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  1. Something new and interesting to think about:

    "The end of the genetic paradigm of cancer", Huang et al. 2025
    journals.plos.org/plosbiology/

    "The (apparent) paradox goes both ways: many cancers harbor no consistent driver mutations, while canonical oncogenic mutations are found in tissues that remain free of cancer [16] (see Table 1 for references). Paradoxes, according to Nils Bohr, are of course central for progress [17]—if properly recognized."

    HT @DrAnneCarpenter

    #cancer #SomaticMutationTheory #TumorMicroEnvironment