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#mir33pfpaper — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #mir33pfpaper, aggregated by home.social.

  1. KaminskiMed :verified: @[email protected] ·

    8/n last - Study funding was by @[email protected] #DiscoveryAward to @[email protected] & by @[email protected] to me & others, also supported by institutional cores, colleagues, patient advocates, sample & tissue donors
    Thank you all!!!
    #CureIPF #miR33PFPaper
    insight.jci.org/articles/view/

    #discoveryaward #cureipf #mir33pfpaper
  2. KaminskiMed :verified: @[email protected] ·

    7/n So grateful to the team, led by Dr. Ahangari, #KaminskiLab members, so many selfless collaborators including Drs Fernández-Hernando, Price, Dela Cruz, Prasse, Ivan Rosas, & Bahal (bahal.lab.uconn.edu/ that designed PNA-33) #CureIPF #miR33PFPaper
    insight.jci.org/articles/view/

    #kaminskilab #cureipf #mir33pfpaper
  3. KaminskiMed :verified: @[email protected] ·

    6/n Pharmacologic inhibition of miR-33 using PNA-33 in precision-cut lung slices obtained from bleomycin-injured mice or humans with IPF, also indicated antifibrotic effects, including reversal of profibrotic macrophage signature
    #CureIPF #miR33PFPaper
    insight.jci.org/articles/view/

    #cureipf #mir33pfpaper
  4. KaminskiMed :verified: @[email protected] ·

    5/n Impressively, loss of Mir-33 in myeloid cells, has an effect on alveolar type II cells, their mitochondrial homeostasis improved and apoptosis ⬇️
    #CureIPF #miR33PFPaper
    insight.jci.org/articles/view/

    #cureipf #mir33pfpaper
  5. KaminskiMed :verified: @[email protected] ·

    4/n Loss of miR-33 in macrophages improves mitochondrial homeostasis (function and structure) at baseline and after bleomycin injury, ⬆️ autophagy and mitophagy #CureIPF #miR33PFPaper
    insight.jci.org/articles/view/

    #cureipf #mir33pfpaper
  6. KaminskiMed :verified: @[email protected] ·

    3/n Knocking down miR-33 genetically in myeloid cells, or pharmacologically using a Peptide Nucleic Acid inhibitor designed by Dr. Bahal (PNA-33) protects mice against bleomycin-induced Pulmonary Fibrosis
    #CureIPF #miR33PFPaper
    insight.jci.org/articles/view/

    #cureipf #mir33pfpaper
  7. KaminskiMed :verified: @[email protected] ·

    2/n We first show that miR-33 is increased in BAL and lung cells obtained from IPF patients and that miR-33 target genes are decreased in IPF
    #CureIPF #miR33PFPaper
    insight.jci.org/articles/view/

    #cureipf #mir33pfpaper
  8. KaminskiMed :verified: @[email protected] ·

    1/n Our first #CurePF paper for 2023 is OUT! A novel role in Pulmonary Fibrosis for miR-33, a key regulator of macrophage immuno-metabolic response & mitochondrial function, providing evidence that inhibition may be antifibrotic
    #miR33PFPaper
    doi.org/10.1172/jci.insight.15

    #curepf #mir33pfpaper