#heme — Public Fediverse posts

The potential link btwn red #meat consumption & #cancer may be partially mediated by the high intake of #heme iron. Vegetarian & #vegan diets often surpass the #iron intake of omnivorous #diets. Well-planned #plantbased diets can be nutritionally adequate: doi.org/10.1007/s136... #nutrition #health

Plant-Based Diet and Risk of I...

How #Staphylococcus aureus 'steals' #iron from our #blood during infections.

#kleptophagy #kleptoparasitism #heme

https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html

How #Staphylococcus aureus 'steals' #iron from our #blood during infections.

#kleptophagy #kleptoparasitism #heme

https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html

How #Staphylococcus aureus 'steals' #iron from our #blood during infections.

#kleptophagy #kleptoparasitism #heme

https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html

How #Staphylococcus aureus 'steals' #iron from our #blood during infections.

#kleptophagy #kleptoparasitism #heme

https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html

How #Staphylococcus aureus 'steals' #iron from our #blood during infections.

#kleptophagy #kleptoparasitism #heme

https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html

old but interesting research article [2017]:

Extracellular glycine is necessary for optimal hemoglobinization of erythroid cells
https://pmc.ncbi.nlm.nih.gov/articles/PMC5541866/

"Vertebrate heme synthesis requires three substrates: succinyl-CoA, which regenerates in the tricarboxylic acid cycle, iron and glycine. For each heme molecule synthesized, one atom of iron and eight molecules of glycine are needed."

#biology #biochemistry #heme #RBCs #glycine #anemia

@itsveganjim Years ago the WHO listed #meat as #carcinogenic.

https://nutritionsource.hsph.harvard.edu/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/

Note the bit about #heme iron for those claiming that they must eat meat to treat #anaemia. Get an iron infusion. I promise that, in the long run, that's a more cost-effective treatment for the #healthcare system and #ecosystem.

@itsveganjim Years ago the WHO listed #meat as #carcinogenic.

https://nutritionsource.hsph.harvard.edu/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/

Note the bit about #heme iron for those claiming that they must eat meat to treat #anaemia. Get an iron infusion. I promise that, in the long run, that's a more cost-effective treatment for the #healthcare system and #ecosystem.

@itsveganjim Years ago the WHO listed #meat as #carcinogenic.

https://nutritionsource.hsph.harvard.edu/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/

Note the bit about #heme iron for those claiming that they must eat meat to treat #anaemia. Get an iron infusion. I promise that, in the long run, that's a more cost-effective treatment for the #healthcare system and #ecosystem.

@itsveganjim Years ago the WHO listed #meat as #carcinogenic.

https://nutritionsource.hsph.harvard.edu/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/

Note the bit about #heme iron for those claiming that they must eat meat to treat #anaemia. Get an iron infusion. I promise that, in the long run, that's a more cost-effective treatment for the #healthcare system and #ecosystem.

@itsveganjim Years ago the WHO listed #meat as #carcinogenic.

https://nutritionsource.hsph.harvard.edu/2015/11/03/report-says-eating-processed-meat-is-carcinogenic-understanding-the-findings/

Note the bit about #heme iron for those claiming that they must eat meat to treat #anaemia. Get an iron infusion. I promise that, in the long run, that's a more cost-effective treatment for the #healthcare system and #ecosystem.

Hi @DNPFred
In grad school I worked on heme proteins using #paramagnetic #NMR and #NRVS. Then I shifted to #XRayCrystallography, using #EPR #UVVis and #EDX on #crystals when a postdoc. My research group works on #NonHemeIron #enzymes, & #heme, #copper & #manganese #metalloproteins. Really interested in combining #spectroscopy on #protein #crystals to examine #structure #function relationships.

Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.
New work from Abe et al shows that

"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."

#Chemotherapy #doxorubicin #mitochondria #heme

https://www.science.org/doi/10.1126/scisignal.abn8017?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial

Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.
New work from Abe et al shows that

"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."

#Chemotherapy #doxorubicin #mitochondria #heme

https://www.science.org/doi/10.1126/scisignal.abn8017?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial