#winny — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #winny, aggregated by home.social.
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https://www.wacoca.com/media/623489/ 三浦貴大が『風、薫る』に与えるアクセント 『国宝』に通じる“現実を突きつける”存在に？ – Real Sound｜リアルサウンド #television #tv #TVPrograms #Winny #テレビ #テレビ番組 #やがて海になる #三浦貴大 #国宝 #折田侑駿 #風、薫る #風、薫るコラム
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アーカイブの危機とメンテナンスの大事さ
2025.01.15
https://wirelesswire.jp/2025/01/87960/津田大介氏の文章
＞ 今、00年代の情報を検索するのは難しい。たくさんあった無料のホームページサービスも、たいていなくなった。グーグルの検索も年々使い物にならなくなっている。かつては紙の本は絶版になると接しにくくなり、インターネットは情報が消えないと思われていたのが、今はネットの古い情報の方がアクセスしづらくなっています。
＞ みそもくそも一緒になった巨大な知のデータベースだったインターネットが、リアルタイムウェブに駆逐されたことによって、アーカイブ機能がどんどん弱くなり、その結果、リアルタイムで発信される扇情的で、真偽不確かな情報の流通プラットフォームになってしまった。
#geocities はなくなっちゃったし、#youtube もどんどん消えちゃうからブックマークしてたってあまり意味がない。
本当に重要なものはコピペしてなんとか自分がローカルに保存しなくちゃならない。多分他の人もそうやってる人多いと思うので、そういう人同士で過去のウェブ情報を共有する仕組みがあったらいいな、と思うとそれは #winny になってしまったりするから厄介だ。
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The thyroid cancer result is pretty much a gimme, but what is going on with breast, lung & glioma? Misclassified metastatic thyroid cancer or some type of ectopic translation in primary tumors?
Thyroglobulin―HPA mRNA cancer type distributions (#TG:r) with GPMDB cancer type tabbulations (#TG:p). #proteomics #winny
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Winnowed out of the CPTAC lung adenocarcinoma (LUAD) study.
Secretoglobin family 3A member 2―HPA mRNA cancer type distributions (#SCGB3A2:r) with GPMDB cancer type tabbulations (#SCGB3A2:p). #proteomics #winny
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Hepatocytes have a lot of metabolic roles unto themselves, making it fairly easy to distinguish hepatoma from metastatic lesions originating from other cell types using the concentrations of specific proteins as diagnostic markers.
#CYP3A4:p (cytochrome P450 3A4), #HSD17B13:p (hydroxysteroid 17-β dehydrogenase 13), #UGT2B10:p (UDP glucuronosyltransferase 2B10), #UPB1:p (β-ureidopropionase 1): HPA mRNA cancer type distributions with GPMDB tissue & cancer type tabbulations. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
This gene, also known as mammaglobin-1, shows significant protein & mRNA enrichment in invasive ductal carcinoma. Describe three practical analytical methods of using this observation to create a clinical test to positively identify breast cancer metastatic lesions.
#SCGB2A2:p (secretoglobin family 2A member 2): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny (12/12, fin)
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From the final exam for "Biomarkers: fact & fiction".
This rarely observed, apoptosis-related protein is over-represented in breast cancer tissue. Discuss the pros and cons of using a protein involved in a cell death process as a diagnostic marker in clinical test.
#PYDC1:p (pyrin domain containing 1 ): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
This cell surface peptide hormome receptor has a well-understood function in normal breast tissue & its dysfunction is involved in tumour proliferation. List & discuss three cytokine-associated transcription pathways that can be affected by the prolactin/PRLR:p complex.
#PRLR:p (prolactin receptor): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
This protein converts norepinephrine (noradrenaline) to epinephrine (adrenaline) and is found to be elevated in some breast cancers. Discuss how you would validate using this protein as part of a multi-protein prognostic signature for clinically relevant tumour types.
#PNMT:p (phenylethanolamine N-methyltransferase): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
The mRNA & protein associated with this gene are both elevated in breast cancer. Use this protein as an example of how to utilize absolute protein levels in tumours both for the purposes of sub-typing the disease and guiding treatment.
#PGR:p (progesterone receptor): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
The mRNA & protein associated with this gene are both elevated in breast cancer. Discuss the pro & cons of using either (or both) of these molecules in clinical diagnosis. What types of lab tests would be required for each modality & how you would go about determining diagnostic interpretations for the results?
#MUCL1:p (mucin like 1): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
This protein is elevated in invasive ductal carcinoma, compared to other cancers. Discuss research on using ESR1:p & its sequence features to clinically classify breast cancer tumours and its use in selecting treatment option.
#ESR1:p (estrogen receptor 1): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
This protein has potential as an indicator of two tissue specific adenocarcinomas. What additional clinical information would be necessary to distinguish between these alternatives given a positive test for the protein?
#GRPR:p (gastrin releasing peptide receptor): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
This protein has potential as an indicator of a tissue specific adenocarcinoma. Discuss the case for and against using of an intracellular metabolic enzyme for this purpose.
#GLYATL2:p (glycine-N-acyltransferase like 2): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulation. #proteomics #winny
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From the final exam for "Biomarkers: fact & fiction".
This protein has potential as an indicator of breast cancer. Describe how you would go about determining if it is best suited to be a marker for primary (at the site of origination) or secondary (metastatic, disseminated) tumour tissue.
#CLEC3A:p (C-type lectin domain family 3 member A): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulations. #proteomics #winny
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#Winny, the #Proteomics Ontology & Oncology Predictor.
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From the final exam for "Biomarkers: fact & fiction".
This protein has potential as an indicator of breast cancer. Describe how you would go about verifying its clinical utility. Be sure to include estimated duration & cost of the necessary studies.
#GFRA1:p (glial cell line-derived neurotrophic factor family receptor alpha 1): Human Protein Atlas mRNA cancer type distribution and GPMDB cancer type tabbulations. #proteomics #winny
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It is just shooting fish in a barrel, now. #proteomics #winny
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It seems to work. An eigenvalue here, an eigenvalue there, some stats, some nice data, a lot of information & bingo-bango-boom, there they are.
#OCA2:p (OCA2 melanosomal transmembrane protein), #BIRC7:p (baculoviral IAP repeat containing 7), #MLANA:p (melan-A), #DCT:p (dopachrome tautomerase): Human Protein Atlas mRNA cancer type distribution and GPMDB protein tissue & cancer type tabbulations. #proteomics #winny
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This one is a membrane protein with 11 TMs, normally found at low levels in melanocytes but more prominent in melanoma.
#SLC24A5 (solute carrier family 24 member 5): Human Protein Atlas mRNA cancer type distribution and GPMDB protein tissue & cancer type tabbulations. #proteomics #winny
