#freephd — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #freephd, aggregated by home.social.
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Free PhD:
Give a mouse semaglutide, measure GLT-1 trafficking in corticostriatal astrocytes specifically, and show that the transporter redistribution is what causes the behavioral change
Materials:
(1) chronic semaglutide administration in a rodent model of compulsive behavior,
(2) single-particle tracking or FRAP to measure GLT-1 surface mobility and cluster dynamics specifically in corticostriatal astrocytes
(3) extracellular glutamate microdialysis in the same animals during behavioral challenge
(4) astrocyte-specific GLT-1 conditional knockdown as a control arm to show the behavioral rescue depends on transporter redistribution and not a parallel pathway.#freephd #astrocytesareagirlsbestfriend #neurostuffandthings #neuroscience #accordingtohoyle
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Free PhD:
Give a mouse semaglutide, measure GLT-1 trafficking in corticostriatal astrocytes specifically, and show that the transporter redistribution is what causes the behavioral change
Materials:
(1) chronic semaglutide administration in a rodent model of compulsive behavior,
(2) single-particle tracking or FRAP to measure GLT-1 surface mobility and cluster dynamics specifically in corticostriatal astrocytes
(3) extracellular glutamate microdialysis in the same animals during behavioral challenge
(4) astrocyte-specific GLT-1 conditional knockdown as a control arm to show the behavioral rescue depends on transporter redistribution and not a parallel pathway.#freephd #astrocytesareagirlsbestfriend #neurostuffandthings #neuroscience #accordingtohoyle
-
Free PhD:
Give a mouse semaglutide, measure GLT-1 trafficking in corticostriatal astrocytes specifically, and show that the transporter redistribution is what causes the behavioral change
Materials:
(1) chronic semaglutide administration in a rodent model of compulsive behavior,
(2) single-particle tracking or FRAP to measure GLT-1 surface mobility and cluster dynamics specifically in corticostriatal astrocytes
(3) extracellular glutamate microdialysis in the same animals during behavioral challenge
(4) astrocyte-specific GLT-1 conditional knockdown as a control arm to show the behavioral rescue depends on transporter redistribution and not a parallel pathway.#freephd #astrocytesareagirlsbestfriend #neurostuffandthings #neuroscience #accordingtohoyle
-
Free PhD:
Give a mouse semaglutide, measure GLT-1 trafficking in corticostriatal astrocytes specifically, and show that the transporter redistribution is what causes the behavioral change
Materials:
(1) chronic semaglutide administration in a rodent model of compulsive behavior,
(2) single-particle tracking or FRAP to measure GLT-1 surface mobility and cluster dynamics specifically in corticostriatal astrocytes
(3) extracellular glutamate microdialysis in the same animals during behavioral challenge
(4) astrocyte-specific GLT-1 conditional knockdown as a control arm to show the behavioral rescue depends on transporter redistribution and not a parallel pathway.#freephd #astrocytesareagirlsbestfriend #neurostuffandthings #neuroscience #accordingtohoyle
-
Free PhD:
Give a mouse semaglutide, measure GLT-1 trafficking in corticostriatal astrocytes specifically, and show that the transporter redistribution is what causes the behavioral change
Materials:
(1) chronic semaglutide administration in a rodent model of compulsive behavior,
(2) single-particle tracking or FRAP to measure GLT-1 surface mobility and cluster dynamics specifically in corticostriatal astrocytes
(3) extracellular glutamate microdialysis in the same animals during behavioral challenge
(4) astrocyte-specific GLT-1 conditional knockdown as a control arm to show the behavioral rescue depends on transporter redistribution and not a parallel pathway.#freephd #astrocytesareagirlsbestfriend #neurostuffandthings #neuroscience #accordingtohoyle
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"""
use known queueing math on a 3‑channel hex Jackson‑like network to calculate a symmetry‑breaking utilization, then identify that as the electroweak threshold and extract [m_H / v].
"""
--- you, upon having uttered your thesis aloud as you typed it into WordPerfect as reveal codes is still utterly indecipherable to AI===
Bet:
If you can take a hex, three‑channel, single‑server Jackson‑style network, derive a critical utilization and a “distance below criticality” parameter from known queueing theory, and that parameter comes out numerically comparable to [125/246], it’s a falsifiable quantitative link between a queueing threshold and the Higgs sector.
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"""
use known queueing math on a 3‑channel hex Jackson‑like network to calculate a symmetry‑breaking utilization, then identify that as the electroweak threshold and extract [m_H / v].
"""
--- you, upon having uttered your thesis aloud as you typed it into WordPerfect as reveal codes is still utterly indecipherable to AI===
Bet:
If you can take a hex, three‑channel, single‑server Jackson‑style network, derive a critical utilization and a “distance below criticality” parameter from known queueing theory, and that parameter comes out numerically comparable to [125/246], it’s a falsifiable quantitative link between a queueing threshold and the Higgs sector.
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Free PhD:
"""
Stimulant response in ADHD correlates better with perfusion change (ΔCBF) than
dopamine transporter occupancy (ΔDAT). (2) Ketamine response in depression correlates better with astrocytic/perfusion markers than glutamatergic markers. Both are immediately testable with existing methods.
"""[just needs someone to run the regression]
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Free PhD:
"""
Stimulant response in ADHD correlates better with perfusion change (ΔCBF) than
dopamine transporter occupancy (ΔDAT). (2) Ketamine response in depression correlates better with astrocytic/perfusion markers than glutamatergic markers. Both are immediately testable with existing methods.
"""[just needs someone to run the regression]
-
Free PhD:
"""
Stimulant response in ADHD correlates better with perfusion change (ΔCBF) than
dopamine transporter occupancy (ΔDAT).Ketamine response in depression correlates better with astrocytic/perfusion markers than glutamatergic markers.
Both are immediately testable with existing methods.
"""[just needs someone to run the regression]
-
Free PhD:
"""
Stimulant response in ADHD correlates better with perfusion change (ΔCBF) than
dopamine transporter occupancy (ΔDAT). (2) Ketamine response in depression correlates better with astrocytic/perfusion markers than glutamatergic markers. Both are immediately testable with existing methods.
"""[just needs someone to run the regression]
-
Free PhD:
"""
Stimulant response in ADHD correlates better with perfusion change (ΔCBF) than
dopamine transporter occupancy (ΔDAT).Ketamine response in depression correlates better with astrocytic/perfusion markers than glutamatergic markers.
Both are immediately testable with existing methods.
"""[just needs someone to run the regression]