#ukcilia2024 — Public Fediverse posts

Then the high point of #ukcilia2024 e-symposia our breakout panel discussions- talk of #cilia synapses, 'not all cilia have equal opportunity for signaling' and connections and how they evolve, and more... 7/8

We close with Dan Dodd (Mill lab, MRC HGU) on unique #cilia & #centriole-specific functions for #tubulin isotype TUBB4B with dominant negative roles in motile & non-motile #ciliopathies. New insights from Alan Brown & Jeff Ti Labs. Deep read: www.medrxiv.org/content/10.1... #ukcilia2024 6/8

#Mouse genetics reveal different neuron-specific #cilia functions to different #drugs via GPCRs to drive motivated behaviours Jeremy McIntyre (U Florida). Deep read: https://journals.sagepub.com/doi/10.1177/02698811231219058 #ukcilia2024 5/8

Part II Saikat Mukhopadhyay (UTSW) on mechanism of #cilia disassembly as cells migrate during differentiation- partial loss of cilia maintenance gene expression programme in cerebellar granular neurons- no PCM, no satellites but centrioles intact! https://www.biorxiv.org/content/10.1101/2023.12.07.565993v1 #ukcilia2024 4/8

Then a double billing of curious roles for #cilia disassembly in cerebellar granular neuron differentiation using #volumetricEM to map changes in structure- tour-de-force talk by Carolyn Ott (JLS lab, HHMI Janelia). Must read pre-print 1: https://www.biorxiv.org/content/10.1101/2023.12.07.565988v1 #ukcilia2024 3/8

On to beta islet cell #cilia in stunning FIB-SEM vEM from human & mouse pancreas. Masterclass talk by Andreas Müller (Solimena lab, TU Dresden) with Nikolai Klena Gaia Pigino with incredible cellular connections & signal exposure! https://www.biorxiv.org/content/10.1101/2023.12.01.568979v4 #ukcilia2024 2/8