#zikavirus — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #zikavirus, aggregated by home.social.
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Harris County's health department has launched a new online dashboard to track human cases of mosquito-borne illnesses.
#HarrisCounty #HealthScience #Local #News #CityOfHouston #HarrisCountyPublicHealth #Mosquitos #WestNileVirus #ZikaVirus
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A Rare Win for Vitamin D — This Time in MS https://www.diningandcooking.com/1946757/a-rare-win-for-vitamin-d-this-time-in-ms/ #AlzheimerDisease #Alzheimer'sDisease #connecticut #fellows #Fellowship #KidneyFailure #KidneyInsufficiency #MultipleSclerosis;MultipleSclerosis(MS) #nutrition #RenalFailure #RenalImpairment #RenalInsufficiency #residency #Residents #TropicalDisease #TropicalInfection #VisionCareAndMaintenance #VitaminDDeficiency #Vitamins #zika #ZikaDisease #ZikaFever #ZikaVirus #ZIKV
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Protective threshold of a potent neutralizing #Zika virus monoclonal #antibody in rhesus #macaques
Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.01429-24?af=R
ABSTRACT
Zika virus (ZIKV) is a mosquito-borne flavivirus that caused a global pandemic in 2016–2017 with continued ongoing transmission at low levels in several countries. In the absence of an approved ZIKV vaccine, neutralizing monoclonal antibodies (mAbs) provide an option for the prevention and treatment of ZIKV infection. Previous studies identified a potent neutralizing human mAb ZIKV-117 that reduced fetal infection and death in mice following ZIKV challenge. In this study, we report exquisite potency of ZIKV-117-LALA-YTE, which has been engineered to reduce Fc receptor binding and to extend half-life, in a titration study in rhesus macaques to protect against ZIKV challenge. We show complete protection at a dose of 0.016 mg/kg ZIKV-117-LALA-YTE, which resulted in median serum concentrations of 0.13 µg/mL. The high potency of this mAb supports its potential clinical development as a novel biotherapeutic intervention for ZIKV.____
#abstract #animalModels #monoclonalAntibodies #research #zikaVirus
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New Zika virus lineages show increased fitness
#ZikaVirus
#Zika
#PLOS
#NeglectedTropicalDiseases
#PhenitypicAdaptation
#Mosquito
#Mosquitos
#Mozzies
#Clades
#Mutations
#ZikaEpidemic https://www.news-medical.net/news/20230209/New-Zika-virus-lineages-show-increased-fitness.aspx
>The current study, published in the journal PLOS Neglected Tropical Diseases, aimed to explore the possible phenotypic adaptation of the Zika virus to increase its transmissibility and virulence in the Americas.