#trypanosome — Public Fediverse posts

The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. This study uses U-ExM to provide novel insights into FPC biogenesis, and reveals two previously unknown cytoskeletal structures @PLOSBiology plos.io/4n3bWi6

How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport #plosbiology https://plos.io/3Q36QV2

Chronic #trypanosome brain infection induces meningeal responses resulting in ectopic lymphoid aggregates containing #autoreactiveBcells; #autoantigens include MBP, consistent with experimentally observed #demyelination @Jquintanalcala &co #PLOSBiology https://plos.io/3R8xgpH

Chronic #trypanosome brain infection induces meningeal responses resulting in ectopic lymphoid aggregates containing #autoreactiveBcells; #autoantigens include MBP, consistent with experimentally observed #demyelination @Jquintanalcala &co #PLOSBiology https://plos.io/3R8xgpH

Chronic #trypanosome brain infection induces meningeal responses resulting in ectopic lymphoid aggregates containing #autoreactiveBcells; #autoantigens include MBP, consistent with experimentally observed #demyelination @Jquintanalcala &co #PLOSBiology https://plos.io/3R8xgpH

Chronic #trypanosome brain infection induces meningeal responses resulting in ectopic lymphoid aggregates containing #autoreactiveBcells; #autoantigens include MBP, consistent with experimentally observed #demyelination @Jquintanalcala &co #PLOSBiology https://plos.io/3R8xgpH

Chronic #trypanosome brain infection induces meningeal responses resulting in ectopic lymphoid aggregates containing #autoreactiveBcells; #autoantigens include MBP, consistent with experimentally observed #demyelination @Jquintanalcala &co #PLOSBiology https://plos.io/3R8xgpH

New leads in the quest for better anti-trypanosome drugs
"We performed phenotypic screening against trypanosomes and identified a class of cyanotriazoles (CTs) with potent trypanocidal activity both in vitro and in mouse models of Chagas disease and HAT."
#InfectiousDisease #Chagas #drugdiscovery #trypanosome

https://www.science.org/doi/10.1126/science.adh0614