#fluqe — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #fluqe, aggregated by home.social.
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Good Afternoon SARS2PAians!
I hope you are staying safe under this unusually hot weather. Please drink lots of water, pace yourself in the hottest hours of the day, and avoid caffeine! 🔥☀️🔥
If you must keep windows and doors closed during peak heat hours, run that Corsi-Rosenthal box to keep air clean.
Extremely hot weather precautions (closing doors and windows) are diametrically opposed to SARS2 control, much like midwinter heat retention and smoke prevention, but source control is still possible!
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VOCsNationally, KP.3.x.y and LB.x.y are the latest fastest variants. KP.2.3 is at the top, just barely, at almost 6% of national random sequencing, and KP.2 is already on the way out from the upcoming takover of KP.3 and LB.x variants.: https://ibb.co/fSZ7WRn
KP.3.1 is already in 3rd place and KP.3.3 already in fourth. KP.3.x and LB.x already, together, makes the largest proportion of random sequencing.
We are collectively too slow to react usefully to this virus as of now. National numbers are starting to go up from the sheer immune escape of these latest variants.
IN PA, lots of troublesome variants here already. KP.2.3 and KP.3.1 already tied for FIRST place here at 13% of random sequencing each. LB.1 and LB.1.7 right behind.: https://ibb.co/ccCmVbX
:coronavirus: :coronavirus: :coronavirus: Please consider masking up with a quality respirator in crowded places so these immune-escaping variants are kept at bay....ESPECIALLY during intense heat which makes keeping doors and windows open harder, and BEFORE JN.1/KP.3 vaccinations are available. :coronavirus: :coronavirus: :coronavirus:
In NY/NJ, LB.1.7 already at the top of the chart with a solid 10% of share. These new mutations are FAST due to immune escape. Practice source control to have a healthy Summer!: https://ibb.co/QNj7YJy
The latest CDC NOWCAST reflects all this...it shows KP.3 at a solid 33% of new infections. :coronavirus::coronavirus:Together with LB.1, these two are estimated to at least HALF of current infections.:coronavirus::coronavirus:: https://ibb.co/6RCStZs
We can see the impact of immune escape variants in other metrics, too.
Walgreens already has a majority of Eastern and Southern states at the highest change in positivity ratio from the previous week, and has for a while now.: https://ibb.co/XjDY2DP
In PA, Walgreens has a third of new tests showing positives. Testing is horribly low but the proportion is going up every week, and more tests will probably be done as people feel they need them done.: https://ibb.co/rvvB06B
CDC Early indicators show definite increases in test positivity and esecially ED visits, up 12.6% since last week!: https://ibb.co/0MzPY8q
CDC has ED visits growing nationally. This is due to immune escape of new variants. PA is showing moderate increases in ED visits due to SARS2 diagnoses. The overall level is still minimal, but new variants will keep bumping these numbers up of people ignore source control.: https://ibb.co/3mnzXgj
You can see the obvious advantage KP.3 has over older variants in this chart (the leftmost variant): https://ibb.co/BgjGkTr
Chart by virologist Benji Murrell.: https://ibb.co/vHj7RKQ
Sadly, we remain one of the States reporting the highest proportional deaths in a three-month period. 225 people have passed in the past 3 months from COVID.: https://ibb.co/G0phq72
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WastewaterWastewaterSCAN has national levels in SARS2 as HIGH in all regions.: https://ibb.co/jJSHb4V
In PA, lots of stations showing moderate increases in SARS2 material and increases are especially high in central Westmoreland Co. Pitt and Philly remain stable. No doubt this is due to newer immune-escaping variants.: https://ibb.co/qxfwg59
In our region, individual stations are showing medium and low levels individually but with a definite trend of many stations toward "high" levels.: https://ibb.co/tQFq4sZ
As immune-evasive mutations continue to permeate the State it's going to get increasingly important to perform some sort of source control. Mask up, stay home when sick, and run those Corsi-Rosenthal boxes if you need that A/C on!! 🔥☀️🔥
#COVID19 #COVID #COVIDisNotOver #SARS2PA
#Pennsylvania #PA
#FLuQE #Q493E #NOWCAST
#KP3 #LB1
#WearAMask #CleanTheAir #WashHands #VaccinesSaveLives #StayHomeIfSick ! -
Wochenlang stiegen die #COVID19 Zahlen laut dem österreichischen Abwassermonitoring langsam an, ohne eine richtige Welle zu werden. #FLiRT schaffte es nicht, wirklich abzuheben.
Jetzt kommt etwas mehr Dynamik ins Spiel. Zuletzt begannen die Zahlen mehr zu steigen. Dahinter steckt vor allem KP.3, ein weiterer Abkömmling von JN.1, Diese Variante weist eine weitere, #FLuQE genannte Mutation auf. KP.3 entkommt dem Immunsystem noch besser und bindet stärker an ACE2, die Eintrittspforte in die Zellen. Ein ungute Mischung.
Insgesamt sind die Zahlen aber noch niedrig, auch im Spital sehen wir noch nichts von einer Welle.
#COVID19at #kp3
Grafiken von abwassermonitoring.at und von zeitferne.github.io/covidat-tools/export/monitoring.html @zeitferne -
Good Muggy Morning SARS2PAians! ☁️💐☁️
I hope you are having a safe Spring!
The top news lately are the newest variants causing country-wide summer waves including Spain: https://ibb.co/hRpvjt5
and Portugal: https://ibb.co/khTtyJX
They are KP.3.x.y and LB.x.y.
These new immune evasive variants are filling up hospitals and causing notable increases in deaths.
KP.3 is now the variant "grandfather" that is the fastest, the most immune evasive, and the most easily bound to cells. Specifically, the most watched upcoming variant is its grandchild, KP.3.1.1.
The newest variants that have a very good chance of causing a sizeable increase in numbers, if not a full blown-out wave, are variants of KP.3 that already have immune evasive mutations (FLuQE) but also have an advantageous specific spike deletion (S:S31del).
These new and fastest variants are immune evasive to BOTH current vaccinations, AND prior infections.
Nationally, KP.2 is still just barely at the top of the leaderboard. KP.2.3 is right behind it, already a variant that is being watched.: https://ibb.co/p0d8G8n
🔴KP.3.1.1 is absolutely blazing fast and burning through Spain, Portugal and other countries, and is part of KP-DEL31.
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NOTE: "KP-DEL31" is gonna be my nickname for it, not variant hunters or virologists. Just to call it something easily condensed and recognizeable for now. They might decide on a different nickname soon. These names are just for convenience. (You don't call your cousin Mister James Robert Smith every time, do you? You call him JimBob or Smitty. It just makes talking easier.)
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I've highlighted FLiRT in pink on the national screenshot but I'll drop it soon as KP-DEL31 becomes more and more relevant.
There's no specific results for PA on the Tableau site. Probably not enough testing here.
In NY/NJ, I've highlighted KP-DEL31 in green on the NY/NJ leaderboard, and as you can see, all the top 5 variants there have this very important spike deletion. But KP.3.1.1 is the variant to keep eyes on.: https://ibb.co/Jcv0rF7
KP.3.1.1 is already found (in only a few days!) in TX, NY, CA, CO, NJ, WA, and VA.
🔴If you've dropped wearing respirators for now you might want to reconsider putting them back on as KP.3.1.1 makes gains and spring moves along.
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Wastewater has returned to HIGH levels in the Eastern and Southern states. KP.2, KP.3 and LB.x.y variants are working together on driving this.: https://ibb.co/0nHqQPS
In our region, specifically testing in Maryland is showing a return to higher levels.: https://ibb.co/99MSpy0
The PA wastewater dashboard is showing LARGE increases in Philly, and sizeable increases in Centre and Indiana counties.: https://ibb.co/0J14Tty
MASK UP, oh my Philly ❤️️!
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Whoa I had a whole angry thing typed out here and juuuuuuust checked back on Twitter, and Dr. Eric Topol wrote just 2 hrs ago that the US FDA has changed its decision for the upcoming vaccine base!!: https://ibb.co/xzB6GVb
The newest mRNA vaccines will be based on KP.2 and NOT JN.1!
This is a wise decision and fantastic news!!
This will certainly better prepare us for Summer.
(NOTE: **Novavax** will have a JN.1 based booster. Novavax is completely different as it has proven effective through multiple years with ONE base so that vaccine will probably not have to be changed as often.)
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🔴Even with vaccines, there are always other things we can do to practice source control!keep those windows OPEN
wear a respirator
keep the air clean
move meetings outside
work from home
build a Corsi-Rosenthal box
stay home if you are sick!
Continue to have a great and safe Spring!! 💐💐💐
#COVID19 #COVID #COVIDisNotOver #SARS2PA #Pennsylvania #PA
#FLiRT #F456L #R346T #spike_f456l #spike_r346t
#FLuQE #Q493E
#KP2 #KP3 #LB1 #Moderna #Pfizer #Novavax
#WearAMask #CleanTheAir #WashHands #VaccinesSaveLives #StayHomeIfSick ! -
update for 5/31/2024!!
Good Morning SARS2PAians!
I hope you are enjoying your Spring! 💐💐💐
I just have an update on VOCs as I have to run out the door, and also not much has changed in terms of numbers yet. I'm so sorry this is all I have time for right now.
Nationally, for VOCs, we have a lot of fast movers that might bump up numbers for the summer as they have elsewhere globally already. Looks like the fastest are going to be KP.3 and especially LB.1.: https://ibb.co/wzcJ05J
While we don't have any immensely increased numbers so far, nationally they are starting to slowly rise, and source control will be needed as these immune evasive and FAST variants catch on.
In PA, we have quite a few of the FLiRT variants (in pink) and upcoming immune evasive variants (in teal) coming up. Numbers for these new variants are low but might rise steadily as the spring goes on.: https://ibb.co/h1XS2hP
IN NY/NJ, LB.1 is already at the top of the chart 👀 and the speed of its rise is incredible considering how fast current variants are already!: https://ibb.co/dpRDrPd
Watching these new mutations will give a big clue on when to tighten up source control.
In the meantime, keep that air clean and just for future safety, keep a stock of N95s handy for H5N1 as it spreads through more and more domesticated animal species, the lastest which is alpacas. This is starting to make epidemiologists and viral geneticists kinda nervous.
Insist on full disclosure of animal health/testing/sequencing from farms. You might consider non-dairy milk, or maybe ultra-pasteurized milk. Another option is UHT, shelf-stable milk in sterile packaging (like Parmalat).
:coronavirus: DO NOT CONSUME RAW MILK OR UNDERCOOKED MEAT.:coronavirus:
Hope to have more time to do this on Moday (but not sure) so have a great weekend and be safe! 💐💐💐
#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #FLiRT #F456L #R346T #spike_f456l #spike_r346t
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Update for 5/24/2024!
Good morning SARS2PAians! (well, afternoon by the time I got all this ready)
I hope you are having a BEAUTIFUL and healthy day. 💐💐💐
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VOCsNationally, KP.2 is in the lead so far, easily displacng JN.1 variants.: https://ibb.co/JCWtxdr
KP.3 and LB.1 (DeFLiRT) are making FAST gains in the leaderboard, now up to around 5% each nationally.
They are still the top two successful variants that show great potential to take over from even KP.2.: https://ibb.co/kxHkfV1
🔴JN.1.50 is new, and was just designated on 5/18 and though genetically it's as fast as LB.1 and KP.3, it remains to be seen in meatspace how it will spread.
In PA, JN.1 still in the lead here in random sequencing at 20% and KP.2 behind it at 13%.: https://ibb.co/G7Nnft5
Unfortunately KP.3 has been found here. So we now have BOTH very fast DeFLiRT variants here for the summer, KP.3 and LB.1. Take care, keep windows open, clean the air, wear a quality respirator and be aware of social contacts. These two variants might push the numbers up this summer.
In NY/NJ, KP.2 in the lead and look at that LB.1....in second place at 10% of random testing already. Yikes. It's been making very fast gains for a while now there.: https://ibb.co/8xRfkkh
Some parts of Jersey have noticeable upticks of matarial concentraion on WastewaterSCAN.: https://ibb.co/7STgtLZ
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WastewaterTrying to get as much info as possible here since almsot everything useful is being discontinued. 🙄
SARS2 has been bumped up to MEDIUM nationally on WastewaterSCAN.: https://ibb.co/Wf5MdxN
There are noticeable upticks starting to happen in the Harrisburg and Chester areas.: https://ibb.co/g3HQZp0
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Non-SARS2 PathogensGastro pathogens Noro and Rotavirus are still in the HIGH category on WastewaterSCAN. Please wash hands carefully, wash fruits and veg, and be aware of kitchen cleanliness discipline to avoid cathing these bugs. Mostly because they're just gross 🤢
🔴Concerning H5N1 (HPAI, "bird flu"), we are NOT in flu season, so seeing upticks for Influenza A is extremely concerning.
This is what the FluA graphs SHOULD look like now in a normal post-FLuA season.: https://ibb.co/X4Q8szS
H5N1 is an influenza A. It's been upgraded to MEDIUM on WastewaterSCAN.: https://ibb.co/wKC300x
However, the online tool makes no differentiation between H5N1 and other types of FLuA. It also cannot tell live virus from inactivated virus or its fragments.
It's extremely telling, though, that the highest concentration of FluA is located exatly where herd breakouts have or are occuring, mostly in the middle of the country in the plains corridor.
To reduce the risk of contracting, transmlitting, or allowing H5N1/HPAI to mutate,
🔴🔴🔴DO NOT DRINK RAW MILK.🔴🔴🔴
I don't give a flying fart if it's legal to sell/buy here in PA. Do NOT be that guy. Do NOT encourage this pathogen to mutate and DO NOT endanger your own life or everyone else's by consuming raw or unpasteurized dairy products.
Use caution in handling raw dairy products, especially meat and milk. Pasteurization has been proven to kill FluA and fluA is very sensitive to heat, but please use caution, fully cook raw meat, and use good sanitary habits when working with raw farm products.
As always, some method of source control is always good to help keep these pathogens in check whether they're just annoying and gross OR have a high kill rate.
I hope you stay safe, enjoy the open windows in Spring, and ARE NOT DRINKING RAW MILK.
Have a great week!!
#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t
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Good morning SARS2PAians!
I hope your very cloudy annd humid Spring is going well. 💐💐💐
The only thing I have right now are VOC visuals.
Nationally, KP.2 in the lead at 12% of random sequencing. The FLiRT variants are not far behind and VERy fast variants KP.3 and LB.1 are still making fast gains even after only a few days.: https://ibb.co/309Ygcj
In PA, classic JN.1 is still at the lead here. We don't have KP.3 here but we do have fast mover LB.1 which is now over 5% of random sequencing.: https://ibb.co/CpyDWkH
IN NY/NJ, immune evasive variants LB.1 already at over 7% of testing and KP.3 almost at 5%.: https://ibb.co/LZ1hZM7
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WastewaterBiobot has released a statement saying they are stopping keeping up their COVID-19 wastwater visuals. There's still WastewaterSCAN but only three sheds are on there.: https://ibb.co/2tYPPcm
https://biobot.io/from-raw-data-to-actionable-insights-biobots-evolution-of-public-data-sharing/
This is another removal of a GREAT tool that helped everyone stay informed, and gave a heads-up when to buckle down on source control issues.
A very good potential replacement for Biobot is Iowa Covid-19 Tracker and I'll start to try to get familiar with that as soon as I can sit down to do it so the vizzes might look very different soon.: https://iowacovid19tracker.org/
I hope to have more info on Friday, and until then have a GREAT week and safe Spring! 💐💐💐
#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t
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Update for 5/17/2024!
Good morning SARS2PAians!
I hope you are staying healthy during this very cloudy and rainy period! 🌦🌧☁️☔️
VOCs
Nationally, the FLiRT group (in pink on the graph), which is the first group that can cause a rise in summer numbers in a few wweeks, is still pushing closer and closer to the top of the chart. FLiRT variant KP.2 is already at almost 10% nationally in random sequencing.: https://ibb.co/Wxtgg1N
The second group (KP.3, LB.1, JN.1.32) that can push up summer numbers is not far behind and is FAST.
To complicate issues even more:
It's been advised where I'm cruising around for this info that the second group is not only VERY immune-evasive to current variant antibodies, but also returning to a more lung-based symptom set rather a gut-based set. JN.1 is mainly centered in the gut, which makes wastewater monitoring more sensitive and more accurate.
A return to a more lung-based centered illness is a bad thing and will make wastewater testing not-as-sensitive as it was for JN.1 relatives.
In PA, KP.2 is already in the lead of random sequencing results at 16% of share.: https://ibb.co/6XpWGfF
We already have LB.1 here so it's oging to very important to track this fast moving and immune evasive variant.
In NY/NJ, KP.3 and LB.1 in fifth and sixth places on the leaderboard. Their rise is increasing quickly as they're up to over 4% of varaint share, up from 3% a week ago.: https://ibb.co/9gsdZ0W
A 1% increase in such a short amount of time in a field of already very fast variants is noteworthy. In a race of thoroughbreds, varaints like this are the potential triple-crown winners.
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WastewaterWastewater levels are still very good (low.) Nationally we're at the same level as last year but not low enough to match 2021 yet.: https://ibb.co/Y3Tv51h
In PA, not much to say. EVERYONE is smashing it. Bucks county area a bit higher than naitonal levels and trending upwards. PLEase use precaution and some sort of source control so these numbers don't go back up.: https://ibb.co/hd2FcNh
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That's all I have this morning, so I hope you have a GREAT week! I apologize for not updating consistently as data is harder to obtain and H5N1 takes over the foreground of virology conversations (as it should, understandable)!!
#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t
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Update for 5/13/2024!
Good Morning SARS2PAians!
I hope your chilly Spring is going well! 💐💐💐
Just a very quick VOC update as there is absolutely nothing really updated to work with this week 🙄
While numbers are still very very low right now (which is great), the virology world and variant hunters are watching a few new mutations lately.
The two most important coming up are KP.3 and LB.1.
Globally, KP.3 is already in 2nd place, very high in places like the UK and Australia, easily growing past previous JN.1 incarnations AND FLiRT variants.: https://ibb.co/ch19ph8
It carries a very rare mutation (S:Q493E) that enhances its fitness and will enable it to grow much fater than previous JN.1 incarnations.: https://ibb.co/9vx0JTn
It is IMMUNE EVASIVE compared to all current acquired immunity, both by vaccination and infection. It's fast enough and evasive enough to probably bump up numbers in June or July.
In the US, KP.3 is in relatively low numbers right now: https://ibb.co/XpRF6D6
BUT KP.3 is growing very quickly as the previous variant snapshot show when put together:
4/01-- 0.34%
4/05-- 0.44%
4/12-- 0.63%
4/19-- 1.17%
4/25-- 1.55%
5/03-- 1.64%
5/06-- 2.23%
5/12-- 3.20%
(This is fast in a landscape that's already thoroughly saturated very very vast variants.)
In PA, variant sequencers have not seen KP.3 pop up yet (doesn't mean it's not here, sequencing and testing are soooooo loooow but at least it's not showing up on the leaderboard.): https://ibb.co/4YzwNFN
However, LB.1 (from the FLiRT group but with an important deletion {S:531del}) is another very fast variant that is probably enough to bump up numbers too.
The summer will probably be FLiRT + FLiRT children vs. KP.3 (nicknamed FLuQE) + FLuQE children.
Those two mutation classes together wil probably start pushing up numbers again in early June.
Unfortunately that's all I have for now as it's getting harder and harder to find updated info.
I hope your Spring continues to be healthy! 💐💐💐
#covid #Covid19 #SARS2PA #CovidIsNotOver #Pennsylvania #PA #JN1 #FLiRT #F456L #R346T #spike_f456l #spike_r346t