphoIDR. The nward bulk of the protein is composed of phosphorylation-resistant tetratricopeptide repeats. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 23 (#CDC23:p, aka #ANAPC8:p). Both sequences have multiple high occupancy S/TP-type acceptors on a short dragon's tail phosphoIDR. The nward bulk of the protein is composed of phosphorylation-resistant tetratricopeptide repeats. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 23 (#CDC23:p, aka #ANAPC8:p). Both sequences have multiple high occupancy S/TP-type acceptors on a short dragon's tail phosphoIDR. The nward bulk of the protein is composed of phosphorylation-resistant tetratricopeptide repeats. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 23 (#CDC23:p, aka #ANAPC8:p). Both sequences have multiple high occupancy S/TP-type acceptors on a short dragon's tail phosphoIDR. The nward bulk of the protein is composed of phosphorylation-resistant tetratricopeptide repeats. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase A (#AURKA:p). Involved in centrosome maturation & mitosis in general, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927175). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase A (#AURKA:p). Involved in centrosome maturation & mitosis in general, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927175). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase A (#AURKA:p). Involved in centrosome maturation & mitosis in general, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927175). #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human aurora kinase A (#AURKA:p). Involved in centrosome maturation & mitosis in general, it has been identified as a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927175). #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 7 (#ANAPC7:p). The human sequence has 2 low occupancy phosphoIDRs adjacent to the tetratricopeptide repeat helix bundles that dominate the shiny parts. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 7 (#ANAPC7:p). The human sequence has 2 low occupancy phosphoIDRs adjacent to the tetratricopeptide repeat helix bundles that dominate the shiny parts. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 7 (#ANAPC7:p). The human sequence has 2 low occupancy phosphoIDRs adjacent to the tetratricopeptide repeat helix bundles that dominate the shiny parts. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse anaphase promoting complex subunit 7 (#ANAPC7:p). The human sequence has 2 low occupancy phosphoIDRs adjacent to the tetratricopeptide repeat helix bundles that dominate the shiny parts. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human cyclin A2 (#CCNA2:p). Originally synthesized at the start of S phase, it is a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944252). This is a less busy pattern of Ub acceptors than many proteins, but it seems to get the job done. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human cyclin A2 (#CCNA2:p). Originally synthesized at the start of S phase, it is a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944252). This is a less busy pattern of Ub acceptors than many proteins, but it seems to get the job done. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human cyclin A2 (#CCNA2:p). Originally synthesized at the start of S phase, it is a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944252). This is a less busy pattern of Ub acceptors than many proteins, but it seems to get the job done. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human cyclin A2 (#CCNA2:p). Originally synthesized at the start of S phase, it is a Ub target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944252). This is a less busy pattern of Ub acceptors than many proteins, but it seems to get the job done. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 16 (#CDC16, aka #ANAPC6:p). The sequences have a C-terminal dragon's tail phosphoIDRs with 2 S/TP type acceptors. The structured nward domain is a cluster of tetratricopeptide repeat helix bundles. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 16 (#CDC16, aka #ANAPC6:p). The sequences have a C-terminal dragon's tail phosphoIDRs with 2 S/TP type acceptors. The structured nward domain is a cluster of tetratricopeptide repeat helix bundles. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 16 (#CDC16, aka #ANAPC6:p). The sequences have a C-terminal dragon's tail phosphoIDRs with 2 S/TP type acceptors. The structured nward domain is a cluster of tetratricopeptide repeat helix bundles. #proteomics #anapc

α⧸ω ST phosphorylation diagrams for human & mouse cell division cycle 16 (#CDC16, aka #ANAPC6:p). The sequences have a C-terminal dragon's tail phosphoIDRs with 2 S/TP type acceptors. The structured nward domain is a cluster of tetratricopeptide repeat helix bundles. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human never-in-mitosis gene A―NIMA―related kinase 2 (#NEK2:p). The 'zines suggest that it is a ubiquitination target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927175/). While there are some low occupancy K+SUMO2/3 modifications, the heavy lifting seems to be left up to K+Ub. #proteomics #anapc

A GPMDB ubiquitination PTM diagram for human never-in-mitosis gene A―NIMA―related kinase 2 (#NEK2:p). The 'zines suggest that it is a ubiquitination target of the anaphase-promoting complex (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927175/). While there are some low occupancy K+SUMO2/3 modifications, the heavy lifting seems to be left up to K+Ub. #proteomics #anapc